Cargando…

Milk-Derived Extracellular Vesicles in Inter-Organism, Cross-Species Communication and Drug Delivery

Milk is considered as more than a source of nutrition for infants and is a vector involved in the transfer of bioactive compounds and cells. Milk contains abundant quantities of extracellular vesicles (EVs) that may originate from multiple cellular sources. These nanosized vesicles have been well ch...

Descripción completa

Detalles Bibliográficos
Autores principales: Sanwlani, Rahul, Fonseka, Pamali, Chitti, Sai V., Mathivanan, Suresh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356197/
https://www.ncbi.nlm.nih.gov/pubmed/32414045
http://dx.doi.org/10.3390/proteomes8020011
_version_ 1783558444785074176
author Sanwlani, Rahul
Fonseka, Pamali
Chitti, Sai V.
Mathivanan, Suresh
author_facet Sanwlani, Rahul
Fonseka, Pamali
Chitti, Sai V.
Mathivanan, Suresh
author_sort Sanwlani, Rahul
collection PubMed
description Milk is considered as more than a source of nutrition for infants and is a vector involved in the transfer of bioactive compounds and cells. Milk contains abundant quantities of extracellular vesicles (EVs) that may originate from multiple cellular sources. These nanosized vesicles have been well characterized and are known to carry a diverse cargo of proteins, nucleic acids, lipids and other biomolecules. Milk-derived EVs have been demonstrated to survive harsh and degrading conditions in gut, taken up by various cell types, cross biological barriers and reach peripheral tissues. The cargo carried by these dietary EVs has been suggested to have a role in cell growth, development, immune modulation and regulation. Hence, there is considerable interest in understanding the role of milk-derived EVs in mediating inter-organismal and cross-species communication. Furthermore, various attributes such as it being a natural source, as well as its abundance, scalability, economic viability and lack of unwarranted immunologic reactions, has generated significant interest in deploying milk-derived EVs for clinical applications such as drug delivery and disease therapy. In this review, the role of milk-derived EVs in inter-organismal, cross-species communication and in drug delivery is discussed.
format Online
Article
Text
id pubmed-7356197
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-73561972020-07-31 Milk-Derived Extracellular Vesicles in Inter-Organism, Cross-Species Communication and Drug Delivery Sanwlani, Rahul Fonseka, Pamali Chitti, Sai V. Mathivanan, Suresh Proteomes Review Milk is considered as more than a source of nutrition for infants and is a vector involved in the transfer of bioactive compounds and cells. Milk contains abundant quantities of extracellular vesicles (EVs) that may originate from multiple cellular sources. These nanosized vesicles have been well characterized and are known to carry a diverse cargo of proteins, nucleic acids, lipids and other biomolecules. Milk-derived EVs have been demonstrated to survive harsh and degrading conditions in gut, taken up by various cell types, cross biological barriers and reach peripheral tissues. The cargo carried by these dietary EVs has been suggested to have a role in cell growth, development, immune modulation and regulation. Hence, there is considerable interest in understanding the role of milk-derived EVs in mediating inter-organismal and cross-species communication. Furthermore, various attributes such as it being a natural source, as well as its abundance, scalability, economic viability and lack of unwarranted immunologic reactions, has generated significant interest in deploying milk-derived EVs for clinical applications such as drug delivery and disease therapy. In this review, the role of milk-derived EVs in inter-organismal, cross-species communication and in drug delivery is discussed. MDPI 2020-05-13 /pmc/articles/PMC7356197/ /pubmed/32414045 http://dx.doi.org/10.3390/proteomes8020011 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sanwlani, Rahul
Fonseka, Pamali
Chitti, Sai V.
Mathivanan, Suresh
Milk-Derived Extracellular Vesicles in Inter-Organism, Cross-Species Communication and Drug Delivery
title Milk-Derived Extracellular Vesicles in Inter-Organism, Cross-Species Communication and Drug Delivery
title_full Milk-Derived Extracellular Vesicles in Inter-Organism, Cross-Species Communication and Drug Delivery
title_fullStr Milk-Derived Extracellular Vesicles in Inter-Organism, Cross-Species Communication and Drug Delivery
title_full_unstemmed Milk-Derived Extracellular Vesicles in Inter-Organism, Cross-Species Communication and Drug Delivery
title_short Milk-Derived Extracellular Vesicles in Inter-Organism, Cross-Species Communication and Drug Delivery
title_sort milk-derived extracellular vesicles in inter-organism, cross-species communication and drug delivery
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356197/
https://www.ncbi.nlm.nih.gov/pubmed/32414045
http://dx.doi.org/10.3390/proteomes8020011
work_keys_str_mv AT sanwlanirahul milkderivedextracellularvesiclesininterorganismcrossspeciescommunicationanddrugdelivery
AT fonsekapamali milkderivedextracellularvesiclesininterorganismcrossspeciescommunicationanddrugdelivery
AT chittisaiv milkderivedextracellularvesiclesininterorganismcrossspeciescommunicationanddrugdelivery
AT mathivanansuresh milkderivedextracellularvesiclesininterorganismcrossspeciescommunicationanddrugdelivery