Cargando…
Role of Advanced Glycation End Products on Aortic Calcification in Patients with Type 2 Diabetes Mellitus
The aim of this study was to evaluate the relationship between serum levels of advanced glycation end products (AGEs) and abdominal aortic calcification (AAC) in patients with type 2 diabetes mellitus (DM2). This was a prospective cross-sectional study. One-hundred and four consecutive patients with...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356630/ https://www.ncbi.nlm.nih.gov/pubmed/32516928 http://dx.doi.org/10.3390/jcm9061751 |
_version_ | 1783558533989531648 |
---|---|
author | Sanchis, Pilar Rivera, Rosmeri Fortuny, Regina Río, Carlos Mas-Gelabert, Miguel Gonzalez-Freire, Marta Grases, Felix Masmiquel, Luis |
author_facet | Sanchis, Pilar Rivera, Rosmeri Fortuny, Regina Río, Carlos Mas-Gelabert, Miguel Gonzalez-Freire, Marta Grases, Felix Masmiquel, Luis |
author_sort | Sanchis, Pilar |
collection | PubMed |
description | The aim of this study was to evaluate the relationship between serum levels of advanced glycation end products (AGEs) and abdominal aortic calcification (AAC) in patients with type 2 diabetes mellitus (DM2). This was a prospective cross-sectional study. One-hundred and four consecutive patients with DM2 were given lateral lumbar X-rays in order to quantify abdominal aortic calcification (AAC). Circulating levels of AGEs and classical cardiovascular risk factors were determined. Clinical history was also registered. Patients with higher AGEs values had higher grades of aortic calcification and higher numbers of diabetic-related complications. Multivariate logistic regression analysis showed that being older, male and having high levels of AGEs and triglycerides were the independent risk factors associated to moderate-severe AAC when compared to no-mild AAC. Our results suggest that AGEs plays a role in the pathogenesis of aortic calcifications. In addition, the measurement of AGEs levels may be useful for assessing the severity of AAC in the setting of diabetic complications. |
format | Online Article Text |
id | pubmed-7356630 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-73566302020-07-22 Role of Advanced Glycation End Products on Aortic Calcification in Patients with Type 2 Diabetes Mellitus Sanchis, Pilar Rivera, Rosmeri Fortuny, Regina Río, Carlos Mas-Gelabert, Miguel Gonzalez-Freire, Marta Grases, Felix Masmiquel, Luis J Clin Med Article The aim of this study was to evaluate the relationship between serum levels of advanced glycation end products (AGEs) and abdominal aortic calcification (AAC) in patients with type 2 diabetes mellitus (DM2). This was a prospective cross-sectional study. One-hundred and four consecutive patients with DM2 were given lateral lumbar X-rays in order to quantify abdominal aortic calcification (AAC). Circulating levels of AGEs and classical cardiovascular risk factors were determined. Clinical history was also registered. Patients with higher AGEs values had higher grades of aortic calcification and higher numbers of diabetic-related complications. Multivariate logistic regression analysis showed that being older, male and having high levels of AGEs and triglycerides were the independent risk factors associated to moderate-severe AAC when compared to no-mild AAC. Our results suggest that AGEs plays a role in the pathogenesis of aortic calcifications. In addition, the measurement of AGEs levels may be useful for assessing the severity of AAC in the setting of diabetic complications. MDPI 2020-06-05 /pmc/articles/PMC7356630/ /pubmed/32516928 http://dx.doi.org/10.3390/jcm9061751 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sanchis, Pilar Rivera, Rosmeri Fortuny, Regina Río, Carlos Mas-Gelabert, Miguel Gonzalez-Freire, Marta Grases, Felix Masmiquel, Luis Role of Advanced Glycation End Products on Aortic Calcification in Patients with Type 2 Diabetes Mellitus |
title | Role of Advanced Glycation End Products on Aortic Calcification in Patients with Type 2 Diabetes Mellitus |
title_full | Role of Advanced Glycation End Products on Aortic Calcification in Patients with Type 2 Diabetes Mellitus |
title_fullStr | Role of Advanced Glycation End Products on Aortic Calcification in Patients with Type 2 Diabetes Mellitus |
title_full_unstemmed | Role of Advanced Glycation End Products on Aortic Calcification in Patients with Type 2 Diabetes Mellitus |
title_short | Role of Advanced Glycation End Products on Aortic Calcification in Patients with Type 2 Diabetes Mellitus |
title_sort | role of advanced glycation end products on aortic calcification in patients with type 2 diabetes mellitus |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356630/ https://www.ncbi.nlm.nih.gov/pubmed/32516928 http://dx.doi.org/10.3390/jcm9061751 |
work_keys_str_mv | AT sanchispilar roleofadvancedglycationendproductsonaorticcalcificationinpatientswithtype2diabetesmellitus AT riverarosmeri roleofadvancedglycationendproductsonaorticcalcificationinpatientswithtype2diabetesmellitus AT fortunyregina roleofadvancedglycationendproductsonaorticcalcificationinpatientswithtype2diabetesmellitus AT riocarlos roleofadvancedglycationendproductsonaorticcalcificationinpatientswithtype2diabetesmellitus AT masgelabertmiguel roleofadvancedglycationendproductsonaorticcalcificationinpatientswithtype2diabetesmellitus AT gonzalezfreiremarta roleofadvancedglycationendproductsonaorticcalcificationinpatientswithtype2diabetesmellitus AT grasesfelix roleofadvancedglycationendproductsonaorticcalcificationinpatientswithtype2diabetesmellitus AT masmiquelluis roleofadvancedglycationendproductsonaorticcalcificationinpatientswithtype2diabetesmellitus |