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Approach to Pulmonary Arteriovenous Malformations: A Comprehensive Update
Pulmonary arteriovenous malformations (PAVMs) are abnormal direct vascular communications between pulmonary arteries and veins which create high-flow right-to-left shunts. They are most frequently congenital, usually in the setting of hereditary hemorrhagic telangiectasia (HHT). PAVMs may be asympto...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356967/ https://www.ncbi.nlm.nih.gov/pubmed/32575535 http://dx.doi.org/10.3390/jcm9061927 |
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author | Majumdar, Shamaita McWilliams, Justin P. |
author_facet | Majumdar, Shamaita McWilliams, Justin P. |
author_sort | Majumdar, Shamaita |
collection | PubMed |
description | Pulmonary arteriovenous malformations (PAVMs) are abnormal direct vascular communications between pulmonary arteries and veins which create high-flow right-to-left shunts. They are most frequently congenital, usually in the setting of hereditary hemorrhagic telangiectasia (HHT). PAVMs may be asymptomatic or present with a wide variety of clinical manifestations such as dyspnea, hypoxemia, or chest pain. Even when asymptomatic, presence of PAVMs increases patients’ risk of serious, potentially preventable complications including stroke or brain abscess. Transcatheter embolotherapy is considered the gold standard for treatment of PAVMs. Though previous guidelines have been published regarding the management of PAVMs, several aspects of PAVM screening and management remain debated among the experts, suggesting the need for thorough reexamination of the current literature. The authors of this review present an updated approach to the diagnostic workup and management of PAVMs, with an emphasis on areas of controversy, based on the latest literature and our institutional experience. |
format | Online Article Text |
id | pubmed-7356967 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-73569672020-07-23 Approach to Pulmonary Arteriovenous Malformations: A Comprehensive Update Majumdar, Shamaita McWilliams, Justin P. J Clin Med Review Pulmonary arteriovenous malformations (PAVMs) are abnormal direct vascular communications between pulmonary arteries and veins which create high-flow right-to-left shunts. They are most frequently congenital, usually in the setting of hereditary hemorrhagic telangiectasia (HHT). PAVMs may be asymptomatic or present with a wide variety of clinical manifestations such as dyspnea, hypoxemia, or chest pain. Even when asymptomatic, presence of PAVMs increases patients’ risk of serious, potentially preventable complications including stroke or brain abscess. Transcatheter embolotherapy is considered the gold standard for treatment of PAVMs. Though previous guidelines have been published regarding the management of PAVMs, several aspects of PAVM screening and management remain debated among the experts, suggesting the need for thorough reexamination of the current literature. The authors of this review present an updated approach to the diagnostic workup and management of PAVMs, with an emphasis on areas of controversy, based on the latest literature and our institutional experience. MDPI 2020-06-19 /pmc/articles/PMC7356967/ /pubmed/32575535 http://dx.doi.org/10.3390/jcm9061927 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Majumdar, Shamaita McWilliams, Justin P. Approach to Pulmonary Arteriovenous Malformations: A Comprehensive Update |
title | Approach to Pulmonary Arteriovenous Malformations: A Comprehensive Update |
title_full | Approach to Pulmonary Arteriovenous Malformations: A Comprehensive Update |
title_fullStr | Approach to Pulmonary Arteriovenous Malformations: A Comprehensive Update |
title_full_unstemmed | Approach to Pulmonary Arteriovenous Malformations: A Comprehensive Update |
title_short | Approach to Pulmonary Arteriovenous Malformations: A Comprehensive Update |
title_sort | approach to pulmonary arteriovenous malformations: a comprehensive update |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356967/ https://www.ncbi.nlm.nih.gov/pubmed/32575535 http://dx.doi.org/10.3390/jcm9061927 |
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