The Citrus Flavonoid Hesperetin Has an Inadequate Anti-Arrhythmic Profile in the ΔKPQ Na(V)1.5 Mutant of the Long QT Type 3 Syndrome

Type 3 long QT syndromes (LQT3) are associated with arrhythmogenic gain-of-function mutations in the cardiac voltage-gated Na(+) channel (hNa(V)1.5). The citrus flavanone hesperetin (HSP) was previously suggested as a template molecule to develop new anti-arrhythmic drugs, as it blocks slowly-inacti...

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Detalles Bibliográficos
Autores principales: Alvarez-Collazo, Julio, López-Requena, Alejandro, Alvarez, Julio L., Talavera, Karel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355927/
https://www.ncbi.nlm.nih.gov/pubmed/32599724
http://dx.doi.org/10.3390/biom10060952

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355927/
https://www.ncbi.nlm.nih.gov/pubmed/32599724
http://dx.doi.org/10.3390/biom10060952

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