Cargando…
Macular Thickness Decrease in Asymptomatic Subjects at High Genetic Risk of Developing Alzheimer’s Disease: An OCT Study
In this case control study, we examined the retinal thickness of the different layers in the macular region and peripapillary retinal nerve fiber layer (RNFL) with optical coherence tomography (OCT) in healthy cognitive subjects (from 51 to 74 years old) at high genetic risk for developing Alzheimer...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355697/ https://www.ncbi.nlm.nih.gov/pubmed/32503282 http://dx.doi.org/10.3390/jcm9061728 |
_version_ | 1783558336508067840 |
---|---|
author | López-Cuenca, Inés de Hoz, Rosa Salobrar-García, Elena Elvira-Hurtado, Lorena Rojas, Pilar Fernández-Albarral, José A. Barabash, Ana Salazar, Juan J. Ramírez, Ana I. Ramírez, José M. |
author_facet | López-Cuenca, Inés de Hoz, Rosa Salobrar-García, Elena Elvira-Hurtado, Lorena Rojas, Pilar Fernández-Albarral, José A. Barabash, Ana Salazar, Juan J. Ramírez, Ana I. Ramírez, José M. |
author_sort | López-Cuenca, Inés |
collection | PubMed |
description | In this case control study, we examined the retinal thickness of the different layers in the macular region and peripapillary retinal nerve fiber layer (RNFL) with optical coherence tomography (OCT) in healthy cognitive subjects (from 51 to 74 years old) at high genetic risk for developing Alzheimer’s disease (AD). Thirty-five subjects with a family history of Alzheimer disease (AD) (FH+) and ApoE ɛ4 carriers and 29 age-matched control subjects without a family history of AD (FH−) and ApoE ɛ4 non-carriers were included. Compared to FH− ApoE ɛ4 non-carriers, in FH+ ApoE ɛ4 carriers, there were statistically significant decreases (p < 0.05) in (i) the foveal area of mRNFL; (ii) the inferior and nasal sectors in the outer and inner macular ring in the inner plexiform layer (IPL); (iii) the foveal area and the inferior sector in the outer macular ring in the inner nuclear layer (INL); and (iv) the inferior sector of the outer macular ring in the outer plexiform layer (OPL). However, no statistically significant differences were found in the peripapillary thickness of RNFL between both study groups. In subjects with cognitive health and high genetic risk for the development of AD, initial changes appeared in the macular area. OCT could be a promising, cost-effective and non-invasive test useful in early AD, before the onset of clinical symptoms. |
format | Online Article Text |
id | pubmed-7355697 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-73556972020-07-23 Macular Thickness Decrease in Asymptomatic Subjects at High Genetic Risk of Developing Alzheimer’s Disease: An OCT Study López-Cuenca, Inés de Hoz, Rosa Salobrar-García, Elena Elvira-Hurtado, Lorena Rojas, Pilar Fernández-Albarral, José A. Barabash, Ana Salazar, Juan J. Ramírez, Ana I. Ramírez, José M. J Clin Med Article In this case control study, we examined the retinal thickness of the different layers in the macular region and peripapillary retinal nerve fiber layer (RNFL) with optical coherence tomography (OCT) in healthy cognitive subjects (from 51 to 74 years old) at high genetic risk for developing Alzheimer’s disease (AD). Thirty-five subjects with a family history of Alzheimer disease (AD) (FH+) and ApoE ɛ4 carriers and 29 age-matched control subjects without a family history of AD (FH−) and ApoE ɛ4 non-carriers were included. Compared to FH− ApoE ɛ4 non-carriers, in FH+ ApoE ɛ4 carriers, there were statistically significant decreases (p < 0.05) in (i) the foveal area of mRNFL; (ii) the inferior and nasal sectors in the outer and inner macular ring in the inner plexiform layer (IPL); (iii) the foveal area and the inferior sector in the outer macular ring in the inner nuclear layer (INL); and (iv) the inferior sector of the outer macular ring in the outer plexiform layer (OPL). However, no statistically significant differences were found in the peripapillary thickness of RNFL between both study groups. In subjects with cognitive health and high genetic risk for the development of AD, initial changes appeared in the macular area. OCT could be a promising, cost-effective and non-invasive test useful in early AD, before the onset of clinical symptoms. MDPI 2020-06-03 /pmc/articles/PMC7355697/ /pubmed/32503282 http://dx.doi.org/10.3390/jcm9061728 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article López-Cuenca, Inés de Hoz, Rosa Salobrar-García, Elena Elvira-Hurtado, Lorena Rojas, Pilar Fernández-Albarral, José A. Barabash, Ana Salazar, Juan J. Ramírez, Ana I. Ramírez, José M. Macular Thickness Decrease in Asymptomatic Subjects at High Genetic Risk of Developing Alzheimer’s Disease: An OCT Study |
title | Macular Thickness Decrease in Asymptomatic Subjects at High Genetic Risk of Developing Alzheimer’s Disease: An OCT Study |
title_full | Macular Thickness Decrease in Asymptomatic Subjects at High Genetic Risk of Developing Alzheimer’s Disease: An OCT Study |
title_fullStr | Macular Thickness Decrease in Asymptomatic Subjects at High Genetic Risk of Developing Alzheimer’s Disease: An OCT Study |
title_full_unstemmed | Macular Thickness Decrease in Asymptomatic Subjects at High Genetic Risk of Developing Alzheimer’s Disease: An OCT Study |
title_short | Macular Thickness Decrease in Asymptomatic Subjects at High Genetic Risk of Developing Alzheimer’s Disease: An OCT Study |
title_sort | macular thickness decrease in asymptomatic subjects at high genetic risk of developing alzheimer’s disease: an oct study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355697/ https://www.ncbi.nlm.nih.gov/pubmed/32503282 http://dx.doi.org/10.3390/jcm9061728 |
work_keys_str_mv | AT lopezcuencaines macularthicknessdecreaseinasymptomaticsubjectsathighgeneticriskofdevelopingalzheimersdiseaseanoctstudy AT dehozrosa macularthicknessdecreaseinasymptomaticsubjectsathighgeneticriskofdevelopingalzheimersdiseaseanoctstudy AT salobrargarciaelena macularthicknessdecreaseinasymptomaticsubjectsathighgeneticriskofdevelopingalzheimersdiseaseanoctstudy AT elvirahurtadolorena macularthicknessdecreaseinasymptomaticsubjectsathighgeneticriskofdevelopingalzheimersdiseaseanoctstudy AT rojaspilar macularthicknessdecreaseinasymptomaticsubjectsathighgeneticriskofdevelopingalzheimersdiseaseanoctstudy AT fernandezalbarraljosea macularthicknessdecreaseinasymptomaticsubjectsathighgeneticriskofdevelopingalzheimersdiseaseanoctstudy AT barabashana macularthicknessdecreaseinasymptomaticsubjectsathighgeneticriskofdevelopingalzheimersdiseaseanoctstudy AT salazarjuanj macularthicknessdecreaseinasymptomaticsubjectsathighgeneticriskofdevelopingalzheimersdiseaseanoctstudy AT ramirezanai macularthicknessdecreaseinasymptomaticsubjectsathighgeneticriskofdevelopingalzheimersdiseaseanoctstudy AT ramirezjosem macularthicknessdecreaseinasymptomaticsubjectsathighgeneticriskofdevelopingalzheimersdiseaseanoctstudy |