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Prognostic and clinicopathological significance of systemic immune-inflammation index in colorectal cancer: a meta-analysis

BACKGROUND: Previous studies on the systemic immune-inflammation index (SII), which is based on platelet, neutrophil and lymphocyte counts, as a prognostic marker in patients with colorectal cancer (CRC) yielded inconsistent results. The aim of this study was to evaluate the prognostic and clinicopa...

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Autores principales: Dong, Meilian, Shi, Yonggang, Yang, Jing, Zhou, Quanbo, Lian, Yugui, Wang, Dan, Ma, Taoran, Zhang, Yue, Mi, Yin, Gu, Xiaobin, Fan, Ruitai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7357045/
https://www.ncbi.nlm.nih.gov/pubmed/32699557
http://dx.doi.org/10.1177/1758835920937425
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author Dong, Meilian
Shi, Yonggang
Yang, Jing
Zhou, Quanbo
Lian, Yugui
Wang, Dan
Ma, Taoran
Zhang, Yue
Mi, Yin
Gu, Xiaobin
Fan, Ruitai
author_facet Dong, Meilian
Shi, Yonggang
Yang, Jing
Zhou, Quanbo
Lian, Yugui
Wang, Dan
Ma, Taoran
Zhang, Yue
Mi, Yin
Gu, Xiaobin
Fan, Ruitai
author_sort Dong, Meilian
collection PubMed
description BACKGROUND: Previous studies on the systemic immune-inflammation index (SII), which is based on platelet, neutrophil and lymphocyte counts, as a prognostic marker in patients with colorectal cancer (CRC) yielded inconsistent results. The aim of this study was to evaluate the prognostic and clinicopathological role of SII in CRC via meta-analysis. METHODS: A comprehensive literature survey was performed on PubMed, Web of Science, Embase and the Cochrane Library databases to include studies published up to 6 April 2020. Pooled hazard ratios (HRs) and odds ratios (ORs) with 95% confidence intervals (CIs) were computed to estimate the prognostic and clinicopathological value of SII in CRC. RESULTS: A total of 12 studies published between 2016 and 2019 were included in our meta-analysis. The combined analysis showed that high SII levels were significantly associated with worse overall survival (OS; HR = 1.61, 95% CI = 1.21–2.13, p = 0.001) and progression-free survival (HR = 1.74, 95% CI = 1.26–2.39, p = 0.001) in CRC. Moreover, elevated SII was also correlated with poor tumor differentiation (OR = 1.60, 95% CI = 1.27–2.02, p < 0.001), presence of distant metastasis (OR = 2.27, 95% CI = 1.10–4.67, p = 0.026), ECOG PS of 1–2 (OR = 1.98, 95% CI = 1.39–2.84, p < 0.001) and tumor size ⩾5 cm (OR = 1.49, 95% CI = 1.18–1.88, p = 0.001). However, high SII was not significantly associated with sex, tumor location, lymph node metastasis, or age in patients with CRC. CONCLUSION: Our meta-analysis indicated that high SII levels predicted poor prognosis in CRC. In addition, an elevated SII was also associated with clinical factors, implying higher malignancy of the disease.
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spelling pubmed-73570452020-07-21 Prognostic and clinicopathological significance of systemic immune-inflammation index in colorectal cancer: a meta-analysis Dong, Meilian Shi, Yonggang Yang, Jing Zhou, Quanbo Lian, Yugui Wang, Dan Ma, Taoran Zhang, Yue Mi, Yin Gu, Xiaobin Fan, Ruitai Ther Adv Med Oncol Meta-Analysis BACKGROUND: Previous studies on the systemic immune-inflammation index (SII), which is based on platelet, neutrophil and lymphocyte counts, as a prognostic marker in patients with colorectal cancer (CRC) yielded inconsistent results. The aim of this study was to evaluate the prognostic and clinicopathological role of SII in CRC via meta-analysis. METHODS: A comprehensive literature survey was performed on PubMed, Web of Science, Embase and the Cochrane Library databases to include studies published up to 6 April 2020. Pooled hazard ratios (HRs) and odds ratios (ORs) with 95% confidence intervals (CIs) were computed to estimate the prognostic and clinicopathological value of SII in CRC. RESULTS: A total of 12 studies published between 2016 and 2019 were included in our meta-analysis. The combined analysis showed that high SII levels were significantly associated with worse overall survival (OS; HR = 1.61, 95% CI = 1.21–2.13, p = 0.001) and progression-free survival (HR = 1.74, 95% CI = 1.26–2.39, p = 0.001) in CRC. Moreover, elevated SII was also correlated with poor tumor differentiation (OR = 1.60, 95% CI = 1.27–2.02, p < 0.001), presence of distant metastasis (OR = 2.27, 95% CI = 1.10–4.67, p = 0.026), ECOG PS of 1–2 (OR = 1.98, 95% CI = 1.39–2.84, p < 0.001) and tumor size ⩾5 cm (OR = 1.49, 95% CI = 1.18–1.88, p = 0.001). However, high SII was not significantly associated with sex, tumor location, lymph node metastasis, or age in patients with CRC. CONCLUSION: Our meta-analysis indicated that high SII levels predicted poor prognosis in CRC. In addition, an elevated SII was also associated with clinical factors, implying higher malignancy of the disease. SAGE Publications 2020-07-11 /pmc/articles/PMC7357045/ /pubmed/32699557 http://dx.doi.org/10.1177/1758835920937425 Text en © The Author(s), 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Meta-Analysis
Dong, Meilian
Shi, Yonggang
Yang, Jing
Zhou, Quanbo
Lian, Yugui
Wang, Dan
Ma, Taoran
Zhang, Yue
Mi, Yin
Gu, Xiaobin
Fan, Ruitai
Prognostic and clinicopathological significance of systemic immune-inflammation index in colorectal cancer: a meta-analysis
title Prognostic and clinicopathological significance of systemic immune-inflammation index in colorectal cancer: a meta-analysis
title_full Prognostic and clinicopathological significance of systemic immune-inflammation index in colorectal cancer: a meta-analysis
title_fullStr Prognostic and clinicopathological significance of systemic immune-inflammation index in colorectal cancer: a meta-analysis
title_full_unstemmed Prognostic and clinicopathological significance of systemic immune-inflammation index in colorectal cancer: a meta-analysis
title_short Prognostic and clinicopathological significance of systemic immune-inflammation index in colorectal cancer: a meta-analysis
title_sort prognostic and clinicopathological significance of systemic immune-inflammation index in colorectal cancer: a meta-analysis
topic Meta-Analysis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7357045/
https://www.ncbi.nlm.nih.gov/pubmed/32699557
http://dx.doi.org/10.1177/1758835920937425
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