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Outcomes of COVID-19 among Patients on In-Center Hemodialysis: An Experience from the Epicenter in South Korea

Patients with advanced chronic kidney disease (CKD) or who are on hemodialysis (HD) could have increased susceptibility to the 2019 coronavirus disease (COVID-19) given their pre-existing comorbidities, older age, compromised immune system, and regular visits to populated outpatient dialysis centers...

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Autores principales: Jung, Hee-Yeon, Lim, Jeong-Hoon, Kang, Seok Hui, Kim, Seong Gyu, Lee, Yong-Hoon, Lee, Jaehee, Chang, Hyun-Ha, Kim, Shin-Woo, Choi, Ji-Young, Cho, Jang-Hee, Kim, Chan-Duck, Kim, Yong-Lim, Park, Sun-Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355817/
https://www.ncbi.nlm.nih.gov/pubmed/32498262
http://dx.doi.org/10.3390/jcm9061688
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author Jung, Hee-Yeon
Lim, Jeong-Hoon
Kang, Seok Hui
Kim, Seong Gyu
Lee, Yong-Hoon
Lee, Jaehee
Chang, Hyun-Ha
Kim, Shin-Woo
Choi, Ji-Young
Cho, Jang-Hee
Kim, Chan-Duck
Kim, Yong-Lim
Park, Sun-Hee
author_facet Jung, Hee-Yeon
Lim, Jeong-Hoon
Kang, Seok Hui
Kim, Seong Gyu
Lee, Yong-Hoon
Lee, Jaehee
Chang, Hyun-Ha
Kim, Shin-Woo
Choi, Ji-Young
Cho, Jang-Hee
Kim, Chan-Duck
Kim, Yong-Lim
Park, Sun-Hee
author_sort Jung, Hee-Yeon
collection PubMed
description Patients with advanced chronic kidney disease (CKD) or who are on hemodialysis (HD) could have increased susceptibility to the 2019 coronavirus disease (COVID-19) given their pre-existing comorbidities, older age, compromised immune system, and regular visits to populated outpatient dialysis centers. This study included 14 consecutive patients on HD or with advanced CKD who initiated HD after being diagnosed with laboratory-confirmed COVID-19 from February to April 2020 in hospitals throughout Daegu, South Korea. The included patients, 42.9% of whom were men, had a mean age of 63.5 years. Four patients had a history of contact with a patient suffering from COVID-19. The most common symptom was cough (50.0%), followed by dyspnea (35.7%). The mean time from symptom onset to diagnosis and admission was 2.6 and 3.5 days, respectively. Patients exhibited lymphopenia and elevated inflammatory markers, including C-reactive protein and ferritin. Chest radiography findings showed pulmonary infiltration in 10 patients. All patients underwent regular HD in a negative pressure room and received antiviral agents. Four patients received mechanical ventilation and continuous renal replacement therapy at a median duration of 14.0 and 8.5 days, respectively. One patient underwent extracorporeal membrane oxygenation for three days. Among the 14 patients included, two died due to acute respiratory distress syndrome, nine were discharged from the hospital, and three remained hospitalized. Despite the high-risk conditions associated with worse outcomes, patients on HD did not exhibit extremely poor overall COVID-19 outcomes perhaps due to early diagnosis, prompt hospitalization, and antiviral therapy.
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spelling pubmed-73558172020-07-23 Outcomes of COVID-19 among Patients on In-Center Hemodialysis: An Experience from the Epicenter in South Korea Jung, Hee-Yeon Lim, Jeong-Hoon Kang, Seok Hui Kim, Seong Gyu Lee, Yong-Hoon Lee, Jaehee Chang, Hyun-Ha Kim, Shin-Woo Choi, Ji-Young Cho, Jang-Hee Kim, Chan-Duck Kim, Yong-Lim Park, Sun-Hee J Clin Med Article Patients with advanced chronic kidney disease (CKD) or who are on hemodialysis (HD) could have increased susceptibility to the 2019 coronavirus disease (COVID-19) given their pre-existing comorbidities, older age, compromised immune system, and regular visits to populated outpatient dialysis centers. This study included 14 consecutive patients on HD or with advanced CKD who initiated HD after being diagnosed with laboratory-confirmed COVID-19 from February to April 2020 in hospitals throughout Daegu, South Korea. The included patients, 42.9% of whom were men, had a mean age of 63.5 years. Four patients had a history of contact with a patient suffering from COVID-19. The most common symptom was cough (50.0%), followed by dyspnea (35.7%). The mean time from symptom onset to diagnosis and admission was 2.6 and 3.5 days, respectively. Patients exhibited lymphopenia and elevated inflammatory markers, including C-reactive protein and ferritin. Chest radiography findings showed pulmonary infiltration in 10 patients. All patients underwent regular HD in a negative pressure room and received antiviral agents. Four patients received mechanical ventilation and continuous renal replacement therapy at a median duration of 14.0 and 8.5 days, respectively. One patient underwent extracorporeal membrane oxygenation for three days. Among the 14 patients included, two died due to acute respiratory distress syndrome, nine were discharged from the hospital, and three remained hospitalized. Despite the high-risk conditions associated with worse outcomes, patients on HD did not exhibit extremely poor overall COVID-19 outcomes perhaps due to early diagnosis, prompt hospitalization, and antiviral therapy. MDPI 2020-06-02 /pmc/articles/PMC7355817/ /pubmed/32498262 http://dx.doi.org/10.3390/jcm9061688 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jung, Hee-Yeon
Lim, Jeong-Hoon
Kang, Seok Hui
Kim, Seong Gyu
Lee, Yong-Hoon
Lee, Jaehee
Chang, Hyun-Ha
Kim, Shin-Woo
Choi, Ji-Young
Cho, Jang-Hee
Kim, Chan-Duck
Kim, Yong-Lim
Park, Sun-Hee
Outcomes of COVID-19 among Patients on In-Center Hemodialysis: An Experience from the Epicenter in South Korea
title Outcomes of COVID-19 among Patients on In-Center Hemodialysis: An Experience from the Epicenter in South Korea
title_full Outcomes of COVID-19 among Patients on In-Center Hemodialysis: An Experience from the Epicenter in South Korea
title_fullStr Outcomes of COVID-19 among Patients on In-Center Hemodialysis: An Experience from the Epicenter in South Korea
title_full_unstemmed Outcomes of COVID-19 among Patients on In-Center Hemodialysis: An Experience from the Epicenter in South Korea
title_short Outcomes of COVID-19 among Patients on In-Center Hemodialysis: An Experience from the Epicenter in South Korea
title_sort outcomes of covid-19 among patients on in-center hemodialysis: an experience from the epicenter in south korea
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355817/
https://www.ncbi.nlm.nih.gov/pubmed/32498262
http://dx.doi.org/10.3390/jcm9061688
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