NRF2 Regulation Processes as a Source of Potential Drug Targets against Neurodegenerative Diseases

NRF2 acts by controlling gene expression, being the master regulator of the Phase II antioxidant response, and also being key to the control of neuroinflammation. NRF2 activity is regulated at several levels, including protein degradation by the proteasome, transcription, and post-transcription. The...

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Detalles Bibliográficos
Autores principales: Cores, Ángel, Piquero, Marta, Villacampa, Mercedes, León, Rafael, Menéndez, J. Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356958/
https://www.ncbi.nlm.nih.gov/pubmed/32545924
http://dx.doi.org/10.3390/biom10060904
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author Cores, Ángel
Piquero, Marta
Villacampa, Mercedes
León, Rafael
Menéndez, J. Carlos
author_facet Cores, Ángel
Piquero, Marta
Villacampa, Mercedes
León, Rafael
Menéndez, J. Carlos
author_sort Cores, Ángel
collection PubMed
description NRF2 acts by controlling gene expression, being the master regulator of the Phase II antioxidant response, and also being key to the control of neuroinflammation. NRF2 activity is regulated at several levels, including protein degradation by the proteasome, transcription, and post-transcription. The purpose of this review is to offer a concise and critical overview of the main mechanisms of NRF2 regulation and their actual or potential use as targets for the treatment of neurodegenerative diseases.
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spelling pubmed-73569582020-07-23 NRF2 Regulation Processes as a Source of Potential Drug Targets against Neurodegenerative Diseases Cores, Ángel Piquero, Marta Villacampa, Mercedes León, Rafael Menéndez, J. Carlos Biomolecules Review NRF2 acts by controlling gene expression, being the master regulator of the Phase II antioxidant response, and also being key to the control of neuroinflammation. NRF2 activity is regulated at several levels, including protein degradation by the proteasome, transcription, and post-transcription. The purpose of this review is to offer a concise and critical overview of the main mechanisms of NRF2 regulation and their actual or potential use as targets for the treatment of neurodegenerative diseases. MDPI 2020-06-14 /pmc/articles/PMC7356958/ /pubmed/32545924 http://dx.doi.org/10.3390/biom10060904 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Cores, Ángel
Piquero, Marta
Villacampa, Mercedes
León, Rafael
Menéndez, J. Carlos
NRF2 Regulation Processes as a Source of Potential Drug Targets against Neurodegenerative Diseases
title NRF2 Regulation Processes as a Source of Potential Drug Targets against Neurodegenerative Diseases
title_full NRF2 Regulation Processes as a Source of Potential Drug Targets against Neurodegenerative Diseases
title_fullStr NRF2 Regulation Processes as a Source of Potential Drug Targets against Neurodegenerative Diseases
title_full_unstemmed NRF2 Regulation Processes as a Source of Potential Drug Targets against Neurodegenerative Diseases
title_short NRF2 Regulation Processes as a Source of Potential Drug Targets against Neurodegenerative Diseases
title_sort nrf2 regulation processes as a source of potential drug targets against neurodegenerative diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356958/
https://www.ncbi.nlm.nih.gov/pubmed/32545924
http://dx.doi.org/10.3390/biom10060904
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