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Role of Advanced Glycation End Products on Aortic Calcification in Patients with Type 2 Diabetes Mellitus

The aim of this study was to evaluate the relationship between serum levels of advanced glycation end products (AGEs) and abdominal aortic calcification (AAC) in patients with type 2 diabetes mellitus (DM2). This was a prospective cross-sectional study. One-hundred and four consecutive patients with...

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Autores principales: Sanchis, Pilar, Rivera, Rosmeri, Fortuny, Regina, Río, Carlos, Mas-Gelabert, Miguel, Gonzalez-Freire, Marta, Grases, Felix, Masmiquel, Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356630/
https://www.ncbi.nlm.nih.gov/pubmed/32516928
http://dx.doi.org/10.3390/jcm9061751
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author Sanchis, Pilar
Rivera, Rosmeri
Fortuny, Regina
Río, Carlos
Mas-Gelabert, Miguel
Gonzalez-Freire, Marta
Grases, Felix
Masmiquel, Luis
author_facet Sanchis, Pilar
Rivera, Rosmeri
Fortuny, Regina
Río, Carlos
Mas-Gelabert, Miguel
Gonzalez-Freire, Marta
Grases, Felix
Masmiquel, Luis
author_sort Sanchis, Pilar
collection PubMed
description The aim of this study was to evaluate the relationship between serum levels of advanced glycation end products (AGEs) and abdominal aortic calcification (AAC) in patients with type 2 diabetes mellitus (DM2). This was a prospective cross-sectional study. One-hundred and four consecutive patients with DM2 were given lateral lumbar X-rays in order to quantify abdominal aortic calcification (AAC). Circulating levels of AGEs and classical cardiovascular risk factors were determined. Clinical history was also registered. Patients with higher AGEs values had higher grades of aortic calcification and higher numbers of diabetic-related complications. Multivariate logistic regression analysis showed that being older, male and having high levels of AGEs and triglycerides were the independent risk factors associated to moderate-severe AAC when compared to no-mild AAC. Our results suggest that AGEs plays a role in the pathogenesis of aortic calcifications. In addition, the measurement of AGEs levels may be useful for assessing the severity of AAC in the setting of diabetic complications.
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spelling pubmed-73566302020-07-22 Role of Advanced Glycation End Products on Aortic Calcification in Patients with Type 2 Diabetes Mellitus Sanchis, Pilar Rivera, Rosmeri Fortuny, Regina Río, Carlos Mas-Gelabert, Miguel Gonzalez-Freire, Marta Grases, Felix Masmiquel, Luis J Clin Med Article The aim of this study was to evaluate the relationship between serum levels of advanced glycation end products (AGEs) and abdominal aortic calcification (AAC) in patients with type 2 diabetes mellitus (DM2). This was a prospective cross-sectional study. One-hundred and four consecutive patients with DM2 were given lateral lumbar X-rays in order to quantify abdominal aortic calcification (AAC). Circulating levels of AGEs and classical cardiovascular risk factors were determined. Clinical history was also registered. Patients with higher AGEs values had higher grades of aortic calcification and higher numbers of diabetic-related complications. Multivariate logistic regression analysis showed that being older, male and having high levels of AGEs and triglycerides were the independent risk factors associated to moderate-severe AAC when compared to no-mild AAC. Our results suggest that AGEs plays a role in the pathogenesis of aortic calcifications. In addition, the measurement of AGEs levels may be useful for assessing the severity of AAC in the setting of diabetic complications. MDPI 2020-06-05 /pmc/articles/PMC7356630/ /pubmed/32516928 http://dx.doi.org/10.3390/jcm9061751 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sanchis, Pilar
Rivera, Rosmeri
Fortuny, Regina
Río, Carlos
Mas-Gelabert, Miguel
Gonzalez-Freire, Marta
Grases, Felix
Masmiquel, Luis
Role of Advanced Glycation End Products on Aortic Calcification in Patients with Type 2 Diabetes Mellitus
title Role of Advanced Glycation End Products on Aortic Calcification in Patients with Type 2 Diabetes Mellitus
title_full Role of Advanced Glycation End Products on Aortic Calcification in Patients with Type 2 Diabetes Mellitus
title_fullStr Role of Advanced Glycation End Products on Aortic Calcification in Patients with Type 2 Diabetes Mellitus
title_full_unstemmed Role of Advanced Glycation End Products on Aortic Calcification in Patients with Type 2 Diabetes Mellitus
title_short Role of Advanced Glycation End Products on Aortic Calcification in Patients with Type 2 Diabetes Mellitus
title_sort role of advanced glycation end products on aortic calcification in patients with type 2 diabetes mellitus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356630/
https://www.ncbi.nlm.nih.gov/pubmed/32516928
http://dx.doi.org/10.3390/jcm9061751
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