Taurine and Ginsenoside Rf Induce BDNF Expression in SH-SY5Y Cells: A Potential Role of BDNF in Corticosterone-Triggered Cellular Damage

This study shows that taurine and ginsenoside Rf act synergistically to increase the expression of brain-derived neurotrophic factor (BDNF) in SH-SY5Y human neuroblastoma cells in a dose- and time-dependent manner. The increase of BDNF mRNA by taurine and ginsenoside Rf was markedly attenuated by in...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Won Jin, Lee, Gyeong Hee, Hur, Jinwoo, Lee, Hyuk Gyoon, Kim, Eunsu, Won, Jun Pil, Cho, Youngjae, Choi, Mi-Jung, Seo, Han Geuk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356094/
https://www.ncbi.nlm.nih.gov/pubmed/32570881
http://dx.doi.org/10.3390/molecules25122819
_version_ 1783558420297678848
author Lee, Won Jin
Lee, Gyeong Hee
Hur, Jinwoo
Lee, Hyuk Gyoon
Kim, Eunsu
Won, Jun Pil
Cho, Youngjae
Choi, Mi-Jung
Seo, Han Geuk
author_facet Lee, Won Jin
Lee, Gyeong Hee
Hur, Jinwoo
Lee, Hyuk Gyoon
Kim, Eunsu
Won, Jun Pil
Cho, Youngjae
Choi, Mi-Jung
Seo, Han Geuk
author_sort Lee, Won Jin
collection PubMed
description This study shows that taurine and ginsenoside Rf act synergistically to increase the expression of brain-derived neurotrophic factor (BDNF) in SH-SY5Y human neuroblastoma cells in a dose- and time-dependent manner. The increase of BDNF mRNA by taurine and ginsenoside Rf was markedly attenuated by inhibitors of extracellular signal-regulated kinase and p38 mitogen-activated protein kinase. In addition, taurine and ginsenoside Rf protected cells from corticosterone-induced BDNF suppression and reduced cell viability and lactate dehydrogenase release. The results from this study showed that combined treatment with both taurine and ginsenoside Rf enhanced BDNF expression and protected cells against corticosterone-induced damage.
format Online
Article
Text
id pubmed-7356094
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-73560942020-07-31 Taurine and Ginsenoside Rf Induce BDNF Expression in SH-SY5Y Cells: A Potential Role of BDNF in Corticosterone-Triggered Cellular Damage Lee, Won Jin Lee, Gyeong Hee Hur, Jinwoo Lee, Hyuk Gyoon Kim, Eunsu Won, Jun Pil Cho, Youngjae Choi, Mi-Jung Seo, Han Geuk Molecules Article This study shows that taurine and ginsenoside Rf act synergistically to increase the expression of brain-derived neurotrophic factor (BDNF) in SH-SY5Y human neuroblastoma cells in a dose- and time-dependent manner. The increase of BDNF mRNA by taurine and ginsenoside Rf was markedly attenuated by inhibitors of extracellular signal-regulated kinase and p38 mitogen-activated protein kinase. In addition, taurine and ginsenoside Rf protected cells from corticosterone-induced BDNF suppression and reduced cell viability and lactate dehydrogenase release. The results from this study showed that combined treatment with both taurine and ginsenoside Rf enhanced BDNF expression and protected cells against corticosterone-induced damage. MDPI 2020-06-18 /pmc/articles/PMC7356094/ /pubmed/32570881 http://dx.doi.org/10.3390/molecules25122819 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lee, Won Jin
Lee, Gyeong Hee
Hur, Jinwoo
Lee, Hyuk Gyoon
Kim, Eunsu
Won, Jun Pil
Cho, Youngjae
Choi, Mi-Jung
Seo, Han Geuk
Taurine and Ginsenoside Rf Induce BDNF Expression in SH-SY5Y Cells: A Potential Role of BDNF in Corticosterone-Triggered Cellular Damage
title Taurine and Ginsenoside Rf Induce BDNF Expression in SH-SY5Y Cells: A Potential Role of BDNF in Corticosterone-Triggered Cellular Damage
title_full Taurine and Ginsenoside Rf Induce BDNF Expression in SH-SY5Y Cells: A Potential Role of BDNF in Corticosterone-Triggered Cellular Damage
title_fullStr Taurine and Ginsenoside Rf Induce BDNF Expression in SH-SY5Y Cells: A Potential Role of BDNF in Corticosterone-Triggered Cellular Damage
title_full_unstemmed Taurine and Ginsenoside Rf Induce BDNF Expression in SH-SY5Y Cells: A Potential Role of BDNF in Corticosterone-Triggered Cellular Damage
title_short Taurine and Ginsenoside Rf Induce BDNF Expression in SH-SY5Y Cells: A Potential Role of BDNF in Corticosterone-Triggered Cellular Damage
title_sort taurine and ginsenoside rf induce bdnf expression in sh-sy5y cells: a potential role of bdnf in corticosterone-triggered cellular damage
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356094/
https://www.ncbi.nlm.nih.gov/pubmed/32570881
http://dx.doi.org/10.3390/molecules25122819
work_keys_str_mv AT leewonjin taurineandginsenosiderfinducebdnfexpressioninshsy5ycellsapotentialroleofbdnfincorticosteronetriggeredcellulardamage
AT leegyeonghee taurineandginsenosiderfinducebdnfexpressioninshsy5ycellsapotentialroleofbdnfincorticosteronetriggeredcellulardamage
AT hurjinwoo taurineandginsenosiderfinducebdnfexpressioninshsy5ycellsapotentialroleofbdnfincorticosteronetriggeredcellulardamage
AT leehyukgyoon taurineandginsenosiderfinducebdnfexpressioninshsy5ycellsapotentialroleofbdnfincorticosteronetriggeredcellulardamage
AT kimeunsu taurineandginsenosiderfinducebdnfexpressioninshsy5ycellsapotentialroleofbdnfincorticosteronetriggeredcellulardamage
AT wonjunpil taurineandginsenosiderfinducebdnfexpressioninshsy5ycellsapotentialroleofbdnfincorticosteronetriggeredcellulardamage
AT choyoungjae taurineandginsenosiderfinducebdnfexpressioninshsy5ycellsapotentialroleofbdnfincorticosteronetriggeredcellulardamage
AT choimijung taurineandginsenosiderfinducebdnfexpressioninshsy5ycellsapotentialroleofbdnfincorticosteronetriggeredcellulardamage
AT seohangeuk taurineandginsenosiderfinducebdnfexpressioninshsy5ycellsapotentialroleofbdnfincorticosteronetriggeredcellulardamage

Ejemplares similares