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Rapidly Separable Micropillar Integrated Dissolving Microneedles
Dissolving microneedle (DMN) patches were developed as efficient and patient-friendly transdermal delivery systems for biopharmaceuticals. However, recent studies have confirmed that the efficiency of DMNs to deliver biopharmaceuticals is highly reduced because of incomplete insertion caused by the...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356013/ https://www.ncbi.nlm.nih.gov/pubmed/32585966 http://dx.doi.org/10.3390/pharmaceutics12060581 |
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author | Jung, Chung-ryong Lahiji, Shayan Fakhraei Kim, Youseong Kim, Hyeonjun Jung, Hyungil |
author_facet | Jung, Chung-ryong Lahiji, Shayan Fakhraei Kim, Youseong Kim, Hyeonjun Jung, Hyungil |
author_sort | Jung, Chung-ryong |
collection | PubMed |
description | Dissolving microneedle (DMN) patches were developed as efficient and patient-friendly transdermal delivery systems for biopharmaceuticals. However, recent studies have confirmed that the efficiency of DMNs to deliver biopharmaceuticals is highly reduced because of incomplete insertion caused by the stiffness and elastic properties of the skin. Therefore, micropillar integrated DMNs were developed to overcome the insertion limitations of DMN patches. Although micropillars were designed as integrated applicators to implant DMNs across the skin, they can also become inserted into the skin, leading to skin injury and inflammation. Herein, we have developed a separable micropillar integrated DMN (SPDMN) capable of inserting DMNs across the skin with high efficiency while minimizing skin injury risk through the introduction of a safety ring feature. Unlike previously developed systems, the SPDMN does not require continuous skin attachment and can be detached immediately post-application, leaving DMNs implanted inside the skin. Altogether, the findings of this study lead to the development of a quick, safe, and efficient DMN-based drug delivery platform. |
format | Online Article Text |
id | pubmed-7356013 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-73560132020-07-22 Rapidly Separable Micropillar Integrated Dissolving Microneedles Jung, Chung-ryong Lahiji, Shayan Fakhraei Kim, Youseong Kim, Hyeonjun Jung, Hyungil Pharmaceutics Article Dissolving microneedle (DMN) patches were developed as efficient and patient-friendly transdermal delivery systems for biopharmaceuticals. However, recent studies have confirmed that the efficiency of DMNs to deliver biopharmaceuticals is highly reduced because of incomplete insertion caused by the stiffness and elastic properties of the skin. Therefore, micropillar integrated DMNs were developed to overcome the insertion limitations of DMN patches. Although micropillars were designed as integrated applicators to implant DMNs across the skin, they can also become inserted into the skin, leading to skin injury and inflammation. Herein, we have developed a separable micropillar integrated DMN (SPDMN) capable of inserting DMNs across the skin with high efficiency while minimizing skin injury risk through the introduction of a safety ring feature. Unlike previously developed systems, the SPDMN does not require continuous skin attachment and can be detached immediately post-application, leaving DMNs implanted inside the skin. Altogether, the findings of this study lead to the development of a quick, safe, and efficient DMN-based drug delivery platform. MDPI 2020-06-23 /pmc/articles/PMC7356013/ /pubmed/32585966 http://dx.doi.org/10.3390/pharmaceutics12060581 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Jung, Chung-ryong Lahiji, Shayan Fakhraei Kim, Youseong Kim, Hyeonjun Jung, Hyungil Rapidly Separable Micropillar Integrated Dissolving Microneedles |
title | Rapidly Separable Micropillar Integrated Dissolving Microneedles |
title_full | Rapidly Separable Micropillar Integrated Dissolving Microneedles |
title_fullStr | Rapidly Separable Micropillar Integrated Dissolving Microneedles |
title_full_unstemmed | Rapidly Separable Micropillar Integrated Dissolving Microneedles |
title_short | Rapidly Separable Micropillar Integrated Dissolving Microneedles |
title_sort | rapidly separable micropillar integrated dissolving microneedles |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356013/ https://www.ncbi.nlm.nih.gov/pubmed/32585966 http://dx.doi.org/10.3390/pharmaceutics12060581 |
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