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Chronic Gastritis Is Associated with a Decreased High-Density Lipid Level: Histological Features of Gastritis Based on the Updated Sydney System

Chronic gastritis could activate a systemic inflammatory response that could result in adverse lipid profiles. To determine the severity of chronic gastritis, Helicobacter pylori (HP), mononuclear cell (lymphocytes and plasma cells), and neutrophil scores were assessed on the basis of the updated Sy...

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Autores principales: Kim, Dong-Hoon, Son, Byoung Kwan, Min, Kyueng-Whan, Han, Sang Kuk, Na, Ji Ung, Choi, Pil Cho, Kim, Hack-Lyoung, Kwon, Mi Jung, Oh, Young Ha, Jung, Woon Yong, Moon, Ji-Yong, Hong, Sangmo, Oh, Ki-Wook, Kim, Young Seo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355915/
https://www.ncbi.nlm.nih.gov/pubmed/32545889
http://dx.doi.org/10.3390/jcm9061856
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author Kim, Dong-Hoon
Son, Byoung Kwan
Min, Kyueng-Whan
Han, Sang Kuk
Na, Ji Ung
Choi, Pil Cho
Kim, Hack-Lyoung
Kwon, Mi Jung
Oh, Young Ha
Jung, Woon Yong
Moon, Ji-Yong
Hong, Sangmo
Oh, Ki-Wook
Kim, Young Seo
author_facet Kim, Dong-Hoon
Son, Byoung Kwan
Min, Kyueng-Whan
Han, Sang Kuk
Na, Ji Ung
Choi, Pil Cho
Kim, Hack-Lyoung
Kwon, Mi Jung
Oh, Young Ha
Jung, Woon Yong
Moon, Ji-Yong
Hong, Sangmo
Oh, Ki-Wook
Kim, Young Seo
author_sort Kim, Dong-Hoon
collection PubMed
description Chronic gastritis could activate a systemic inflammatory response that could result in adverse lipid profiles. To determine the severity of chronic gastritis, Helicobacter pylori (HP), mononuclear cell (lymphocytes and plasma cells), and neutrophil scores were assessed on the basis of the updated Sydney system (USS), which is widely used for histological grading. The aim of this study was to assess the relationships between gastric histological features and lipid profile levels. This study included 15,322 males and 5929 females who underwent a health checkup and gastric biopsy at the Kangbuk Samsung Medical Center (KBSMC). We analyzed whether the HP, mononuclear cell, and neutrophil grades according to the USS were related to serum leukocyte count, unhealthy behaviors, and lipid profile levels. Gastritis with HP, neutrophils, or moderate to severe mononuclear cells was associated with an elevated serum leukocyte count. A high leukocyte count was related to increased low-density lipoproteins (LDL) and triglycerides/very-low-density lipoprotein (VLDL) and decreased high-density lipoproteins (HDL). In multivariate analyses, chronic gastritis with HP or moderate to severe mononuclear cells was significantly associated with decreased HDL in males, while mononuclear cells were significantly related to decreased HDL in females. Chronic gastritis was associated with an increased systemic inflammatory response, which was associated with unfavorable lipid profiles, especially low HDL levels.
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spelling pubmed-73559152020-07-22 Chronic Gastritis Is Associated with a Decreased High-Density Lipid Level: Histological Features of Gastritis Based on the Updated Sydney System Kim, Dong-Hoon Son, Byoung Kwan Min, Kyueng-Whan Han, Sang Kuk Na, Ji Ung Choi, Pil Cho Kim, Hack-Lyoung Kwon, Mi Jung Oh, Young Ha Jung, Woon Yong Moon, Ji-Yong Hong, Sangmo Oh, Ki-Wook Kim, Young Seo J Clin Med Article Chronic gastritis could activate a systemic inflammatory response that could result in adverse lipid profiles. To determine the severity of chronic gastritis, Helicobacter pylori (HP), mononuclear cell (lymphocytes and plasma cells), and neutrophil scores were assessed on the basis of the updated Sydney system (USS), which is widely used for histological grading. The aim of this study was to assess the relationships between gastric histological features and lipid profile levels. This study included 15,322 males and 5929 females who underwent a health checkup and gastric biopsy at the Kangbuk Samsung Medical Center (KBSMC). We analyzed whether the HP, mononuclear cell, and neutrophil grades according to the USS were related to serum leukocyte count, unhealthy behaviors, and lipid profile levels. Gastritis with HP, neutrophils, or moderate to severe mononuclear cells was associated with an elevated serum leukocyte count. A high leukocyte count was related to increased low-density lipoproteins (LDL) and triglycerides/very-low-density lipoprotein (VLDL) and decreased high-density lipoproteins (HDL). In multivariate analyses, chronic gastritis with HP or moderate to severe mononuclear cells was significantly associated with decreased HDL in males, while mononuclear cells were significantly related to decreased HDL in females. Chronic gastritis was associated with an increased systemic inflammatory response, which was associated with unfavorable lipid profiles, especially low HDL levels. MDPI 2020-06-14 /pmc/articles/PMC7355915/ /pubmed/32545889 http://dx.doi.org/10.3390/jcm9061856 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kim, Dong-Hoon
Son, Byoung Kwan
Min, Kyueng-Whan
Han, Sang Kuk
Na, Ji Ung
Choi, Pil Cho
Kim, Hack-Lyoung
Kwon, Mi Jung
Oh, Young Ha
Jung, Woon Yong
Moon, Ji-Yong
Hong, Sangmo
Oh, Ki-Wook
Kim, Young Seo
Chronic Gastritis Is Associated with a Decreased High-Density Lipid Level: Histological Features of Gastritis Based on the Updated Sydney System
title Chronic Gastritis Is Associated with a Decreased High-Density Lipid Level: Histological Features of Gastritis Based on the Updated Sydney System
title_full Chronic Gastritis Is Associated with a Decreased High-Density Lipid Level: Histological Features of Gastritis Based on the Updated Sydney System
title_fullStr Chronic Gastritis Is Associated with a Decreased High-Density Lipid Level: Histological Features of Gastritis Based on the Updated Sydney System
title_full_unstemmed Chronic Gastritis Is Associated with a Decreased High-Density Lipid Level: Histological Features of Gastritis Based on the Updated Sydney System
title_short Chronic Gastritis Is Associated with a Decreased High-Density Lipid Level: Histological Features of Gastritis Based on the Updated Sydney System
title_sort chronic gastritis is associated with a decreased high-density lipid level: histological features of gastritis based on the updated sydney system
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355915/
https://www.ncbi.nlm.nih.gov/pubmed/32545889
http://dx.doi.org/10.3390/jcm9061856
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