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Combination Therapy and Nanoparticulate Systems: Smart Approaches for the Effective Treatment of Breast Cancer
Breast cancer has become one of the biggest concerns for oncologists in the past few decades because of its unpredictable etiopathology and nonavailability of personalized translational medicine. The number of women getting affected by breast cancer has increased dramatically, owing to lifestyle and...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355786/ https://www.ncbi.nlm.nih.gov/pubmed/32521684 http://dx.doi.org/10.3390/pharmaceutics12060524 |
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author | Gadag, Shivaprasad Sinha, Shristi Nayak, Yogendra Garg, Sanjay Nayak, Usha Y. |
author_facet | Gadag, Shivaprasad Sinha, Shristi Nayak, Yogendra Garg, Sanjay Nayak, Usha Y. |
author_sort | Gadag, Shivaprasad |
collection | PubMed |
description | Breast cancer has become one of the biggest concerns for oncologists in the past few decades because of its unpredictable etiopathology and nonavailability of personalized translational medicine. The number of women getting affected by breast cancer has increased dramatically, owing to lifestyle and environmental changes. Besides, the development of multidrug resistance has become a challenge in the therapeutic management of breast cancer. Studies reveal that the use of monotherapy is not effective in the management of breast cancer due to high toxicity and the development of resistance. Combination therapies, such as radiation therapy with adjuvant therapy, endocrine therapy with chemotherapy, and targeted therapy with immunotherapy, are found to be effective. Thus, multimodal and combination treatments, along with nanomedicine, have emerged as a promising strategy with minimum side effects and drug resistance. In this review, we emphasize the multimodal approaches and recent advancements in breast cancer treatment modalities, giving importance to the current data on clinical trials. The novel treatment approach by targeted therapy, according to type, such as luminal, HER2 positive, and triple-negative breast cancer, are discussed. Further, passive and active targeting technologies, including nanoparticles, bioconjugate systems, stimuli-responsive, and nucleic acid delivery systems, including siRNA and aptamer, are explained. The recent research exploring the role of nanomedicine in combination therapy and the possible use of artificial intelligence in breast cancer therapy is also discussed herein. The complexity and dynamism of disease changes require the constant upgrading of knowledge, and innovation is essential for future drug development for treating breast cancer. |
format | Online Article Text |
id | pubmed-7355786 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-73557862020-07-23 Combination Therapy and Nanoparticulate Systems: Smart Approaches for the Effective Treatment of Breast Cancer Gadag, Shivaprasad Sinha, Shristi Nayak, Yogendra Garg, Sanjay Nayak, Usha Y. Pharmaceutics Review Breast cancer has become one of the biggest concerns for oncologists in the past few decades because of its unpredictable etiopathology and nonavailability of personalized translational medicine. The number of women getting affected by breast cancer has increased dramatically, owing to lifestyle and environmental changes. Besides, the development of multidrug resistance has become a challenge in the therapeutic management of breast cancer. Studies reveal that the use of monotherapy is not effective in the management of breast cancer due to high toxicity and the development of resistance. Combination therapies, such as radiation therapy with adjuvant therapy, endocrine therapy with chemotherapy, and targeted therapy with immunotherapy, are found to be effective. Thus, multimodal and combination treatments, along with nanomedicine, have emerged as a promising strategy with minimum side effects and drug resistance. In this review, we emphasize the multimodal approaches and recent advancements in breast cancer treatment modalities, giving importance to the current data on clinical trials. The novel treatment approach by targeted therapy, according to type, such as luminal, HER2 positive, and triple-negative breast cancer, are discussed. Further, passive and active targeting technologies, including nanoparticles, bioconjugate systems, stimuli-responsive, and nucleic acid delivery systems, including siRNA and aptamer, are explained. The recent research exploring the role of nanomedicine in combination therapy and the possible use of artificial intelligence in breast cancer therapy is also discussed herein. The complexity and dynamism of disease changes require the constant upgrading of knowledge, and innovation is essential for future drug development for treating breast cancer. MDPI 2020-06-08 /pmc/articles/PMC7355786/ /pubmed/32521684 http://dx.doi.org/10.3390/pharmaceutics12060524 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Gadag, Shivaprasad Sinha, Shristi Nayak, Yogendra Garg, Sanjay Nayak, Usha Y. Combination Therapy and Nanoparticulate Systems: Smart Approaches for the Effective Treatment of Breast Cancer |
title | Combination Therapy and Nanoparticulate Systems: Smart Approaches for the Effective Treatment of Breast Cancer |
title_full | Combination Therapy and Nanoparticulate Systems: Smart Approaches for the Effective Treatment of Breast Cancer |
title_fullStr | Combination Therapy and Nanoparticulate Systems: Smart Approaches for the Effective Treatment of Breast Cancer |
title_full_unstemmed | Combination Therapy and Nanoparticulate Systems: Smart Approaches for the Effective Treatment of Breast Cancer |
title_short | Combination Therapy and Nanoparticulate Systems: Smart Approaches for the Effective Treatment of Breast Cancer |
title_sort | combination therapy and nanoparticulate systems: smart approaches for the effective treatment of breast cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355786/ https://www.ncbi.nlm.nih.gov/pubmed/32521684 http://dx.doi.org/10.3390/pharmaceutics12060524 |
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