Cargando…

Evaluation of Symmetric Dimethylarginine (SDMA) in Dogs with Acute Pancreatitis

Symmetric dimethylarginine (SDMA) is considered an important biomarker of kidney dysfunction. The aims of the study were to evaluate SDMA in dogs with acute pancreatitis (AP) and its relationship with the presence of kidney injury and mortality. A cohort study including fifty-four dogs with AP diagn...

Descripción completa

Detalles Bibliográficos
Autores principales: Gori, Eleonora, Pierini, Alessio, Lippi, Ilaria, Meucci, Valentina, Perondi, Francesca, Marchetti, Veronica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356378/
https://www.ncbi.nlm.nih.gov/pubmed/32492828
http://dx.doi.org/10.3390/vetsci7020072
_version_ 1783558485302050816
author Gori, Eleonora
Pierini, Alessio
Lippi, Ilaria
Meucci, Valentina
Perondi, Francesca
Marchetti, Veronica
author_facet Gori, Eleonora
Pierini, Alessio
Lippi, Ilaria
Meucci, Valentina
Perondi, Francesca
Marchetti, Veronica
author_sort Gori, Eleonora
collection PubMed
description Symmetric dimethylarginine (SDMA) is considered an important biomarker of kidney dysfunction. The aims of the study were to evaluate SDMA in dogs with acute pancreatitis (AP) and its relationship with the presence of kidney injury and mortality. A cohort study including fifty-four dogs with AP diagnosed using compatible clinical and laboratory parameters, abnormal SNAP cPL and compatible abdominal ultrasound within 48 h from admission, was conducted. Dogs with history of renal and/or urinary diseases were excluded, along with dogs exposed to nephrotoxic drugs. Serum urea and creatinine and urinary output (UO) were recorded. Acute kidney injury (AKI) was diagnosed and graded using International Renal Interest Society (IRIS) guidelines. SDMA was measured using high performance liquid chromatography. Fifty-four dogs were included and divided in non-AKI (n = 37) and AKI dogs (n = 17). Twenty-three dogs (14 non-AKI) had SDMA > 15 μg/dL. Median SDMA was higher in AKI dogs than non-AKI dogs (25.7 vs. 13.93 μg/dL; p = 0.03). Dogs with normal creatinine (AP and AKI 1 dogs) had SDMA above reference range in 38% and 33% of cases, respectively. In AKI dogs, SDMA and creatinine were positively correlated (p = 0.006 r = 0.7). SDMA was not significantly different between survivors and non-survivors. Although further studies are warranted, SDMA may be a useful tool in canine AP, as a high SDMA may be related to subclinical kidney impairment.
format Online
Article
Text
id pubmed-7356378
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-73563782020-07-30 Evaluation of Symmetric Dimethylarginine (SDMA) in Dogs with Acute Pancreatitis Gori, Eleonora Pierini, Alessio Lippi, Ilaria Meucci, Valentina Perondi, Francesca Marchetti, Veronica Vet Sci Article Symmetric dimethylarginine (SDMA) is considered an important biomarker of kidney dysfunction. The aims of the study were to evaluate SDMA in dogs with acute pancreatitis (AP) and its relationship with the presence of kidney injury and mortality. A cohort study including fifty-four dogs with AP diagnosed using compatible clinical and laboratory parameters, abnormal SNAP cPL and compatible abdominal ultrasound within 48 h from admission, was conducted. Dogs with history of renal and/or urinary diseases were excluded, along with dogs exposed to nephrotoxic drugs. Serum urea and creatinine and urinary output (UO) were recorded. Acute kidney injury (AKI) was diagnosed and graded using International Renal Interest Society (IRIS) guidelines. SDMA was measured using high performance liquid chromatography. Fifty-four dogs were included and divided in non-AKI (n = 37) and AKI dogs (n = 17). Twenty-three dogs (14 non-AKI) had SDMA > 15 μg/dL. Median SDMA was higher in AKI dogs than non-AKI dogs (25.7 vs. 13.93 μg/dL; p = 0.03). Dogs with normal creatinine (AP and AKI 1 dogs) had SDMA above reference range in 38% and 33% of cases, respectively. In AKI dogs, SDMA and creatinine were positively correlated (p = 0.006 r = 0.7). SDMA was not significantly different between survivors and non-survivors. Although further studies are warranted, SDMA may be a useful tool in canine AP, as a high SDMA may be related to subclinical kidney impairment. MDPI 2020-06-01 /pmc/articles/PMC7356378/ /pubmed/32492828 http://dx.doi.org/10.3390/vetsci7020072 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gori, Eleonora
Pierini, Alessio
Lippi, Ilaria
Meucci, Valentina
Perondi, Francesca
Marchetti, Veronica
Evaluation of Symmetric Dimethylarginine (SDMA) in Dogs with Acute Pancreatitis
title Evaluation of Symmetric Dimethylarginine (SDMA) in Dogs with Acute Pancreatitis
title_full Evaluation of Symmetric Dimethylarginine (SDMA) in Dogs with Acute Pancreatitis
title_fullStr Evaluation of Symmetric Dimethylarginine (SDMA) in Dogs with Acute Pancreatitis
title_full_unstemmed Evaluation of Symmetric Dimethylarginine (SDMA) in Dogs with Acute Pancreatitis
title_short Evaluation of Symmetric Dimethylarginine (SDMA) in Dogs with Acute Pancreatitis
title_sort evaluation of symmetric dimethylarginine (sdma) in dogs with acute pancreatitis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356378/
https://www.ncbi.nlm.nih.gov/pubmed/32492828
http://dx.doi.org/10.3390/vetsci7020072
work_keys_str_mv AT gorieleonora evaluationofsymmetricdimethylargininesdmaindogswithacutepancreatitis
AT pierinialessio evaluationofsymmetricdimethylargininesdmaindogswithacutepancreatitis
AT lippiilaria evaluationofsymmetricdimethylargininesdmaindogswithacutepancreatitis
AT meuccivalentina evaluationofsymmetricdimethylargininesdmaindogswithacutepancreatitis
AT perondifrancesca evaluationofsymmetricdimethylargininesdmaindogswithacutepancreatitis
AT marchettiveronica evaluationofsymmetricdimethylargininesdmaindogswithacutepancreatitis