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Stress proteins: the biological functions in virus infection, present and challenges for target-based antiviral drug development
Stress proteins (SPs) including heat-shock proteins (HSPs), RNA chaperones, and ER associated stress proteins are molecular chaperones essential for cellular homeostasis. The major functions of HSPs include chaperoning misfolded or unfolded polypeptides, protecting cells from toxic stress, and prese...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356129/ https://www.ncbi.nlm.nih.gov/pubmed/32661235 http://dx.doi.org/10.1038/s41392-020-00233-4 |
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author | Wan, Qianya Song, Dan Li, Huangcan He, Ming-liang |
author_facet | Wan, Qianya Song, Dan Li, Huangcan He, Ming-liang |
author_sort | Wan, Qianya |
collection | PubMed |
description | Stress proteins (SPs) including heat-shock proteins (HSPs), RNA chaperones, and ER associated stress proteins are molecular chaperones essential for cellular homeostasis. The major functions of HSPs include chaperoning misfolded or unfolded polypeptides, protecting cells from toxic stress, and presenting immune and inflammatory cytokines. Regarded as a double-edged sword, HSPs also cooperate with numerous viruses and cancer cells to promote their survival. RNA chaperones are a group of heterogeneous nuclear ribonucleoproteins (hnRNPs), which are essential factors for manipulating both the functions and metabolisms of pre-mRNAs/hnRNAs transcribed by RNA polymerase II. hnRNPs involve in a large number of cellular processes, including chromatin remodelling, transcription regulation, RNP assembly and stabilization, RNA export, virus replication, histone-like nucleoid structuring, and even intracellular immunity. Dysregulation of stress proteins is associated with many human diseases including human cancer, cardiovascular diseases, neurodegenerative diseases (e.g., Parkinson’s diseases, Alzheimer disease), stroke and infectious diseases. In this review, we summarized the biologic function of stress proteins, and current progress on their mechanisms related to virus reproduction and diseases caused by virus infections. As SPs also attract a great interest as potential antiviral targets (e.g., COVID-19), we also discuss the present progress and challenges in this area of HSP-based drug development, as well as with compounds already under clinical evaluation. |
format | Online Article Text |
id | pubmed-7356129 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-73561292020-07-13 Stress proteins: the biological functions in virus infection, present and challenges for target-based antiviral drug development Wan, Qianya Song, Dan Li, Huangcan He, Ming-liang Signal Transduct Target Ther Review Article Stress proteins (SPs) including heat-shock proteins (HSPs), RNA chaperones, and ER associated stress proteins are molecular chaperones essential for cellular homeostasis. The major functions of HSPs include chaperoning misfolded or unfolded polypeptides, protecting cells from toxic stress, and presenting immune and inflammatory cytokines. Regarded as a double-edged sword, HSPs also cooperate with numerous viruses and cancer cells to promote their survival. RNA chaperones are a group of heterogeneous nuclear ribonucleoproteins (hnRNPs), which are essential factors for manipulating both the functions and metabolisms of pre-mRNAs/hnRNAs transcribed by RNA polymerase II. hnRNPs involve in a large number of cellular processes, including chromatin remodelling, transcription regulation, RNP assembly and stabilization, RNA export, virus replication, histone-like nucleoid structuring, and even intracellular immunity. Dysregulation of stress proteins is associated with many human diseases including human cancer, cardiovascular diseases, neurodegenerative diseases (e.g., Parkinson’s diseases, Alzheimer disease), stroke and infectious diseases. In this review, we summarized the biologic function of stress proteins, and current progress on their mechanisms related to virus reproduction and diseases caused by virus infections. As SPs also attract a great interest as potential antiviral targets (e.g., COVID-19), we also discuss the present progress and challenges in this area of HSP-based drug development, as well as with compounds already under clinical evaluation. Nature Publishing Group UK 2020-07-13 /pmc/articles/PMC7356129/ /pubmed/32661235 http://dx.doi.org/10.1038/s41392-020-00233-4 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Review Article Wan, Qianya Song, Dan Li, Huangcan He, Ming-liang Stress proteins: the biological functions in virus infection, present and challenges for target-based antiviral drug development |
title | Stress proteins: the biological functions in virus infection, present and challenges for target-based antiviral drug development |
title_full | Stress proteins: the biological functions in virus infection, present and challenges for target-based antiviral drug development |
title_fullStr | Stress proteins: the biological functions in virus infection, present and challenges for target-based antiviral drug development |
title_full_unstemmed | Stress proteins: the biological functions in virus infection, present and challenges for target-based antiviral drug development |
title_short | Stress proteins: the biological functions in virus infection, present and challenges for target-based antiviral drug development |
title_sort | stress proteins: the biological functions in virus infection, present and challenges for target-based antiviral drug development |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356129/ https://www.ncbi.nlm.nih.gov/pubmed/32661235 http://dx.doi.org/10.1038/s41392-020-00233-4 |
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