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Alvaxanthone, a Thymidylate Synthase Inhibitor with Nematocidal and Tumoricidal Activities
With the aim to identify novel inhibitors of parasitic nematode thymidylate synthase (TS), we screened in silico an in-house library of natural compounds, taking advantage of a model of nematode TS three-dimensional (3D) structure and choosing candidate compounds potentially capable of enzyme bindin...
Autores principales: | Maj, Piotr, Mori, Mattia, Sobich, Justyna, Markowicz, Joanna, Uram, Łukasz, Zieliński, Zbigniew, Quaglio, Deborah, Calcaterra, Andrea, Cau, Ylenia, Botta, Bruno, Rode, Wojciech |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356228/ https://www.ncbi.nlm.nih.gov/pubmed/32586022 http://dx.doi.org/10.3390/molecules25122894 |
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