Design, Synthesis, and Biological Evaluation of 8-Mercapto-3,7-Dihydro-1H-Purine-2,6-Diones as Potent Inhibitors of SIRT1, SIRT2, SIRT3, and SIRT5

Sirtuins (SIRT1-7) are a family of NAD(+)-dependent deacetylases. They regulate many physiological processes and play important roles in inflammation, diabetes, cancers, and neurodegeneration diseases. Sirtuin inhibitors have potential applications in the treatment of neurodegenerative diseases and...

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Detalles Bibliográficos
Autores principales: Han, Haozhen, Li, Chunpu, Li, Man, Yang, Lisheng, Zhao, Sen, Wang, Zhifei, Liu, Hong, Liu, Dongxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356367/
https://www.ncbi.nlm.nih.gov/pubmed/32549218
http://dx.doi.org/10.3390/molecules25122755

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356367/
https://www.ncbi.nlm.nih.gov/pubmed/32549218
http://dx.doi.org/10.3390/molecules25122755

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