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The Spectrum of Interstitial Lung Disease Associated with Autoimmune Diseases: Data of a 3.6-Year Prospective Study from a Referral Center of Interstitial Lung Disease and Lung Transplantation †
Interstitial lung disease (ILD) may occur in patients with a rheumatic autoimmune disease (AD), increasing their risk of morbidity and mortality. However, little is known about the prevalence of AD in patients diagnosed with an ILD. In this prospective study, we determined the spectrum of ILD associ...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356573/ https://www.ncbi.nlm.nih.gov/pubmed/32466389 http://dx.doi.org/10.3390/jcm9061606 |
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author | Atienza-Mateo, Belén Remuzgo-Martínez, Sara Mora Cuesta, Víctor Manuel Iturbe-Fernández, David Fernández-Rozas, Sonia Prieto-Peña, Diana Calderón-Goercke, Mónica Corrales, Alfonso Blanco Rodríguez, Gerardo Gómez-Román, José Javier González-Gay, Miguel Ángel Cifrián, José Manuel |
author_facet | Atienza-Mateo, Belén Remuzgo-Martínez, Sara Mora Cuesta, Víctor Manuel Iturbe-Fernández, David Fernández-Rozas, Sonia Prieto-Peña, Diana Calderón-Goercke, Mónica Corrales, Alfonso Blanco Rodríguez, Gerardo Gómez-Román, José Javier González-Gay, Miguel Ángel Cifrián, José Manuel |
author_sort | Atienza-Mateo, Belén |
collection | PubMed |
description | Interstitial lung disease (ILD) may occur in patients with a rheumatic autoimmune disease (AD), increasing their risk of morbidity and mortality. However, little is known about the prevalence of AD in patients diagnosed with an ILD. In this prospective study, we determined the spectrum of ILD associated with AD (AD-ILD) among patients sent for assessment to a single clinic of ILD and lung transplantation from a referral center between May 2016 and December 2019. ILD diagnosis was made by pneumologists based on clinical and radiological findings and pulmonary function test abnormalities. All patients with ILD were also assessed by experienced rheumatologists. During the period of assessment, 338 patients were diagnosed with ILD. Among them, 32.8% fulfilled definitions for an AD. Most cases with AD-ILD had a diagnosis of rheumatoid arthritis (27.0%), systemic sclerosis (26.1%) or anti-synthetase syndrome (17.1%). Interestingly, 18% of the patients with AD-ILD were diagnosed as having an interstitial pneumonia with autoimmune features. Antinuclear antibodies and non-specific interstitial pneumonia were the most frequent positive autoantibodies and radiological pattern found in AD-ILD patients, respectively. In conclusion, our study indicates that a high number of ILD patients have a related AD. Consequently, close collaboration among rheumatologists and pneumologists is needed. |
format | Online Article Text |
id | pubmed-7356573 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-73565732020-07-30 The Spectrum of Interstitial Lung Disease Associated with Autoimmune Diseases: Data of a 3.6-Year Prospective Study from a Referral Center of Interstitial Lung Disease and Lung Transplantation † Atienza-Mateo, Belén Remuzgo-Martínez, Sara Mora Cuesta, Víctor Manuel Iturbe-Fernández, David Fernández-Rozas, Sonia Prieto-Peña, Diana Calderón-Goercke, Mónica Corrales, Alfonso Blanco Rodríguez, Gerardo Gómez-Román, José Javier González-Gay, Miguel Ángel Cifrián, José Manuel J Clin Med Article Interstitial lung disease (ILD) may occur in patients with a rheumatic autoimmune disease (AD), increasing their risk of morbidity and mortality. However, little is known about the prevalence of AD in patients diagnosed with an ILD. In this prospective study, we determined the spectrum of ILD associated with AD (AD-ILD) among patients sent for assessment to a single clinic of ILD and lung transplantation from a referral center between May 2016 and December 2019. ILD diagnosis was made by pneumologists based on clinical and radiological findings and pulmonary function test abnormalities. All patients with ILD were also assessed by experienced rheumatologists. During the period of assessment, 338 patients were diagnosed with ILD. Among them, 32.8% fulfilled definitions for an AD. Most cases with AD-ILD had a diagnosis of rheumatoid arthritis (27.0%), systemic sclerosis (26.1%) or anti-synthetase syndrome (17.1%). Interestingly, 18% of the patients with AD-ILD were diagnosed as having an interstitial pneumonia with autoimmune features. Antinuclear antibodies and non-specific interstitial pneumonia were the most frequent positive autoantibodies and radiological pattern found in AD-ILD patients, respectively. In conclusion, our study indicates that a high number of ILD patients have a related AD. Consequently, close collaboration among rheumatologists and pneumologists is needed. MDPI 2020-05-26 /pmc/articles/PMC7356573/ /pubmed/32466389 http://dx.doi.org/10.3390/jcm9061606 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Atienza-Mateo, Belén Remuzgo-Martínez, Sara Mora Cuesta, Víctor Manuel Iturbe-Fernández, David Fernández-Rozas, Sonia Prieto-Peña, Diana Calderón-Goercke, Mónica Corrales, Alfonso Blanco Rodríguez, Gerardo Gómez-Román, José Javier González-Gay, Miguel Ángel Cifrián, José Manuel The Spectrum of Interstitial Lung Disease Associated with Autoimmune Diseases: Data of a 3.6-Year Prospective Study from a Referral Center of Interstitial Lung Disease and Lung Transplantation † |
title | The Spectrum of Interstitial Lung Disease Associated with Autoimmune Diseases: Data of a 3.6-Year Prospective Study from a Referral Center of Interstitial Lung Disease and Lung Transplantation † |
title_full | The Spectrum of Interstitial Lung Disease Associated with Autoimmune Diseases: Data of a 3.6-Year Prospective Study from a Referral Center of Interstitial Lung Disease and Lung Transplantation † |
title_fullStr | The Spectrum of Interstitial Lung Disease Associated with Autoimmune Diseases: Data of a 3.6-Year Prospective Study from a Referral Center of Interstitial Lung Disease and Lung Transplantation † |
title_full_unstemmed | The Spectrum of Interstitial Lung Disease Associated with Autoimmune Diseases: Data of a 3.6-Year Prospective Study from a Referral Center of Interstitial Lung Disease and Lung Transplantation † |
title_short | The Spectrum of Interstitial Lung Disease Associated with Autoimmune Diseases: Data of a 3.6-Year Prospective Study from a Referral Center of Interstitial Lung Disease and Lung Transplantation † |
title_sort | spectrum of interstitial lung disease associated with autoimmune diseases: data of a 3.6-year prospective study from a referral center of interstitial lung disease and lung transplantation † |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356573/ https://www.ncbi.nlm.nih.gov/pubmed/32466389 http://dx.doi.org/10.3390/jcm9061606 |
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