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Rapidly Separable Micropillar Integrated Dissolving Microneedles

Dissolving microneedle (DMN) patches were developed as efficient and patient-friendly transdermal delivery systems for biopharmaceuticals. However, recent studies have confirmed that the efficiency of DMNs to deliver biopharmaceuticals is highly reduced because of incomplete insertion caused by the...

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Autores principales: Jung, Chung-ryong, Lahiji, Shayan Fakhraei, Kim, Youseong, Kim, Hyeonjun, Jung, Hyungil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356013/
https://www.ncbi.nlm.nih.gov/pubmed/32585966
http://dx.doi.org/10.3390/pharmaceutics12060581
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author Jung, Chung-ryong
Lahiji, Shayan Fakhraei
Kim, Youseong
Kim, Hyeonjun
Jung, Hyungil
author_facet Jung, Chung-ryong
Lahiji, Shayan Fakhraei
Kim, Youseong
Kim, Hyeonjun
Jung, Hyungil
author_sort Jung, Chung-ryong
collection PubMed
description Dissolving microneedle (DMN) patches were developed as efficient and patient-friendly transdermal delivery systems for biopharmaceuticals. However, recent studies have confirmed that the efficiency of DMNs to deliver biopharmaceuticals is highly reduced because of incomplete insertion caused by the stiffness and elastic properties of the skin. Therefore, micropillar integrated DMNs were developed to overcome the insertion limitations of DMN patches. Although micropillars were designed as integrated applicators to implant DMNs across the skin, they can also become inserted into the skin, leading to skin injury and inflammation. Herein, we have developed a separable micropillar integrated DMN (SPDMN) capable of inserting DMNs across the skin with high efficiency while minimizing skin injury risk through the introduction of a safety ring feature. Unlike previously developed systems, the SPDMN does not require continuous skin attachment and can be detached immediately post-application, leaving DMNs implanted inside the skin. Altogether, the findings of this study lead to the development of a quick, safe, and efficient DMN-based drug delivery platform.
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spelling pubmed-73560132020-07-22 Rapidly Separable Micropillar Integrated Dissolving Microneedles Jung, Chung-ryong Lahiji, Shayan Fakhraei Kim, Youseong Kim, Hyeonjun Jung, Hyungil Pharmaceutics Article Dissolving microneedle (DMN) patches were developed as efficient and patient-friendly transdermal delivery systems for biopharmaceuticals. However, recent studies have confirmed that the efficiency of DMNs to deliver biopharmaceuticals is highly reduced because of incomplete insertion caused by the stiffness and elastic properties of the skin. Therefore, micropillar integrated DMNs were developed to overcome the insertion limitations of DMN patches. Although micropillars were designed as integrated applicators to implant DMNs across the skin, they can also become inserted into the skin, leading to skin injury and inflammation. Herein, we have developed a separable micropillar integrated DMN (SPDMN) capable of inserting DMNs across the skin with high efficiency while minimizing skin injury risk through the introduction of a safety ring feature. Unlike previously developed systems, the SPDMN does not require continuous skin attachment and can be detached immediately post-application, leaving DMNs implanted inside the skin. Altogether, the findings of this study lead to the development of a quick, safe, and efficient DMN-based drug delivery platform. MDPI 2020-06-23 /pmc/articles/PMC7356013/ /pubmed/32585966 http://dx.doi.org/10.3390/pharmaceutics12060581 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jung, Chung-ryong
Lahiji, Shayan Fakhraei
Kim, Youseong
Kim, Hyeonjun
Jung, Hyungil
Rapidly Separable Micropillar Integrated Dissolving Microneedles
title Rapidly Separable Micropillar Integrated Dissolving Microneedles
title_full Rapidly Separable Micropillar Integrated Dissolving Microneedles
title_fullStr Rapidly Separable Micropillar Integrated Dissolving Microneedles
title_full_unstemmed Rapidly Separable Micropillar Integrated Dissolving Microneedles
title_short Rapidly Separable Micropillar Integrated Dissolving Microneedles
title_sort rapidly separable micropillar integrated dissolving microneedles
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356013/
https://www.ncbi.nlm.nih.gov/pubmed/32585966
http://dx.doi.org/10.3390/pharmaceutics12060581
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