Cargando…

Engineered Extracellular Vesicles/Exosomes as a New Tool against Neurodegenerative Diseases

Neurodegenerative diseases are commonly generated by intracellular accumulation of misfolded/aggregated mutated proteins. These abnormal protein aggregates impair the functions of mitochondria and induce oxidative stress, thereby resulting in neuronal cell death. In turn, neuronal damage induces chr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ferrantelli, Flavia, Chiozzini, Chiara, Leone, Patrizia, Manfredi, Francesco, Federico, Maurizio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7357062/ https://www.ncbi.nlm.nih.gov/pubmed/32526949 http://dx.doi.org/10.3390/pharmaceutics12060529

Ejemplares similares

Simultaneous CD8(+) T-Cell Immune Response against SARS-Cov-2 S, M, and N Induced by Endogenously Engineered Extracellular Vesicles in Both Spleen and Lungs
por: Ferrantelli, Flavia, et al.
Publicado: (2021)

N-Terminal Fatty Acids of NEF(MUT) Are Required for the CD8(+) T-Cell Immunogenicity of In Vivo Engineered Extracellular Vesicles
por: Chiozzini, Chiara, et al.
Publicado: (2020)

Long-Term Antitumor CD8(+) T Cell Immunity Induced by Endogenously Engineered Extracellular Vesicles
por: Ferrantelli, Flavia, et al.
Publicado: (2021)

The C-Terminal Domain of Nef(mut) Is Dispensable for the CD8(+) T Cell Immunogenicity of In Vivo Engineered Extracellular Vesicles
por: Chiozzini, Chiara, et al.
Publicado: (2021)

Activation of Anti-SARS-CoV-2 Human CTLs by Extracellular Vesicles Engineered with the N Viral Protein
por: Manfredi, Francesco, et al.
Publicado: (2022)

Strong SARS-CoV-2 N-Specific CD8(+) T Immunity Induced by Engineered Extracellular Vesicles Associates with Protection from Lethal Infection in Mice
por: Ferrantelli, Flavia, et al.
Publicado: (2022)

The Intracellular Delivery Of Anti-HPV16 E7 scFvs Through Engineered Extracellular Vesicles Inhibits The Proliferation Of HPV-Infected Cells
por: Ferrantelli, Flavia, et al.
Publicado: (2019)

Antiviral effect of SARS-CoV-2 N-specific CD8(+) T cells induced in lungs by engineered extracellular vesicles
por: Manfredi, Francesco, et al.
Publicado: (2023)

Antitumor HPV E7-specific CTL activity elicited by in vivo engineered exosomes produced through DNA inoculation
por: Di Bonito, Paola, et al.
Publicado: (2017)

Exploiting Manipulated Small Extracellular Vesicles to Subvert Immunosuppression at the Tumor Microenvironment through Mannose Receptor/CD206 Targeting
por: Fiani, Maria Luisa, et al.
Publicado: (2020)

SARS-CoV-2-Specific CD8(+) T-Cells in Blood but Not in the Lungs of Vaccinated K18-hACE2 Mice after Infection
por: Ferrantelli, Flavia, et al.
Publicado: (2023)

The CD8(+) T Cell-Mediated Immunity Induced by HPV-E6 Uploaded in Engineered Exosomes Is Improved by ISCOMATRIX(TM) Adjuvant
por: Manfredi, Francesco, et al.
Publicado: (2016)

Cell activation and HIV-1 replication in unstimulated CD4(+) T lymphocytes ingesting exosomes from cells expressing defective HIV-1
por: Arenaccio, Claudia, et al.
Publicado: (2014)

Latent HIV-1 is activated by exosomes from cells infected with either replication-competent or defective HIV-1
por: Arenaccio, Claudia, et al.
Publicado: (2015)

HPV-E7 Delivered by Engineered Exosomes Elicits a Protective CD8(+) T Cell-Mediated Immune Response
por: Di Bonito, Paola, et al.
Publicado: (2015)

