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Hybrid Quinoline-Sulfonamide Complexes (M(2+)) Derivatives with Antimicrobial Activity

Two new series of hybrid quinoline-sulfonamide complexes (M(2+): Zn(2+), Cu(2+), Co(2+) and Cd(2+)) derivatives (QSC) were designed, synthesized and tested for their antimicrobial activity. The synthesis is straightforward and efficient, involving two steps: acylation of aminoquinoline followed by c...

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Autores principales: Diaconu, Dumitrela, Mangalagiu, Violeta, Amariucai-Mantu, Dorina, Antoci, Vasilichia, Giuroiu, Cristian Levente, Mangalagiu, Ionel I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356327/
https://www.ncbi.nlm.nih.gov/pubmed/32604828
http://dx.doi.org/10.3390/molecules25122946
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author Diaconu, Dumitrela
Mangalagiu, Violeta
Amariucai-Mantu, Dorina
Antoci, Vasilichia
Giuroiu, Cristian Levente
Mangalagiu, Ionel I.
author_facet Diaconu, Dumitrela
Mangalagiu, Violeta
Amariucai-Mantu, Dorina
Antoci, Vasilichia
Giuroiu, Cristian Levente
Mangalagiu, Ionel I.
author_sort Diaconu, Dumitrela
collection PubMed
description Two new series of hybrid quinoline-sulfonamide complexes (M(2+): Zn(2+), Cu(2+), Co(2+) and Cd(2+)) derivatives (QSC) were designed, synthesized and tested for their antimicrobial activity. The synthesis is straightforward and efficient, involving two steps: acylation of aminoquinoline followed by complexation with metal acetate (Cu(2+), Co(2+) and Cd(2+)) or chloride (Zn(2+)). The synthesized QSC compounds were characterized by FTIR and NMR spectroscopy and by X-ray diffraction on single crystal. The QSC compounds were preliminary screened for their antibacterial and antifungal activity and the obtained results are very promising. In this respect, the hybrid N-(quinolin-8-yl)-4-chloro-benzenesulfonamide cadmium (II), considered as leading structure for further studies, has an excellent antibacterial activity against Staphylococcus aureus ATCC25923 (with a diameters of inhibition zones of 21 mm and a minimum inhibitory concentration (MIC) of 19.04 × 10(−5) mg/mL), a very good antibacterial activity against Escherichia coli ATCC25922 (with a diameters of inhibition zones of 19 mm and a MIC of 609 × 10(−5) mg/mL), and again an excellent antifungal activity against Candida albicans ATCC10231 (with a diameters of inhibition zones of 25 mm and a MIC of 19.04 × 10(−5) mg/mL).
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spelling pubmed-73563272020-07-31 Hybrid Quinoline-Sulfonamide Complexes (M(2+)) Derivatives with Antimicrobial Activity Diaconu, Dumitrela Mangalagiu, Violeta Amariucai-Mantu, Dorina Antoci, Vasilichia Giuroiu, Cristian Levente Mangalagiu, Ionel I. Molecules Communication Two new series of hybrid quinoline-sulfonamide complexes (M(2+): Zn(2+), Cu(2+), Co(2+) and Cd(2+)) derivatives (QSC) were designed, synthesized and tested for their antimicrobial activity. The synthesis is straightforward and efficient, involving two steps: acylation of aminoquinoline followed by complexation with metal acetate (Cu(2+), Co(2+) and Cd(2+)) or chloride (Zn(2+)). The synthesized QSC compounds were characterized by FTIR and NMR spectroscopy and by X-ray diffraction on single crystal. The QSC compounds were preliminary screened for their antibacterial and antifungal activity and the obtained results are very promising. In this respect, the hybrid N-(quinolin-8-yl)-4-chloro-benzenesulfonamide cadmium (II), considered as leading structure for further studies, has an excellent antibacterial activity against Staphylococcus aureus ATCC25923 (with a diameters of inhibition zones of 21 mm and a minimum inhibitory concentration (MIC) of 19.04 × 10(−5) mg/mL), a very good antibacterial activity against Escherichia coli ATCC25922 (with a diameters of inhibition zones of 19 mm and a MIC of 609 × 10(−5) mg/mL), and again an excellent antifungal activity against Candida albicans ATCC10231 (with a diameters of inhibition zones of 25 mm and a MIC of 19.04 × 10(−5) mg/mL). MDPI 2020-06-26 /pmc/articles/PMC7356327/ /pubmed/32604828 http://dx.doi.org/10.3390/molecules25122946 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Diaconu, Dumitrela
Mangalagiu, Violeta
Amariucai-Mantu, Dorina
Antoci, Vasilichia
Giuroiu, Cristian Levente
Mangalagiu, Ionel I.
Hybrid Quinoline-Sulfonamide Complexes (M(2+)) Derivatives with Antimicrobial Activity
title Hybrid Quinoline-Sulfonamide Complexes (M(2+)) Derivatives with Antimicrobial Activity
title_full Hybrid Quinoline-Sulfonamide Complexes (M(2+)) Derivatives with Antimicrobial Activity
title_fullStr Hybrid Quinoline-Sulfonamide Complexes (M(2+)) Derivatives with Antimicrobial Activity
title_full_unstemmed Hybrid Quinoline-Sulfonamide Complexes (M(2+)) Derivatives with Antimicrobial Activity
title_short Hybrid Quinoline-Sulfonamide Complexes (M(2+)) Derivatives with Antimicrobial Activity
title_sort hybrid quinoline-sulfonamide complexes (m(2+)) derivatives with antimicrobial activity
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356327/
https://www.ncbi.nlm.nih.gov/pubmed/32604828
http://dx.doi.org/10.3390/molecules25122946
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