Cargando…

The potential health benefits of dietary natural plant products in age related eye diseases

In the past decade, there has been a tremendous increase in the number of cases of age-related eye diseases such as age-related macular degeneration (AMD), cataract, diabetic retinopathy and glaucoma. These diseases are the leading causes of visual impairment and blindness all over the world and are...

Descripción completa

Detalles Bibliográficos
Autores principales: Ikonne, Eleazar Uchenna, Ikpeazu, Victor Okezie, Ugbogu, Eziuche Amadike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355812/
https://www.ncbi.nlm.nih.gov/pubmed/32685729
http://dx.doi.org/10.1016/j.heliyon.2020.e04408
_version_ 1783558362320863232
author Ikonne, Eleazar Uchenna
Ikpeazu, Victor Okezie
Ugbogu, Eziuche Amadike
author_facet Ikonne, Eleazar Uchenna
Ikpeazu, Victor Okezie
Ugbogu, Eziuche Amadike
author_sort Ikonne, Eleazar Uchenna
collection PubMed
description In the past decade, there has been a tremendous increase in the number of cases of age-related eye diseases such as age-related macular degeneration (AMD), cataract, diabetic retinopathy and glaucoma. These diseases are the leading causes of visual impairment and blindness all over the world and are associated with many pathological risk factors such as aging, pollution, high levels of glucose (hyperglycaemia), high metabolic rates, and light exposure. These risk factors lead to the generation of uncontrollable reactive oxygen species (ROS), which causes oxidative stress. Oxidative stress plays a crucial role in the pathogenesis of age-related eye diseases through the activation of nuclear factor kappa B (NF-κB), vascular endothelial growth factor (VEGF), and lipid peroxidation, which leads to the production of inflammatory cytokines, angiogenesis, protein and DNA damages, apoptosis that causes macular degeneration (AMD), cataract, diabetic retinopathy and glaucoma. This review provides updated information on the beneficial effects of dietary natural plant products (DPNPs) against age-related eye diseases. In this review, supplementation of DPNPs demonstrated preventive and therapeutic effects on people at risk of or with age-related eye diseases due to their capacity to scavenge free radicals, ameliorate inflammatory molecules, neutralize the oxidation reaction that occurs in photoreceptor cells, decrease vascular endothelial growth factor and the blood-retinal barrier and increase the antioxidant defence system. However, further experiments and clinical trials are required to establish the daily doses of DPNPs that will safely and effectively prevent age-related eye diseases.
format Online
Article
Text
id pubmed-7355812
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-73558122020-07-17 The potential health benefits of dietary natural plant products in age related eye diseases Ikonne, Eleazar Uchenna Ikpeazu, Victor Okezie Ugbogu, Eziuche Amadike Heliyon Review Article In the past decade, there has been a tremendous increase in the number of cases of age-related eye diseases such as age-related macular degeneration (AMD), cataract, diabetic retinopathy and glaucoma. These diseases are the leading causes of visual impairment and blindness all over the world and are associated with many pathological risk factors such as aging, pollution, high levels of glucose (hyperglycaemia), high metabolic rates, and light exposure. These risk factors lead to the generation of uncontrollable reactive oxygen species (ROS), which causes oxidative stress. Oxidative stress plays a crucial role in the pathogenesis of age-related eye diseases through the activation of nuclear factor kappa B (NF-κB), vascular endothelial growth factor (VEGF), and lipid peroxidation, which leads to the production of inflammatory cytokines, angiogenesis, protein and DNA damages, apoptosis that causes macular degeneration (AMD), cataract, diabetic retinopathy and glaucoma. This review provides updated information on the beneficial effects of dietary natural plant products (DPNPs) against age-related eye diseases. In this review, supplementation of DPNPs demonstrated preventive and therapeutic effects on people at risk of or with age-related eye diseases due to their capacity to scavenge free radicals, ameliorate inflammatory molecules, neutralize the oxidation reaction that occurs in photoreceptor cells, decrease vascular endothelial growth factor and the blood-retinal barrier and increase the antioxidant defence system. However, further experiments and clinical trials are required to establish the daily doses of DPNPs that will safely and effectively prevent age-related eye diseases. Elsevier 2020-07-10 /pmc/articles/PMC7355812/ /pubmed/32685729 http://dx.doi.org/10.1016/j.heliyon.2020.e04408 Text en © 2020 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review Article
Ikonne, Eleazar Uchenna
Ikpeazu, Victor Okezie
Ugbogu, Eziuche Amadike
The potential health benefits of dietary natural plant products in age related eye diseases
title The potential health benefits of dietary natural plant products in age related eye diseases
title_full The potential health benefits of dietary natural plant products in age related eye diseases
title_fullStr The potential health benefits of dietary natural plant products in age related eye diseases
title_full_unstemmed The potential health benefits of dietary natural plant products in age related eye diseases
title_short The potential health benefits of dietary natural plant products in age related eye diseases
title_sort potential health benefits of dietary natural plant products in age related eye diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355812/
https://www.ncbi.nlm.nih.gov/pubmed/32685729
http://dx.doi.org/10.1016/j.heliyon.2020.e04408
work_keys_str_mv AT ikonneeleazaruchenna thepotentialhealthbenefitsofdietarynaturalplantproductsinagerelatedeyediseases
AT ikpeazuvictorokezie thepotentialhealthbenefitsofdietarynaturalplantproductsinagerelatedeyediseases
AT ugbogueziucheamadike thepotentialhealthbenefitsofdietarynaturalplantproductsinagerelatedeyediseases
AT ikonneeleazaruchenna potentialhealthbenefitsofdietarynaturalplantproductsinagerelatedeyediseases
AT ikpeazuvictorokezie potentialhealthbenefitsofdietarynaturalplantproductsinagerelatedeyediseases
AT ugbogueziucheamadike potentialhealthbenefitsofdietarynaturalplantproductsinagerelatedeyediseases