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Exposure Assessment of Cadmium in Female Farmers in Cadmium-Polluted Areas in Northern Japan

Akita prefecture is located in the northern part of Japan and has many cadmium-polluted areas. We herein performed an exposure assessment of cadmium in 712 and 432 female farmers in two adjacent cadmium-polluted areas (A and B, respectively), who underwent local health examinations from 2001–2004. W...

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Autores principales: Horiguchi, Hyogo, Oguma, Etsuko, Sasaki, Satoshi, Miyamoto, Kayoko, Hosoi, Yoko, Ono, Akira, Kayama, Fujio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356160/
https://www.ncbi.nlm.nih.gov/pubmed/32560341
http://dx.doi.org/10.3390/toxics8020044
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author Horiguchi, Hyogo
Oguma, Etsuko
Sasaki, Satoshi
Miyamoto, Kayoko
Hosoi, Yoko
Ono, Akira
Kayama, Fujio
author_facet Horiguchi, Hyogo
Oguma, Etsuko
Sasaki, Satoshi
Miyamoto, Kayoko
Hosoi, Yoko
Ono, Akira
Kayama, Fujio
author_sort Horiguchi, Hyogo
collection PubMed
description Akita prefecture is located in the northern part of Japan and has many cadmium-polluted areas. We herein performed an exposure assessment of cadmium in 712 and 432 female farmers in two adjacent cadmium-polluted areas (A and B, respectively), who underwent local health examinations from 2001–2004. We measured cadmium concentrations in 100 food items collected from local markets in 2003. We then multiplied the intake of each food item by its cadmium concentration in each subject to assess cadmium intake from food and summed cadmium intake from all food items to obtain the total cadmium intake. Median cadmium intake levels in areas A and B were 55.7 and 47.8 µg/day, respectively, which were both higher than that of the general population and were attributed to local agricultural products, particularly rice. We also calculated weekly cadmium intake per body weight and compared it to the previous provisional tolerable weekly intake reported by the Joint FAO (Food and Agriculture Organization)/WHO (World Health Organization) expert committee on food additives or current tolerable weekly intake in Japan of 7 µg/kg BW/week. Medians in areas A and B were 7.2 and 6.0 µg/kg BW/week, respectively. Similar estimated values were also obtained by the Monte Carlo simulation. These results demonstrated that the cadmium exposure levels among the farmers were high enough to be approximately the tolerable weekly intake.
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spelling pubmed-73561602020-07-31 Exposure Assessment of Cadmium in Female Farmers in Cadmium-Polluted Areas in Northern Japan Horiguchi, Hyogo Oguma, Etsuko Sasaki, Satoshi Miyamoto, Kayoko Hosoi, Yoko Ono, Akira Kayama, Fujio Toxics Article Akita prefecture is located in the northern part of Japan and has many cadmium-polluted areas. We herein performed an exposure assessment of cadmium in 712 and 432 female farmers in two adjacent cadmium-polluted areas (A and B, respectively), who underwent local health examinations from 2001–2004. We measured cadmium concentrations in 100 food items collected from local markets in 2003. We then multiplied the intake of each food item by its cadmium concentration in each subject to assess cadmium intake from food and summed cadmium intake from all food items to obtain the total cadmium intake. Median cadmium intake levels in areas A and B were 55.7 and 47.8 µg/day, respectively, which were both higher than that of the general population and were attributed to local agricultural products, particularly rice. We also calculated weekly cadmium intake per body weight and compared it to the previous provisional tolerable weekly intake reported by the Joint FAO (Food and Agriculture Organization)/WHO (World Health Organization) expert committee on food additives or current tolerable weekly intake in Japan of 7 µg/kg BW/week. Medians in areas A and B were 7.2 and 6.0 µg/kg BW/week, respectively. Similar estimated values were also obtained by the Monte Carlo simulation. These results demonstrated that the cadmium exposure levels among the farmers were high enough to be approximately the tolerable weekly intake. MDPI 2020-06-17 /pmc/articles/PMC7356160/ /pubmed/32560341 http://dx.doi.org/10.3390/toxics8020044 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Horiguchi, Hyogo
Oguma, Etsuko
Sasaki, Satoshi
Miyamoto, Kayoko
Hosoi, Yoko
Ono, Akira
Kayama, Fujio
Exposure Assessment of Cadmium in Female Farmers in Cadmium-Polluted Areas in Northern Japan
title Exposure Assessment of Cadmium in Female Farmers in Cadmium-Polluted Areas in Northern Japan
title_full Exposure Assessment of Cadmium in Female Farmers in Cadmium-Polluted Areas in Northern Japan
title_fullStr Exposure Assessment of Cadmium in Female Farmers in Cadmium-Polluted Areas in Northern Japan
title_full_unstemmed Exposure Assessment of Cadmium in Female Farmers in Cadmium-Polluted Areas in Northern Japan
title_short Exposure Assessment of Cadmium in Female Farmers in Cadmium-Polluted Areas in Northern Japan
title_sort exposure assessment of cadmium in female farmers in cadmium-polluted areas in northern japan
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356160/
https://www.ncbi.nlm.nih.gov/pubmed/32560341
http://dx.doi.org/10.3390/toxics8020044
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