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The Cancer Chemopreventive and Therapeutic Potential of Tetrahydrocurcumin

In recent decades, cancer has been one of the leading causes of death worldwide. Despite advances in understanding the molecular basis of tumorigenesis, diagnosis, and clinical therapies, the discovery and development of effective drugs is an active and vital field in cancer research. Tetrahydrocurc...

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Autores principales: Lai, Ching-Shu, Ho, Chi-Tang, Pan, Min-Hsiung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356876/
https://www.ncbi.nlm.nih.gov/pubmed/32486019
http://dx.doi.org/10.3390/biom10060831
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author Lai, Ching-Shu
Ho, Chi-Tang
Pan, Min-Hsiung
author_facet Lai, Ching-Shu
Ho, Chi-Tang
Pan, Min-Hsiung
author_sort Lai, Ching-Shu
collection PubMed
description In recent decades, cancer has been one of the leading causes of death worldwide. Despite advances in understanding the molecular basis of tumorigenesis, diagnosis, and clinical therapies, the discovery and development of effective drugs is an active and vital field in cancer research. Tetrahydrocurcumin is a major curcuminoid metabolite of curcumin, naturally occurring in turmeric. The interest in tetrahydrocurcumin research is increasing because it is superior to curcumin in its solubility in water, chemical stability, bioavailability, and anti-oxidative activity. Many in vitro and in vivo studies have revealed that tetrahydrocurcumin exerts anti-cancer effects through various mechanisms, including modulation of oxidative stress, xenobiotic detoxification, inflammation, proliferation, metastasis, programmed cell death, and immunity. Despite the pharmacological similarities between tetrahydrocurcumin and curcumin, the structure of tetrahydrocurcumin determines its distinct and specific molecular mechanism, thus making it a potential candidate for the prevention and treatment of cancers. However, the utility of tetrahydrocurcumin is yet to be evaluated as only limited pharmacokinetic and oral bioavailability studies have been performed. This review summarizes research on the anti-cancer properties of tetrahydrocurcumin and describes its mechanisms of action.
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spelling pubmed-73568762020-07-22 The Cancer Chemopreventive and Therapeutic Potential of Tetrahydrocurcumin Lai, Ching-Shu Ho, Chi-Tang Pan, Min-Hsiung Biomolecules Review In recent decades, cancer has been one of the leading causes of death worldwide. Despite advances in understanding the molecular basis of tumorigenesis, diagnosis, and clinical therapies, the discovery and development of effective drugs is an active and vital field in cancer research. Tetrahydrocurcumin is a major curcuminoid metabolite of curcumin, naturally occurring in turmeric. The interest in tetrahydrocurcumin research is increasing because it is superior to curcumin in its solubility in water, chemical stability, bioavailability, and anti-oxidative activity. Many in vitro and in vivo studies have revealed that tetrahydrocurcumin exerts anti-cancer effects through various mechanisms, including modulation of oxidative stress, xenobiotic detoxification, inflammation, proliferation, metastasis, programmed cell death, and immunity. Despite the pharmacological similarities between tetrahydrocurcumin and curcumin, the structure of tetrahydrocurcumin determines its distinct and specific molecular mechanism, thus making it a potential candidate for the prevention and treatment of cancers. However, the utility of tetrahydrocurcumin is yet to be evaluated as only limited pharmacokinetic and oral bioavailability studies have been performed. This review summarizes research on the anti-cancer properties of tetrahydrocurcumin and describes its mechanisms of action. MDPI 2020-05-29 /pmc/articles/PMC7356876/ /pubmed/32486019 http://dx.doi.org/10.3390/biom10060831 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lai, Ching-Shu
Ho, Chi-Tang
Pan, Min-Hsiung
The Cancer Chemopreventive and Therapeutic Potential of Tetrahydrocurcumin
title The Cancer Chemopreventive and Therapeutic Potential of Tetrahydrocurcumin
title_full The Cancer Chemopreventive and Therapeutic Potential of Tetrahydrocurcumin
title_fullStr The Cancer Chemopreventive and Therapeutic Potential of Tetrahydrocurcumin
title_full_unstemmed The Cancer Chemopreventive and Therapeutic Potential of Tetrahydrocurcumin
title_short The Cancer Chemopreventive and Therapeutic Potential of Tetrahydrocurcumin
title_sort cancer chemopreventive and therapeutic potential of tetrahydrocurcumin
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356876/
https://www.ncbi.nlm.nih.gov/pubmed/32486019
http://dx.doi.org/10.3390/biom10060831
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