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Neurological manifestations of COVID-19: a systematic review
INTRODUCTION: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the global spread of coronavirus disease (COVID-19). Our understanding of the impact this virus has on the nervous system is limited. Our review aims to inform and improve decision-making among the physicia...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356133/ https://www.ncbi.nlm.nih.gov/pubmed/32660520 http://dx.doi.org/10.1186/s13054-020-03121-z |
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author | Nepal, Gaurav Rehrig, Jessica Holly Shrestha, Gentle Sunder Shing, Yow Ka Yadav, Jayant Kumar Ojha, Rajeev Pokhrel, Gaurab Tu, Zhi Lan Huang, Dong Ya |
author_facet | Nepal, Gaurav Rehrig, Jessica Holly Shrestha, Gentle Sunder Shing, Yow Ka Yadav, Jayant Kumar Ojha, Rajeev Pokhrel, Gaurab Tu, Zhi Lan Huang, Dong Ya |
author_sort | Nepal, Gaurav |
collection | PubMed |
description | INTRODUCTION: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the global spread of coronavirus disease (COVID-19). Our understanding of the impact this virus has on the nervous system is limited. Our review aims to inform and improve decision-making among the physicians treating COVID-19 by presenting a systematic analysis of the neurological manifestations experienced within these patients. METHODS: Any study, released prior to May 20, 2020, that reported neurological manifestations in patients infected by SARS-CoV-2 was systematically reviewed using the PRISMA (Preferred Reporting Items for Systemic review and Meta-Analysis) statement. RESULTS: Our systematic review included data from 37 articles: twelve retrospective studies, two prospective studies, and the rest case reports/series. The most commonly reported neurological manifestations of COVID-19 were myalgia, headache, altered sensorium, hyposmia, and hypogeusia. Uncommonly, COVID-19 can also present with central nervous system manifestations such as ischemic stroke, intracerebral hemorrhage, encephalo-myelitis, and acute myelitis, peripheral nervous manifestations such as Guillain-Barré syndrome and Bell’s palsy, and skeletal muscle manifestations such as rhabdomyolysis. CONCLUSION: While COVID-19 typically presents as a self-limiting respiratory disease, it has been reported in up to 20% of patients to progress to severe illness with multi-organ involvement. The neurological manifestations of COVID-19 are not uncommon, but our study found most resolve with treatment of the underlying infection. Although the timeliness of this review engages current challenges posed by the COVID-19 pandemic, readers must not ignore the limitations and biases intrinsic to an early investigation. |
format | Online Article Text |
id | pubmed-7356133 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-73561332020-07-13 Neurological manifestations of COVID-19: a systematic review Nepal, Gaurav Rehrig, Jessica Holly Shrestha, Gentle Sunder Shing, Yow Ka Yadav, Jayant Kumar Ojha, Rajeev Pokhrel, Gaurab Tu, Zhi Lan Huang, Dong Ya Crit Care Research INTRODUCTION: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the global spread of coronavirus disease (COVID-19). Our understanding of the impact this virus has on the nervous system is limited. Our review aims to inform and improve decision-making among the physicians treating COVID-19 by presenting a systematic analysis of the neurological manifestations experienced within these patients. METHODS: Any study, released prior to May 20, 2020, that reported neurological manifestations in patients infected by SARS-CoV-2 was systematically reviewed using the PRISMA (Preferred Reporting Items for Systemic review and Meta-Analysis) statement. RESULTS: Our systematic review included data from 37 articles: twelve retrospective studies, two prospective studies, and the rest case reports/series. The most commonly reported neurological manifestations of COVID-19 were myalgia, headache, altered sensorium, hyposmia, and hypogeusia. Uncommonly, COVID-19 can also present with central nervous system manifestations such as ischemic stroke, intracerebral hemorrhage, encephalo-myelitis, and acute myelitis, peripheral nervous manifestations such as Guillain-Barré syndrome and Bell’s palsy, and skeletal muscle manifestations such as rhabdomyolysis. CONCLUSION: While COVID-19 typically presents as a self-limiting respiratory disease, it has been reported in up to 20% of patients to progress to severe illness with multi-organ involvement. The neurological manifestations of COVID-19 are not uncommon, but our study found most resolve with treatment of the underlying infection. Although the timeliness of this review engages current challenges posed by the COVID-19 pandemic, readers must not ignore the limitations and biases intrinsic to an early investigation. BioMed Central 2020-07-13 /pmc/articles/PMC7356133/ /pubmed/32660520 http://dx.doi.org/10.1186/s13054-020-03121-z Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Nepal, Gaurav Rehrig, Jessica Holly Shrestha, Gentle Sunder Shing, Yow Ka Yadav, Jayant Kumar Ojha, Rajeev Pokhrel, Gaurab Tu, Zhi Lan Huang, Dong Ya Neurological manifestations of COVID-19: a systematic review |
title | Neurological manifestations of COVID-19: a systematic review |
title_full | Neurological manifestations of COVID-19: a systematic review |
title_fullStr | Neurological manifestations of COVID-19: a systematic review |
title_full_unstemmed | Neurological manifestations of COVID-19: a systematic review |
title_short | Neurological manifestations of COVID-19: a systematic review |
title_sort | neurological manifestations of covid-19: a systematic review |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356133/ https://www.ncbi.nlm.nih.gov/pubmed/32660520 http://dx.doi.org/10.1186/s13054-020-03121-z |
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