Challenges and Solutions for Commercial Scale Manufacturing of Allogeneic Pluripotent Stem Cell Products

Allogeneic cell therapy products, such as therapeutic cells derived from pluripotent stem cells (PSCs), have amazing potential to treat a wide variety of diseases and vast numbers of patients globally. However, there are various challenges related to the manufacturing of PSCs in large enough quantit...

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Detalles Bibliográficos
Autores principales: Lee, Brian, Borys, Breanna S., Kallos, Michael S., Rodrigues, Carlos A. V., Silva, Teresa P., Cabral, Joaquim M. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355837/
https://www.ncbi.nlm.nih.gov/pubmed/32231012
http://dx.doi.org/10.3390/bioengineering7020031
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author Lee, Brian
Borys, Breanna S.
Kallos, Michael S.
Rodrigues, Carlos A. V.
Silva, Teresa P.
Cabral, Joaquim M. S.
author_facet Lee, Brian
Borys, Breanna S.
Kallos, Michael S.
Rodrigues, Carlos A. V.
Silva, Teresa P.
Cabral, Joaquim M. S.
author_sort Lee, Brian
collection PubMed
description Allogeneic cell therapy products, such as therapeutic cells derived from pluripotent stem cells (PSCs), have amazing potential to treat a wide variety of diseases and vast numbers of patients globally. However, there are various challenges related to the manufacturing of PSCs in large enough quantities to meet commercial needs. This manuscript addresses the challenges for the process development of PSCs production in a bioreactor, and also presents a scalable bioreactor technology that can be a possible solution to remove the bottleneck for the large-scale manufacturing of high-quality therapeutic cells derived from PSCs.
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spelling pubmed-73558372020-07-23 Challenges and Solutions for Commercial Scale Manufacturing of Allogeneic Pluripotent Stem Cell Products Lee, Brian Borys, Breanna S. Kallos, Michael S. Rodrigues, Carlos A. V. Silva, Teresa P. Cabral, Joaquim M. S. Bioengineering (Basel) Communication Allogeneic cell therapy products, such as therapeutic cells derived from pluripotent stem cells (PSCs), have amazing potential to treat a wide variety of diseases and vast numbers of patients globally. However, there are various challenges related to the manufacturing of PSCs in large enough quantities to meet commercial needs. This manuscript addresses the challenges for the process development of PSCs production in a bioreactor, and also presents a scalable bioreactor technology that can be a possible solution to remove the bottleneck for the large-scale manufacturing of high-quality therapeutic cells derived from PSCs. MDPI 2020-03-28 /pmc/articles/PMC7355837/ /pubmed/32231012 http://dx.doi.org/10.3390/bioengineering7020031 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Lee, Brian
Borys, Breanna S.
Kallos, Michael S.
Rodrigues, Carlos A. V.
Silva, Teresa P.
Cabral, Joaquim M. S.
Challenges and Solutions for Commercial Scale Manufacturing of Allogeneic Pluripotent Stem Cell Products
title Challenges and Solutions for Commercial Scale Manufacturing of Allogeneic Pluripotent Stem Cell Products
title_full Challenges and Solutions for Commercial Scale Manufacturing of Allogeneic Pluripotent Stem Cell Products
title_fullStr Challenges and Solutions for Commercial Scale Manufacturing of Allogeneic Pluripotent Stem Cell Products
title_full_unstemmed Challenges and Solutions for Commercial Scale Manufacturing of Allogeneic Pluripotent Stem Cell Products
title_short Challenges and Solutions for Commercial Scale Manufacturing of Allogeneic Pluripotent Stem Cell Products
title_sort challenges and solutions for commercial scale manufacturing of allogeneic pluripotent stem cell products
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355837/
https://www.ncbi.nlm.nih.gov/pubmed/32231012
http://dx.doi.org/10.3390/bioengineering7020031
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