Structure-Based Discovery of Dual-Target Hits for Acetylcholinesterase and the α7 Nicotinic Acetylcholine Receptors: In Silico Studies and In Vitro Confirmation

Despite extensive efforts in the development of drugs for complex neurodegenerative diseases, treatment often remains challenging or ineffective, and hence new treatment strategies are necessary. One approach is the design of multi-target drugs, which can potentially address the complex nature of di...

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Detalles Bibliográficos
Autores principales: Oddsson, Sebastian, Kowal, Natalia M., Ahring, Philip K., Olafsdottir, Elin S., Balle, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355937/
https://www.ncbi.nlm.nih.gov/pubmed/32580406
http://dx.doi.org/10.3390/molecules25122872

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355937/
https://www.ncbi.nlm.nih.gov/pubmed/32580406
http://dx.doi.org/10.3390/molecules25122872

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