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Implications of the Adiponectin System in Non-Small Cell Lung Cancer Patients: A Case-Control Study

Alterations of adipose tissue occurring in obesity have been recognized as a major risk factor for several cancers. The relationship between adipose tissue and lung cancer, which is the main cancer-related cause of death worldwide, still requires investigation. Perturbations in the adipokine system...

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Autores principales: Nigro, Ersilia, Perrotta, Fabio, Monaco, Maria Ludovica, Polito, Rita, Pafundi, Pia Clara, Matera, Maria Gabriella, Daniele, Aurora, Bianco, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356727/
https://www.ncbi.nlm.nih.gov/pubmed/32570854
http://dx.doi.org/10.3390/biom10060926
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author Nigro, Ersilia
Perrotta, Fabio
Monaco, Maria Ludovica
Polito, Rita
Pafundi, Pia Clara
Matera, Maria Gabriella
Daniele, Aurora
Bianco, Andrea
author_facet Nigro, Ersilia
Perrotta, Fabio
Monaco, Maria Ludovica
Polito, Rita
Pafundi, Pia Clara
Matera, Maria Gabriella
Daniele, Aurora
Bianco, Andrea
author_sort Nigro, Ersilia
collection PubMed
description Alterations of adipose tissue occurring in obesity have been recognized as a major risk factor for several cancers. The relationship between adipose tissue and lung cancer, which is the main cancer-related cause of death worldwide, still requires investigation. Perturbations in the adipokine system are likely to interfere with inter-organ crosstalk in lung cancer, which may influence the lung tumor microenvironment. Adiponectin (Acrp30) expression is deregulated in several cancer types. Acrp30 circulates as oligomers with a Low (LMW), Medium (MMW), and High Molecular Weight (HMW), with the latter mediating the main biological effects. Acrp30 acts through AdipoR1 and AdipoR2 receptors. T-cadherin has been described as a non-signaling receptor. This study’s aim was to investigate the regulation of serum Acrp30 and its receptors in sample tissue from non-small cell lung cancer (NSCLC) patients. We recruited 72 NSCLC patients and 60 healthy controls, whom we evaluated in terms of their Acpr30 levels and oligomeric profile. In addition, the expression of AdipoRs in tissues from lung cancer specimens was also measured and compared to coupled healthy lung samples. Our findings show a significant reduction of total Acrp30 levels in NSCLC patients compared to normal subjects, with a specific down-regulation of HMW oligomers. Acrp30 expression was lower in lung adenocarcinoma than other subtypes, regardless of other factors. A significantly higher expression of AdipoR1 was observed, while no differences in R2 and a lower expression of T-cadherin were found in lung cancer specimens compared to normal healthy lung tissues. Involvement of the Acrp30 system in lung cancer may provide new insight into the interaction between adipose tissue and lung and sheds light on its potential ability to influence the lung tumor microenvironment.
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spelling pubmed-73567272020-07-22 Implications of the Adiponectin System in Non-Small Cell Lung Cancer Patients: A Case-Control Study Nigro, Ersilia Perrotta, Fabio Monaco, Maria Ludovica Polito, Rita Pafundi, Pia Clara Matera, Maria Gabriella Daniele, Aurora Bianco, Andrea Biomolecules Article Alterations of adipose tissue occurring in obesity have been recognized as a major risk factor for several cancers. The relationship between adipose tissue and lung cancer, which is the main cancer-related cause of death worldwide, still requires investigation. Perturbations in the adipokine system are likely to interfere with inter-organ crosstalk in lung cancer, which may influence the lung tumor microenvironment. Adiponectin (Acrp30) expression is deregulated in several cancer types. Acrp30 circulates as oligomers with a Low (LMW), Medium (MMW), and High Molecular Weight (HMW), with the latter mediating the main biological effects. Acrp30 acts through AdipoR1 and AdipoR2 receptors. T-cadherin has been described as a non-signaling receptor. This study’s aim was to investigate the regulation of serum Acrp30 and its receptors in sample tissue from non-small cell lung cancer (NSCLC) patients. We recruited 72 NSCLC patients and 60 healthy controls, whom we evaluated in terms of their Acpr30 levels and oligomeric profile. In addition, the expression of AdipoRs in tissues from lung cancer specimens was also measured and compared to coupled healthy lung samples. Our findings show a significant reduction of total Acrp30 levels in NSCLC patients compared to normal subjects, with a specific down-regulation of HMW oligomers. Acrp30 expression was lower in lung adenocarcinoma than other subtypes, regardless of other factors. A significantly higher expression of AdipoR1 was observed, while no differences in R2 and a lower expression of T-cadherin were found in lung cancer specimens compared to normal healthy lung tissues. Involvement of the Acrp30 system in lung cancer may provide new insight into the interaction between adipose tissue and lung and sheds light on its potential ability to influence the lung tumor microenvironment. MDPI 2020-06-18 /pmc/articles/PMC7356727/ /pubmed/32570854 http://dx.doi.org/10.3390/biom10060926 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Nigro, Ersilia
Perrotta, Fabio
Monaco, Maria Ludovica
Polito, Rita
Pafundi, Pia Clara
Matera, Maria Gabriella
Daniele, Aurora
Bianco, Andrea
Implications of the Adiponectin System in Non-Small Cell Lung Cancer Patients: A Case-Control Study
title Implications of the Adiponectin System in Non-Small Cell Lung Cancer Patients: A Case-Control Study
title_full Implications of the Adiponectin System in Non-Small Cell Lung Cancer Patients: A Case-Control Study
title_fullStr Implications of the Adiponectin System in Non-Small Cell Lung Cancer Patients: A Case-Control Study
title_full_unstemmed Implications of the Adiponectin System in Non-Small Cell Lung Cancer Patients: A Case-Control Study
title_short Implications of the Adiponectin System in Non-Small Cell Lung Cancer Patients: A Case-Control Study
title_sort implications of the adiponectin system in non-small cell lung cancer patients: a case-control study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356727/
https://www.ncbi.nlm.nih.gov/pubmed/32570854
http://dx.doi.org/10.3390/biom10060926
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