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Milk-Derived Extracellular Vesicles in Inter-Organism, Cross-Species Communication and Drug Delivery
Milk is considered as more than a source of nutrition for infants and is a vector involved in the transfer of bioactive compounds and cells. Milk contains abundant quantities of extracellular vesicles (EVs) that may originate from multiple cellular sources. These nanosized vesicles have been well ch...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356197/ https://www.ncbi.nlm.nih.gov/pubmed/32414045 http://dx.doi.org/10.3390/proteomes8020011 |
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author | Sanwlani, Rahul Fonseka, Pamali Chitti, Sai V. Mathivanan, Suresh |
author_facet | Sanwlani, Rahul Fonseka, Pamali Chitti, Sai V. Mathivanan, Suresh |
author_sort | Sanwlani, Rahul |
collection | PubMed |
description | Milk is considered as more than a source of nutrition for infants and is a vector involved in the transfer of bioactive compounds and cells. Milk contains abundant quantities of extracellular vesicles (EVs) that may originate from multiple cellular sources. These nanosized vesicles have been well characterized and are known to carry a diverse cargo of proteins, nucleic acids, lipids and other biomolecules. Milk-derived EVs have been demonstrated to survive harsh and degrading conditions in gut, taken up by various cell types, cross biological barriers and reach peripheral tissues. The cargo carried by these dietary EVs has been suggested to have a role in cell growth, development, immune modulation and regulation. Hence, there is considerable interest in understanding the role of milk-derived EVs in mediating inter-organismal and cross-species communication. Furthermore, various attributes such as it being a natural source, as well as its abundance, scalability, economic viability and lack of unwarranted immunologic reactions, has generated significant interest in deploying milk-derived EVs for clinical applications such as drug delivery and disease therapy. In this review, the role of milk-derived EVs in inter-organismal, cross-species communication and in drug delivery is discussed. |
format | Online Article Text |
id | pubmed-7356197 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-73561972020-07-31 Milk-Derived Extracellular Vesicles in Inter-Organism, Cross-Species Communication and Drug Delivery Sanwlani, Rahul Fonseka, Pamali Chitti, Sai V. Mathivanan, Suresh Proteomes Review Milk is considered as more than a source of nutrition for infants and is a vector involved in the transfer of bioactive compounds and cells. Milk contains abundant quantities of extracellular vesicles (EVs) that may originate from multiple cellular sources. These nanosized vesicles have been well characterized and are known to carry a diverse cargo of proteins, nucleic acids, lipids and other biomolecules. Milk-derived EVs have been demonstrated to survive harsh and degrading conditions in gut, taken up by various cell types, cross biological barriers and reach peripheral tissues. The cargo carried by these dietary EVs has been suggested to have a role in cell growth, development, immune modulation and regulation. Hence, there is considerable interest in understanding the role of milk-derived EVs in mediating inter-organismal and cross-species communication. Furthermore, various attributes such as it being a natural source, as well as its abundance, scalability, economic viability and lack of unwarranted immunologic reactions, has generated significant interest in deploying milk-derived EVs for clinical applications such as drug delivery and disease therapy. In this review, the role of milk-derived EVs in inter-organismal, cross-species communication and in drug delivery is discussed. MDPI 2020-05-13 /pmc/articles/PMC7356197/ /pubmed/32414045 http://dx.doi.org/10.3390/proteomes8020011 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Sanwlani, Rahul Fonseka, Pamali Chitti, Sai V. Mathivanan, Suresh Milk-Derived Extracellular Vesicles in Inter-Organism, Cross-Species Communication and Drug Delivery |
title | Milk-Derived Extracellular Vesicles in Inter-Organism, Cross-Species Communication and Drug Delivery |
title_full | Milk-Derived Extracellular Vesicles in Inter-Organism, Cross-Species Communication and Drug Delivery |
title_fullStr | Milk-Derived Extracellular Vesicles in Inter-Organism, Cross-Species Communication and Drug Delivery |
title_full_unstemmed | Milk-Derived Extracellular Vesicles in Inter-Organism, Cross-Species Communication and Drug Delivery |
title_short | Milk-Derived Extracellular Vesicles in Inter-Organism, Cross-Species Communication and Drug Delivery |
title_sort | milk-derived extracellular vesicles in inter-organism, cross-species communication and drug delivery |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356197/ https://www.ncbi.nlm.nih.gov/pubmed/32414045 http://dx.doi.org/10.3390/proteomes8020011 |
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