Cargando…
Early and Late Efficacy on Wound Healing of Silver Nanoparticle Gel in Males after Circumcision
We evaluate the early and late safety and efficacy of silver nanoparticle (AgNPs) in wound healing after circumcision. This multicenter prospective comparative non-randomized observational study compares wound dressing with AgNPs (group A) vs. gentamicin cream (group B). Follow-up included objective...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356923/ https://www.ncbi.nlm.nih.gov/pubmed/32545258 http://dx.doi.org/10.3390/jcm9061822 |
_version_ | 1783558594200862720 |
---|---|
author | Balzarro, Matteo Rubilotta, Emanuele Trabacchin, Nicolò Soldano, Antonio Cerrato, Clara Migliorini, Filippo Mancini, Vito Pastore, Antonio Luigi Carbone, Antonio Cormio, Luigi Carrieri, Giuseppe Antonelli, Alessandro |
author_facet | Balzarro, Matteo Rubilotta, Emanuele Trabacchin, Nicolò Soldano, Antonio Cerrato, Clara Migliorini, Filippo Mancini, Vito Pastore, Antonio Luigi Carbone, Antonio Cormio, Luigi Carrieri, Giuseppe Antonelli, Alessandro |
author_sort | Balzarro, Matteo |
collection | PubMed |
description | We evaluate the early and late safety and efficacy of silver nanoparticle (AgNPs) in wound healing after circumcision. This multicenter prospective comparative non-randomized observational study compares wound dressing with AgNPs (group A) vs. gentamicin cream (group B). Follow-up included objective evaluation at 10 and 30 days by the Southampton Scoring System (SSS) and Stony Brook Scar Evaluation Scale (SBSES). We enrolled 392 males: 194 in group A, and 198 in group B. At 10 days follow-up, in group A, the SSS scale was grade 1 in 49.5% and grade 2 in the remaining; meanwhile, in group B, grade 1 was in 58%, grade 2 in 34.3%, and grade 4 in 7.6%. At 30 days follow-up, grade 1 healing was 97.4% and 98.4% in group A and B, respectively. At 10 days follow-up, the mean SBSES score was 3.58 and 3.69 in group A and B, respectively; while at 30 days follow-up, 4.81 and 4.76 in group A and B, respectively. Only in group B did 7.6% of males have antibiotic therapy due to pus discharge. No patients needed surgical wound revision. AgNPs led to a late but safer healing, they were non-inferior to the antibiotic cream wound dressing efficacy, and they avoided pus discharge and the need for oral antibiotics due to their polymer material. |
format | Online Article Text |
id | pubmed-7356923 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-73569232020-07-22 Early and Late Efficacy on Wound Healing of Silver Nanoparticle Gel in Males after Circumcision Balzarro, Matteo Rubilotta, Emanuele Trabacchin, Nicolò Soldano, Antonio Cerrato, Clara Migliorini, Filippo Mancini, Vito Pastore, Antonio Luigi Carbone, Antonio Cormio, Luigi Carrieri, Giuseppe Antonelli, Alessandro J Clin Med Article We evaluate the early and late safety and efficacy of silver nanoparticle (AgNPs) in wound healing after circumcision. This multicenter prospective comparative non-randomized observational study compares wound dressing with AgNPs (group A) vs. gentamicin cream (group B). Follow-up included objective evaluation at 10 and 30 days by the Southampton Scoring System (SSS) and Stony Brook Scar Evaluation Scale (SBSES). We enrolled 392 males: 194 in group A, and 198 in group B. At 10 days follow-up, in group A, the SSS scale was grade 1 in 49.5% and grade 2 in the remaining; meanwhile, in group B, grade 1 was in 58%, grade 2 in 34.3%, and grade 4 in 7.6%. At 30 days follow-up, grade 1 healing was 97.4% and 98.4% in group A and B, respectively. At 10 days follow-up, the mean SBSES score was 3.58 and 3.69 in group A and B, respectively; while at 30 days follow-up, 4.81 and 4.76 in group A and B, respectively. Only in group B did 7.6% of males have antibiotic therapy due to pus discharge. No patients needed surgical wound revision. AgNPs led to a late but safer healing, they were non-inferior to the antibiotic cream wound dressing efficacy, and they avoided pus discharge and the need for oral antibiotics due to their polymer material. MDPI 2020-06-11 /pmc/articles/PMC7356923/ /pubmed/32545258 http://dx.doi.org/10.3390/jcm9061822 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Balzarro, Matteo Rubilotta, Emanuele Trabacchin, Nicolò Soldano, Antonio Cerrato, Clara Migliorini, Filippo Mancini, Vito Pastore, Antonio Luigi Carbone, Antonio Cormio, Luigi Carrieri, Giuseppe Antonelli, Alessandro Early and Late Efficacy on Wound Healing of Silver Nanoparticle Gel in Males after Circumcision |
title | Early and Late Efficacy on Wound Healing of Silver Nanoparticle Gel in Males after Circumcision |
title_full | Early and Late Efficacy on Wound Healing of Silver Nanoparticle Gel in Males after Circumcision |
title_fullStr | Early and Late Efficacy on Wound Healing of Silver Nanoparticle Gel in Males after Circumcision |
title_full_unstemmed | Early and Late Efficacy on Wound Healing of Silver Nanoparticle Gel in Males after Circumcision |
title_short | Early and Late Efficacy on Wound Healing of Silver Nanoparticle Gel in Males after Circumcision |
title_sort | early and late efficacy on wound healing of silver nanoparticle gel in males after circumcision |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356923/ https://www.ncbi.nlm.nih.gov/pubmed/32545258 http://dx.doi.org/10.3390/jcm9061822 |
work_keys_str_mv | AT balzarromatteo earlyandlateefficacyonwoundhealingofsilvernanoparticlegelinmalesaftercircumcision AT rubilottaemanuele earlyandlateefficacyonwoundhealingofsilvernanoparticlegelinmalesaftercircumcision AT trabacchinnicolo earlyandlateefficacyonwoundhealingofsilvernanoparticlegelinmalesaftercircumcision AT soldanoantonio earlyandlateefficacyonwoundhealingofsilvernanoparticlegelinmalesaftercircumcision AT cerratoclara earlyandlateefficacyonwoundhealingofsilvernanoparticlegelinmalesaftercircumcision AT migliorinifilippo earlyandlateefficacyonwoundhealingofsilvernanoparticlegelinmalesaftercircumcision AT mancinivito earlyandlateefficacyonwoundhealingofsilvernanoparticlegelinmalesaftercircumcision AT pastoreantonioluigi earlyandlateefficacyonwoundhealingofsilvernanoparticlegelinmalesaftercircumcision AT carboneantonio earlyandlateefficacyonwoundhealingofsilvernanoparticlegelinmalesaftercircumcision AT cormioluigi earlyandlateefficacyonwoundhealingofsilvernanoparticlegelinmalesaftercircumcision AT carrierigiuseppe earlyandlateefficacyonwoundhealingofsilvernanoparticlegelinmalesaftercircumcision AT antonellialessandro earlyandlateefficacyonwoundhealingofsilvernanoparticlegelinmalesaftercircumcision |