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Effects of Decomplexation Rates on Ternary Gene Complex Transfection with α-Poly(l-Lysine) or ε-Poly(l-Lysine) as a Decomplexation Controller in An Easy-To-Transfect Cell or A Hard-To-Transfect Cell

The tight binding of pDNA with a cationic polymer is the crucial requirement that prevents DNA degradation from undesired DNase attack to safely deliver the pDNA to its target site. However, cationic polymer-mediated strong gene holding limits pDNA dissociation from the gene complex, resulting in a...

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Detalles Bibliográficos
Autores principales:	Kim, Kyoungnam, Ryu, Kitae, Cho, Hana, Shim, Min Suk, Cho, Yong-Yeon, Lee, Joo Young, Lee, Hye Suk, Kang, Han Chang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356167/ https://www.ncbi.nlm.nih.gov/pubmed/32481637 http://dx.doi.org/10.3390/pharmaceutics12060490

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