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Macular Thickness Decrease in Asymptomatic Subjects at High Genetic Risk of Developing Alzheimer’s Disease: An OCT Study

In this case control study, we examined the retinal thickness of the different layers in the macular region and peripapillary retinal nerve fiber layer (RNFL) with optical coherence tomography (OCT) in healthy cognitive subjects (from 51 to 74 years old) at high genetic risk for developing Alzheimer...

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Autores principales: López-Cuenca, Inés, de Hoz, Rosa, Salobrar-García, Elena, Elvira-Hurtado, Lorena, Rojas, Pilar, Fernández-Albarral, José A., Barabash, Ana, Salazar, Juan J., Ramírez, Ana I., Ramírez, José M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355697/
https://www.ncbi.nlm.nih.gov/pubmed/32503282
http://dx.doi.org/10.3390/jcm9061728
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author López-Cuenca, Inés
de Hoz, Rosa
Salobrar-García, Elena
Elvira-Hurtado, Lorena
Rojas, Pilar
Fernández-Albarral, José A.
Barabash, Ana
Salazar, Juan J.
Ramírez, Ana I.
Ramírez, José M.
author_facet López-Cuenca, Inés
de Hoz, Rosa
Salobrar-García, Elena
Elvira-Hurtado, Lorena
Rojas, Pilar
Fernández-Albarral, José A.
Barabash, Ana
Salazar, Juan J.
Ramírez, Ana I.
Ramírez, José M.
author_sort López-Cuenca, Inés
collection PubMed
description In this case control study, we examined the retinal thickness of the different layers in the macular region and peripapillary retinal nerve fiber layer (RNFL) with optical coherence tomography (OCT) in healthy cognitive subjects (from 51 to 74 years old) at high genetic risk for developing Alzheimer’s disease (AD). Thirty-five subjects with a family history of Alzheimer disease (AD) (FH+) and ApoE ɛ4 carriers and 29 age-matched control subjects without a family history of AD (FH−) and ApoE ɛ4 non-carriers were included. Compared to FH− ApoE ɛ4 non-carriers, in FH+ ApoE ɛ4 carriers, there were statistically significant decreases (p < 0.05) in (i) the foveal area of mRNFL; (ii) the inferior and nasal sectors in the outer and inner macular ring in the inner plexiform layer (IPL); (iii) the foveal area and the inferior sector in the outer macular ring in the inner nuclear layer (INL); and (iv) the inferior sector of the outer macular ring in the outer plexiform layer (OPL). However, no statistically significant differences were found in the peripapillary thickness of RNFL between both study groups. In subjects with cognitive health and high genetic risk for the development of AD, initial changes appeared in the macular area. OCT could be a promising, cost-effective and non-invasive test useful in early AD, before the onset of clinical symptoms.
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spelling pubmed-73556972020-07-23 Macular Thickness Decrease in Asymptomatic Subjects at High Genetic Risk of Developing Alzheimer’s Disease: An OCT Study López-Cuenca, Inés de Hoz, Rosa Salobrar-García, Elena Elvira-Hurtado, Lorena Rojas, Pilar Fernández-Albarral, José A. Barabash, Ana Salazar, Juan J. Ramírez, Ana I. Ramírez, José M. J Clin Med Article In this case control study, we examined the retinal thickness of the different layers in the macular region and peripapillary retinal nerve fiber layer (RNFL) with optical coherence tomography (OCT) in healthy cognitive subjects (from 51 to 74 years old) at high genetic risk for developing Alzheimer’s disease (AD). Thirty-five subjects with a family history of Alzheimer disease (AD) (FH+) and ApoE ɛ4 carriers and 29 age-matched control subjects without a family history of AD (FH−) and ApoE ɛ4 non-carriers were included. Compared to FH− ApoE ɛ4 non-carriers, in FH+ ApoE ɛ4 carriers, there were statistically significant decreases (p < 0.05) in (i) the foveal area of mRNFL; (ii) the inferior and nasal sectors in the outer and inner macular ring in the inner plexiform layer (IPL); (iii) the foveal area and the inferior sector in the outer macular ring in the inner nuclear layer (INL); and (iv) the inferior sector of the outer macular ring in the outer plexiform layer (OPL). However, no statistically significant differences were found in the peripapillary thickness of RNFL between both study groups. In subjects with cognitive health and high genetic risk for the development of AD, initial changes appeared in the macular area. OCT could be a promising, cost-effective and non-invasive test useful in early AD, before the onset of clinical symptoms. MDPI 2020-06-03 /pmc/articles/PMC7355697/ /pubmed/32503282 http://dx.doi.org/10.3390/jcm9061728 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
López-Cuenca, Inés
de Hoz, Rosa
Salobrar-García, Elena
Elvira-Hurtado, Lorena
Rojas, Pilar
Fernández-Albarral, José A.
Barabash, Ana
Salazar, Juan J.
Ramírez, Ana I.
Ramírez, José M.
Macular Thickness Decrease in Asymptomatic Subjects at High Genetic Risk of Developing Alzheimer’s Disease: An OCT Study
title Macular Thickness Decrease in Asymptomatic Subjects at High Genetic Risk of Developing Alzheimer’s Disease: An OCT Study
title_full Macular Thickness Decrease in Asymptomatic Subjects at High Genetic Risk of Developing Alzheimer’s Disease: An OCT Study
title_fullStr Macular Thickness Decrease in Asymptomatic Subjects at High Genetic Risk of Developing Alzheimer’s Disease: An OCT Study
title_full_unstemmed Macular Thickness Decrease in Asymptomatic Subjects at High Genetic Risk of Developing Alzheimer’s Disease: An OCT Study
title_short Macular Thickness Decrease in Asymptomatic Subjects at High Genetic Risk of Developing Alzheimer’s Disease: An OCT Study
title_sort macular thickness decrease in asymptomatic subjects at high genetic risk of developing alzheimer’s disease: an oct study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355697/
https://www.ncbi.nlm.nih.gov/pubmed/32503282
http://dx.doi.org/10.3390/jcm9061728
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