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Early and Late Efficacy on Wound Healing of Silver Nanoparticle Gel in Males after Circumcision

We evaluate the early and late safety and efficacy of silver nanoparticle (AgNPs) in wound healing after circumcision. This multicenter prospective comparative non-randomized observational study compares wound dressing with AgNPs (group A) vs. gentamicin cream (group B). Follow-up included objective...

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Autores principales: Balzarro, Matteo, Rubilotta, Emanuele, Trabacchin, Nicolò, Soldano, Antonio, Cerrato, Clara, Migliorini, Filippo, Mancini, Vito, Pastore, Antonio Luigi, Carbone, Antonio, Cormio, Luigi, Carrieri, Giuseppe, Antonelli, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356923/
https://www.ncbi.nlm.nih.gov/pubmed/32545258
http://dx.doi.org/10.3390/jcm9061822
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author Balzarro, Matteo
Rubilotta, Emanuele
Trabacchin, Nicolò
Soldano, Antonio
Cerrato, Clara
Migliorini, Filippo
Mancini, Vito
Pastore, Antonio Luigi
Carbone, Antonio
Cormio, Luigi
Carrieri, Giuseppe
Antonelli, Alessandro
author_facet Balzarro, Matteo
Rubilotta, Emanuele
Trabacchin, Nicolò
Soldano, Antonio
Cerrato, Clara
Migliorini, Filippo
Mancini, Vito
Pastore, Antonio Luigi
Carbone, Antonio
Cormio, Luigi
Carrieri, Giuseppe
Antonelli, Alessandro
author_sort Balzarro, Matteo
collection PubMed
description We evaluate the early and late safety and efficacy of silver nanoparticle (AgNPs) in wound healing after circumcision. This multicenter prospective comparative non-randomized observational study compares wound dressing with AgNPs (group A) vs. gentamicin cream (group B). Follow-up included objective evaluation at 10 and 30 days by the Southampton Scoring System (SSS) and Stony Brook Scar Evaluation Scale (SBSES). We enrolled 392 males: 194 in group A, and 198 in group B. At 10 days follow-up, in group A, the SSS scale was grade 1 in 49.5% and grade 2 in the remaining; meanwhile, in group B, grade 1 was in 58%, grade 2 in 34.3%, and grade 4 in 7.6%. At 30 days follow-up, grade 1 healing was 97.4% and 98.4% in group A and B, respectively. At 10 days follow-up, the mean SBSES score was 3.58 and 3.69 in group A and B, respectively; while at 30 days follow-up, 4.81 and 4.76 in group A and B, respectively. Only in group B did 7.6% of males have antibiotic therapy due to pus discharge. No patients needed surgical wound revision. AgNPs led to a late but safer healing, they were non-inferior to the antibiotic cream wound dressing efficacy, and they avoided pus discharge and the need for oral antibiotics due to their polymer material.
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spelling pubmed-73569232020-07-22 Early and Late Efficacy on Wound Healing of Silver Nanoparticle Gel in Males after Circumcision Balzarro, Matteo Rubilotta, Emanuele Trabacchin, Nicolò Soldano, Antonio Cerrato, Clara Migliorini, Filippo Mancini, Vito Pastore, Antonio Luigi Carbone, Antonio Cormio, Luigi Carrieri, Giuseppe Antonelli, Alessandro J Clin Med Article We evaluate the early and late safety and efficacy of silver nanoparticle (AgNPs) in wound healing after circumcision. This multicenter prospective comparative non-randomized observational study compares wound dressing with AgNPs (group A) vs. gentamicin cream (group B). Follow-up included objective evaluation at 10 and 30 days by the Southampton Scoring System (SSS) and Stony Brook Scar Evaluation Scale (SBSES). We enrolled 392 males: 194 in group A, and 198 in group B. At 10 days follow-up, in group A, the SSS scale was grade 1 in 49.5% and grade 2 in the remaining; meanwhile, in group B, grade 1 was in 58%, grade 2 in 34.3%, and grade 4 in 7.6%. At 30 days follow-up, grade 1 healing was 97.4% and 98.4% in group A and B, respectively. At 10 days follow-up, the mean SBSES score was 3.58 and 3.69 in group A and B, respectively; while at 30 days follow-up, 4.81 and 4.76 in group A and B, respectively. Only in group B did 7.6% of males have antibiotic therapy due to pus discharge. No patients needed surgical wound revision. AgNPs led to a late but safer healing, they were non-inferior to the antibiotic cream wound dressing efficacy, and they avoided pus discharge and the need for oral antibiotics due to their polymer material. MDPI 2020-06-11 /pmc/articles/PMC7356923/ /pubmed/32545258 http://dx.doi.org/10.3390/jcm9061822 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Balzarro, Matteo
Rubilotta, Emanuele
Trabacchin, Nicolò
Soldano, Antonio
Cerrato, Clara
Migliorini, Filippo
Mancini, Vito
Pastore, Antonio Luigi
Carbone, Antonio
Cormio, Luigi
Carrieri, Giuseppe
Antonelli, Alessandro
Early and Late Efficacy on Wound Healing of Silver Nanoparticle Gel in Males after Circumcision
title Early and Late Efficacy on Wound Healing of Silver Nanoparticle Gel in Males after Circumcision
title_full Early and Late Efficacy on Wound Healing of Silver Nanoparticle Gel in Males after Circumcision
title_fullStr Early and Late Efficacy on Wound Healing of Silver Nanoparticle Gel in Males after Circumcision
title_full_unstemmed Early and Late Efficacy on Wound Healing of Silver Nanoparticle Gel in Males after Circumcision
title_short Early and Late Efficacy on Wound Healing of Silver Nanoparticle Gel in Males after Circumcision
title_sort early and late efficacy on wound healing of silver nanoparticle gel in males after circumcision
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356923/
https://www.ncbi.nlm.nih.gov/pubmed/32545258
http://dx.doi.org/10.3390/jcm9061822
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