Identification of Human Leukotriene A4 Hydrolase Inhibitors Using Structure-Based Pharmacophore Modeling and Molecular Docking

Leukotriene B4 (LTB4) is a potent, proinflammatory lipid mediator implicated in the pathologies of an array of inflammatory diseases and cancer. The biosynthesis of LTB4 is regulated by the leukotriene A4 hydrolase (LTA(4)H). Compounds capable of limiting the formation of LTB4, through selective inh...

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Detalles Bibliográficos
Autores principales: Audat, Suaad A., Al-Shar’i, Nizar A., Al-Oudat, Buthina A., Bryant-Friedrich, Amanda, Bedi, Mel F., Zayed, Aref L., Al-Balas, Qosay A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356593/
https://www.ncbi.nlm.nih.gov/pubmed/32580506
http://dx.doi.org/10.3390/molecules25122871

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356593/
https://www.ncbi.nlm.nih.gov/pubmed/32580506
http://dx.doi.org/10.3390/molecules25122871

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