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Effects of Different Types of Exercise Training on Pulmonary Arterial Hypertension: A Systematic Review

Pulmonary arterial hypertension (PAH) represents a chronic progressive disease characterized by high blood pressure in the pulmonary arteries leading to right heart failure. The disease has been a focus of medical research for many years due to its worse prognosis and limited treatment options. The...

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Autores principales: Waller, Lena, Krüger, Karsten, Conrad, Kerstin, Weiss, Astrid, Alack, Katharina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356848/
https://www.ncbi.nlm.nih.gov/pubmed/32498263
http://dx.doi.org/10.3390/jcm9061689
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author Waller, Lena
Krüger, Karsten
Conrad, Kerstin
Weiss, Astrid
Alack, Katharina
author_facet Waller, Lena
Krüger, Karsten
Conrad, Kerstin
Weiss, Astrid
Alack, Katharina
author_sort Waller, Lena
collection PubMed
description Pulmonary arterial hypertension (PAH) represents a chronic progressive disease characterized by high blood pressure in the pulmonary arteries leading to right heart failure. The disease has been a focus of medical research for many years due to its worse prognosis and limited treatment options. The aim of this study was to systematically assess the effects of different types of exercise interventions on PAH. Electronic databases were searched until July 2019. MEDLINE database was used as the predominant source for this paper. Studies with regards to chronic physical activity in adult PAH patients are compared on retrieving evidence on cellular, physiological, and psychological alterations in the PAH setting. Twenty human studies and 12 rat trials were identified. Amongst all studies, a total of 628 human subjects and 614 rats were examined. Regular physical activity affects the production of nitric oxygen and attenuates right ventricular hypertrophy. A combination of aerobic, anaerobic, and respiratory muscle training induces the strongest improvement in functional capacity indicated by an increase of 6 MWD and VO(2) peak. In human studies, an increase of quality of life was found. Exercise training has an overall positive effect on the physiological and psychological components of PAH. Consequently, PAH patients should be encouraged to take part in regular exercise training programs.
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spelling pubmed-73568482020-07-22 Effects of Different Types of Exercise Training on Pulmonary Arterial Hypertension: A Systematic Review Waller, Lena Krüger, Karsten Conrad, Kerstin Weiss, Astrid Alack, Katharina J Clin Med Review Pulmonary arterial hypertension (PAH) represents a chronic progressive disease characterized by high blood pressure in the pulmonary arteries leading to right heart failure. The disease has been a focus of medical research for many years due to its worse prognosis and limited treatment options. The aim of this study was to systematically assess the effects of different types of exercise interventions on PAH. Electronic databases were searched until July 2019. MEDLINE database was used as the predominant source for this paper. Studies with regards to chronic physical activity in adult PAH patients are compared on retrieving evidence on cellular, physiological, and psychological alterations in the PAH setting. Twenty human studies and 12 rat trials were identified. Amongst all studies, a total of 628 human subjects and 614 rats were examined. Regular physical activity affects the production of nitric oxygen and attenuates right ventricular hypertrophy. A combination of aerobic, anaerobic, and respiratory muscle training induces the strongest improvement in functional capacity indicated by an increase of 6 MWD and VO(2) peak. In human studies, an increase of quality of life was found. Exercise training has an overall positive effect on the physiological and psychological components of PAH. Consequently, PAH patients should be encouraged to take part in regular exercise training programs. MDPI 2020-06-02 /pmc/articles/PMC7356848/ /pubmed/32498263 http://dx.doi.org/10.3390/jcm9061689 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Waller, Lena
Krüger, Karsten
Conrad, Kerstin
Weiss, Astrid
Alack, Katharina
Effects of Different Types of Exercise Training on Pulmonary Arterial Hypertension: A Systematic Review
title Effects of Different Types of Exercise Training on Pulmonary Arterial Hypertension: A Systematic Review
title_full Effects of Different Types of Exercise Training on Pulmonary Arterial Hypertension: A Systematic Review
title_fullStr Effects of Different Types of Exercise Training on Pulmonary Arterial Hypertension: A Systematic Review
title_full_unstemmed Effects of Different Types of Exercise Training on Pulmonary Arterial Hypertension: A Systematic Review
title_short Effects of Different Types of Exercise Training on Pulmonary Arterial Hypertension: A Systematic Review
title_sort effects of different types of exercise training on pulmonary arterial hypertension: a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356848/
https://www.ncbi.nlm.nih.gov/pubmed/32498263
http://dx.doi.org/10.3390/jcm9061689
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