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Fecal Microbiota Transplantation: Screening and Selection to Choose the Optimal Donor

In the past decade, fecal microbiota transplantation (FMT) has rapidly spread worldwide in clinical practice as a highly effective treatment option against recurrent Clostridioides difficile infection. Moreover, new evidence also supports a role for FMT in other conditions, such as inflammatory bowe...

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Detalles Bibliográficos
Autores principales: Bibbò, Stefano, Settanni, Carlo Romano, Porcari, Serena, Bocchino, Enrico, Ianiro, Gianluca, Cammarota, Giovanni, Gasbarrini, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356099/
https://www.ncbi.nlm.nih.gov/pubmed/32517023
http://dx.doi.org/10.3390/jcm9061757
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author Bibbò, Stefano
Settanni, Carlo Romano
Porcari, Serena
Bocchino, Enrico
Ianiro, Gianluca
Cammarota, Giovanni
Gasbarrini, Antonio
author_facet Bibbò, Stefano
Settanni, Carlo Romano
Porcari, Serena
Bocchino, Enrico
Ianiro, Gianluca
Cammarota, Giovanni
Gasbarrini, Antonio
author_sort Bibbò, Stefano
collection PubMed
description In the past decade, fecal microbiota transplantation (FMT) has rapidly spread worldwide in clinical practice as a highly effective treatment option against recurrent Clostridioides difficile infection. Moreover, new evidence also supports a role for FMT in other conditions, such as inflammatory bowel disease, functional gastrointestinal disorders, or metabolic disorders. Recently, some studies have identified specific microbial characteristics associated with clinical improvement after FMT, in different disorders, paving the way for a microbiota-based precision medicine approach. Moreover, donor screening has become increasingly more complex over years, along with standardization of FMT and the increasing number of stool banks. In this narrative review, we discuss most recent evidence on the screening and selection of the stool donor, with reference to recent studies that have identified specific microbiological features for clinical conditions such as Clostridioides difficile infection, irritable bowel syndrome, inflammatory bowel disease, and metabolic disorders.
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spelling pubmed-73560992020-07-31 Fecal Microbiota Transplantation: Screening and Selection to Choose the Optimal Donor Bibbò, Stefano Settanni, Carlo Romano Porcari, Serena Bocchino, Enrico Ianiro, Gianluca Cammarota, Giovanni Gasbarrini, Antonio J Clin Med Review In the past decade, fecal microbiota transplantation (FMT) has rapidly spread worldwide in clinical practice as a highly effective treatment option against recurrent Clostridioides difficile infection. Moreover, new evidence also supports a role for FMT in other conditions, such as inflammatory bowel disease, functional gastrointestinal disorders, or metabolic disorders. Recently, some studies have identified specific microbial characteristics associated with clinical improvement after FMT, in different disorders, paving the way for a microbiota-based precision medicine approach. Moreover, donor screening has become increasingly more complex over years, along with standardization of FMT and the increasing number of stool banks. In this narrative review, we discuss most recent evidence on the screening and selection of the stool donor, with reference to recent studies that have identified specific microbiological features for clinical conditions such as Clostridioides difficile infection, irritable bowel syndrome, inflammatory bowel disease, and metabolic disorders. MDPI 2020-06-05 /pmc/articles/PMC7356099/ /pubmed/32517023 http://dx.doi.org/10.3390/jcm9061757 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bibbò, Stefano
Settanni, Carlo Romano
Porcari, Serena
Bocchino, Enrico
Ianiro, Gianluca
Cammarota, Giovanni
Gasbarrini, Antonio
Fecal Microbiota Transplantation: Screening and Selection to Choose the Optimal Donor
title Fecal Microbiota Transplantation: Screening and Selection to Choose the Optimal Donor
title_full Fecal Microbiota Transplantation: Screening and Selection to Choose the Optimal Donor
title_fullStr Fecal Microbiota Transplantation: Screening and Selection to Choose the Optimal Donor
title_full_unstemmed Fecal Microbiota Transplantation: Screening and Selection to Choose the Optimal Donor
title_short Fecal Microbiota Transplantation: Screening and Selection to Choose the Optimal Donor
title_sort fecal microbiota transplantation: screening and selection to choose the optimal donor
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356099/
https://www.ncbi.nlm.nih.gov/pubmed/32517023
http://dx.doi.org/10.3390/jcm9061757
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