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NHC-catalyzed enantioselective synthesis of β-trifluoromethyl-β-hydroxyamides

The N-heterocyclic carbene (NHC)-catalyzed formal [2 + 2] cycloaddition between α-aroyloxyaldehydes and trifluoroacetophenones, followed by ring opening with an amine or a reducing agent is described. The resulting β-trifluoromethyl-β-hydroxyamide and alcohol products are produced with reasonable di...

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Detalles Bibliográficos
Autores principales:	Davies, Alyn T, Greenhalgh, Mark D, Slawin, Alexandra M Z, Smith, Andrew D
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Beilstein-Institut 2020
Materias:	Letter
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356285/ https://www.ncbi.nlm.nih.gov/pubmed/32704323 http://dx.doi.org/10.3762/bjoc.16.129

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