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Validation of Pharmacological Protocols for Targeted Inhibition of Canalicular MRP2 Activity in Hepatocytes Using [(99m)Tc]mebrofenin Imaging in Rats

The multidrug resistance-associated protein 2 (MRP2) mediates the biliary excretion of drugs and metabolites. [(99m)Tc]mebrofenin may be employed as a probe for hepatic MRP2 activity because its biliary excretion is predominantly mediated by this transporter. As the liver uptake of [(99m)Tc]mebrofen...

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Detalles Bibliográficos
Autores principales:	Marie, Solène, Hernández-Lozano, Irene, Breuil, Louise, Saba, Wadad, Novell, Anthony, Gennisson, Jean-Luc, Langer, Oliver, Truillet, Charles, Tournier, Nicolas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355955/ https://www.ncbi.nlm.nih.gov/pubmed/32471244 http://dx.doi.org/10.3390/pharmaceutics12060486

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