Anti-Cancer Vaccine for HPV-Associated Neoplasms: Focus on a Therapeutic HPV Vaccine Based on a Novel Tumor Antigen Delivery Method Using Endogenously Engineered Exosomes
por: Di Bonito, Paola, et al.
Publicado: (2019)

Extracellular Vesicles in Neurodegenerative Diseases: An Update
por: Sigdel, Smara, et al.
Publicado: (2023)

Extracellular vesicles in neurodegenerative diseases: Insights and new perspectives
por: Yuan, Qian, et al.
Publicado: (2019)

Extracellular Vesicles in Brain Tumors and Neurodegenerative Diseases
por: Ciregia, Federica, et al.
Publicado: (2017)

Engineering Extracellular Vesicles with the Tools of Enzyme Prodrug Therapy
por: Fuhrmann, Gregor, et al.
Publicado: (2018)

Extracellular vesicles: Exosomes, microvesicles, and friends
por: Raposo, Graça, et al.
Publicado: (2013)

Aquaporins in Urinary Extracellular Vesicles (Exosomes)
por: Oshikawa, Sayaka, et al.
Publicado: (2016)

Engineered Extracellular Vesicles as a Reliable Tool in Cancer Nanomedicine
por: Susa, Francesca, et al.
Publicado: (2019)

Role of Glia-Derived Extracellular Vesicles in Neurodegenerative Diseases
por: Li, Tianbai, et al.
Publicado: (2021)

Extracellular vesicles in neurodegenerative diseases: A systematic review
por: Raghav, Alok, et al.
Publicado: (2022)

Extracellular vesicles, from the pathogenesis to the therapy of neurodegenerative diseases
por: Xia, Xiaohuan, et al.
Publicado: (2022)

Research progress on the role of extracellular vesicles in neurodegenerative diseases
por: Li, Zhengzhe, et al.
Publicado: (2023)

Exosomes and Extracellular Vesicles as Emerging Theranostic Platforms in Cancer Research
por: Ailuno, Giorgia, et al.
Publicado: (2020)

Pathological and therapeutic effects of extracellular vesicles in neurological and neurodegenerative diseases
por: Izquierdo-Altarejos, Paula, et al.
Publicado: (2023)

Exosomes and Other Extracellular Vesicles: The New Communicators in Parasite Infections
por: Coakley, Gillian, et al.
Publicado: (2015)

Extracellular vesicles: A new paradigm in understanding, diagnosing and treating neurodegenerative disease
por: Dar, Ghulam Hassan, et al.
Publicado: (2022)

Contribution of Extracellular Vesicles and Molecular Chaperones in Age-Related Neurodegenerative Disorders of the CNS
por: Noori, Leila, et al.
Publicado: (2023)

Strategies for Engineering of Extracellular Vesicles
por: Danilushkina, Anna A., et al.
Publicado: (2023)

Extracellular Vesicle (EV) Array: microarray capturing of exosomes and other extracellular vesicles for multiplexed phenotyping
por: Jørgensen, Malene, et al.
Publicado: (2013)

Exosomes, an Unmasked Culprit in Neurodegenerative Diseases
por: Soria, Federico N., et al.
Publicado: (2017)

Extracellular Vesicles in Hematological Malignancies: From Biomarkers to Therapeutic Tools
por: Khalife, Jihane, et al.
Publicado: (2020)

Engineered Cas9 extracellular vesicles as a novel gene editing tool
por: Osteikoetxea, Xabier, et al.
Publicado: (2022)

Exosomes and Other Extracellular Vesicles in HPV Transmission and Carcinogenesis
por: Guenat, David, et al.
Publicado: (2017)

Extracellular Vesicles and Exosomes: Insights From Exercise Science
por: Nederveen, Joshua P., et al.
Publicado: (2021)

The Protective Effect of Exercise in Neurodegenerative Diseases: The Potential Role of Extracellular Vesicles
por: Fuller, Oliver K, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_d9oc11d7uo9ufrn3ca3p4c9oa5