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Correlation of Pancreatic T1 Values Using Modified Look-Locker Inversion Recovery Sequence (MOLLI) with Pancreatic Exocrine and Endocrine Function

Quantifying myocardial T1 values has been useful for detecting and characterizing fibrotic appearance in myocardial infarction, focal scars, and non-ischemic cardiomyopathies. Since pancreatic exocrine function decreases with chronic pancreatic fibrosis advancement, this study examined the correlati...

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Autores principales: Ashihara, Norihiro, Watanabe, Takayuki, Kako, Satoko, Kuraishi, Yasuhiro, Ozawa, Makiko, Shigefuji, Shohei, Kanai, Keita, Usami, Yoko, Yamada, Akira, Umemura, Takeji, Fujinaga, Yasunari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355870/
https://www.ncbi.nlm.nih.gov/pubmed/32531933
http://dx.doi.org/10.3390/jcm9061805
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author Ashihara, Norihiro
Watanabe, Takayuki
Kako, Satoko
Kuraishi, Yasuhiro
Ozawa, Makiko
Shigefuji, Shohei
Kanai, Keita
Usami, Yoko
Yamada, Akira
Umemura, Takeji
Fujinaga, Yasunari
author_facet Ashihara, Norihiro
Watanabe, Takayuki
Kako, Satoko
Kuraishi, Yasuhiro
Ozawa, Makiko
Shigefuji, Shohei
Kanai, Keita
Usami, Yoko
Yamada, Akira
Umemura, Takeji
Fujinaga, Yasunari
author_sort Ashihara, Norihiro
collection PubMed
description Quantifying myocardial T1 values has been useful for detecting and characterizing fibrotic appearance in myocardial infarction, focal scars, and non-ischemic cardiomyopathies. Since pancreatic exocrine function decreases with chronic pancreatic fibrosis advancement, this study examined the correlation between pancreatic T1 values and pancreatic exocrine and endocrine insufficiency. Methods: Thirty-two patients underwent abdominal contrast-enhanced MRI in our department between October 2017 and February 2019. We evaluated the T1 values of the pancreas using a modified Look-Locker inversion recovery sequence (MOLLI), pancreatic exocrine insufficiency (PEI) by fecal elastase 1 (FE1) values, and pancreatic endocrine insufficiency using fasting insulin and blood glucose levels to calculate the HOMA-β. This trial is registered in the UMIN Clinical Trials Registry as UMIN 000030067. Results: The median cohort (9 males and 23 females) age was 71 (range: 49–84) years. Eighteen patients had pancreatic cysts, three had alcohol-induced chronic pancreatitis, three had pancreatic cancer, and eight possessed other pancreatic features (two patients each with autoimmune pancreatitis, acute pancreatitis, or a bile duct tumor, one with idiopathic chronic pancreatitis, and one healthy control with negative findings). The median pancreatic T1 value measured by the MOLLI was 857.5 ms (597–2569). A significant negative correlation was found between the T1 mapping and FE1 values (r = 0.69, p < 0.01), with none for the T1 with HOMA-β or serum albumin, triglycerides, or body mass index. Conclusions: the pancreatic T1 values correlated significantly with pancreatic exocrine function and might be useful in PEI diagnosis.
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spelling pubmed-73558702020-07-22 Correlation of Pancreatic T1 Values Using Modified Look-Locker Inversion Recovery Sequence (MOLLI) with Pancreatic Exocrine and Endocrine Function Ashihara, Norihiro Watanabe, Takayuki Kako, Satoko Kuraishi, Yasuhiro Ozawa, Makiko Shigefuji, Shohei Kanai, Keita Usami, Yoko Yamada, Akira Umemura, Takeji Fujinaga, Yasunari J Clin Med Article Quantifying myocardial T1 values has been useful for detecting and characterizing fibrotic appearance in myocardial infarction, focal scars, and non-ischemic cardiomyopathies. Since pancreatic exocrine function decreases with chronic pancreatic fibrosis advancement, this study examined the correlation between pancreatic T1 values and pancreatic exocrine and endocrine insufficiency. Methods: Thirty-two patients underwent abdominal contrast-enhanced MRI in our department between October 2017 and February 2019. We evaluated the T1 values of the pancreas using a modified Look-Locker inversion recovery sequence (MOLLI), pancreatic exocrine insufficiency (PEI) by fecal elastase 1 (FE1) values, and pancreatic endocrine insufficiency using fasting insulin and blood glucose levels to calculate the HOMA-β. This trial is registered in the UMIN Clinical Trials Registry as UMIN 000030067. Results: The median cohort (9 males and 23 females) age was 71 (range: 49–84) years. Eighteen patients had pancreatic cysts, three had alcohol-induced chronic pancreatitis, three had pancreatic cancer, and eight possessed other pancreatic features (two patients each with autoimmune pancreatitis, acute pancreatitis, or a bile duct tumor, one with idiopathic chronic pancreatitis, and one healthy control with negative findings). The median pancreatic T1 value measured by the MOLLI was 857.5 ms (597–2569). A significant negative correlation was found between the T1 mapping and FE1 values (r = 0.69, p < 0.01), with none for the T1 with HOMA-β or serum albumin, triglycerides, or body mass index. Conclusions: the pancreatic T1 values correlated significantly with pancreatic exocrine function and might be useful in PEI diagnosis. MDPI 2020-06-10 /pmc/articles/PMC7355870/ /pubmed/32531933 http://dx.doi.org/10.3390/jcm9061805 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ashihara, Norihiro
Watanabe, Takayuki
Kako, Satoko
Kuraishi, Yasuhiro
Ozawa, Makiko
Shigefuji, Shohei
Kanai, Keita
Usami, Yoko
Yamada, Akira
Umemura, Takeji
Fujinaga, Yasunari
Correlation of Pancreatic T1 Values Using Modified Look-Locker Inversion Recovery Sequence (MOLLI) with Pancreatic Exocrine and Endocrine Function
title Correlation of Pancreatic T1 Values Using Modified Look-Locker Inversion Recovery Sequence (MOLLI) with Pancreatic Exocrine and Endocrine Function
title_full Correlation of Pancreatic T1 Values Using Modified Look-Locker Inversion Recovery Sequence (MOLLI) with Pancreatic Exocrine and Endocrine Function
title_fullStr Correlation of Pancreatic T1 Values Using Modified Look-Locker Inversion Recovery Sequence (MOLLI) with Pancreatic Exocrine and Endocrine Function
title_full_unstemmed Correlation of Pancreatic T1 Values Using Modified Look-Locker Inversion Recovery Sequence (MOLLI) with Pancreatic Exocrine and Endocrine Function
title_short Correlation of Pancreatic T1 Values Using Modified Look-Locker Inversion Recovery Sequence (MOLLI) with Pancreatic Exocrine and Endocrine Function
title_sort correlation of pancreatic t1 values using modified look-locker inversion recovery sequence (molli) with pancreatic exocrine and endocrine function
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355870/
https://www.ncbi.nlm.nih.gov/pubmed/32531933
http://dx.doi.org/10.3390/jcm9061805
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