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Fecal Microbiota Transplantation: Screening and Selection to Choose the Optimal Donor
In the past decade, fecal microbiota transplantation (FMT) has rapidly spread worldwide in clinical practice as a highly effective treatment option against recurrent Clostridioides difficile infection. Moreover, new evidence also supports a role for FMT in other conditions, such as inflammatory bowe...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356099/ https://www.ncbi.nlm.nih.gov/pubmed/32517023 http://dx.doi.org/10.3390/jcm9061757 |
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author | Bibbò, Stefano Settanni, Carlo Romano Porcari, Serena Bocchino, Enrico Ianiro, Gianluca Cammarota, Giovanni Gasbarrini, Antonio |
author_facet | Bibbò, Stefano Settanni, Carlo Romano Porcari, Serena Bocchino, Enrico Ianiro, Gianluca Cammarota, Giovanni Gasbarrini, Antonio |
author_sort | Bibbò, Stefano |
collection | PubMed |
description | In the past decade, fecal microbiota transplantation (FMT) has rapidly spread worldwide in clinical practice as a highly effective treatment option against recurrent Clostridioides difficile infection. Moreover, new evidence also supports a role for FMT in other conditions, such as inflammatory bowel disease, functional gastrointestinal disorders, or metabolic disorders. Recently, some studies have identified specific microbial characteristics associated with clinical improvement after FMT, in different disorders, paving the way for a microbiota-based precision medicine approach. Moreover, donor screening has become increasingly more complex over years, along with standardization of FMT and the increasing number of stool banks. In this narrative review, we discuss most recent evidence on the screening and selection of the stool donor, with reference to recent studies that have identified specific microbiological features for clinical conditions such as Clostridioides difficile infection, irritable bowel syndrome, inflammatory bowel disease, and metabolic disorders. |
format | Online Article Text |
id | pubmed-7356099 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-73560992020-07-31 Fecal Microbiota Transplantation: Screening and Selection to Choose the Optimal Donor Bibbò, Stefano Settanni, Carlo Romano Porcari, Serena Bocchino, Enrico Ianiro, Gianluca Cammarota, Giovanni Gasbarrini, Antonio J Clin Med Review In the past decade, fecal microbiota transplantation (FMT) has rapidly spread worldwide in clinical practice as a highly effective treatment option against recurrent Clostridioides difficile infection. Moreover, new evidence also supports a role for FMT in other conditions, such as inflammatory bowel disease, functional gastrointestinal disorders, or metabolic disorders. Recently, some studies have identified specific microbial characteristics associated with clinical improvement after FMT, in different disorders, paving the way for a microbiota-based precision medicine approach. Moreover, donor screening has become increasingly more complex over years, along with standardization of FMT and the increasing number of stool banks. In this narrative review, we discuss most recent evidence on the screening and selection of the stool donor, with reference to recent studies that have identified specific microbiological features for clinical conditions such as Clostridioides difficile infection, irritable bowel syndrome, inflammatory bowel disease, and metabolic disorders. MDPI 2020-06-05 /pmc/articles/PMC7356099/ /pubmed/32517023 http://dx.doi.org/10.3390/jcm9061757 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Bibbò, Stefano Settanni, Carlo Romano Porcari, Serena Bocchino, Enrico Ianiro, Gianluca Cammarota, Giovanni Gasbarrini, Antonio Fecal Microbiota Transplantation: Screening and Selection to Choose the Optimal Donor |
title | Fecal Microbiota Transplantation: Screening and Selection to Choose the Optimal Donor |
title_full | Fecal Microbiota Transplantation: Screening and Selection to Choose the Optimal Donor |
title_fullStr | Fecal Microbiota Transplantation: Screening and Selection to Choose the Optimal Donor |
title_full_unstemmed | Fecal Microbiota Transplantation: Screening and Selection to Choose the Optimal Donor |
title_short | Fecal Microbiota Transplantation: Screening and Selection to Choose the Optimal Donor |
title_sort | fecal microbiota transplantation: screening and selection to choose the optimal donor |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356099/ https://www.ncbi.nlm.nih.gov/pubmed/32517023 http://dx.doi.org/10.3390/jcm9061757 |
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