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A Clinical Perspective on the Antimicrobial Resistance Spectrum of Uropathogens in a Romanian Male Population
Considering urinary tract infections (UTIs), a significant public health problem with negligible recent research, especially on the male eastern European population, we aimed to determine the antimicrobial resistance rates of uropathogens for the most commonly used antibiotics in urological practice...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7357063/ https://www.ncbi.nlm.nih.gov/pubmed/32516902 http://dx.doi.org/10.3390/microorganisms8060848 |
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author | Chibelean, Călin Bogdan Petca, Răzvan-Cosmin Mareș, Cristian Popescu, Răzvan-Ionuț Enikő, Barabás Mehedințu, Claudia Petca, Aida |
author_facet | Chibelean, Călin Bogdan Petca, Răzvan-Cosmin Mareș, Cristian Popescu, Răzvan-Ionuț Enikő, Barabás Mehedințu, Claudia Petca, Aida |
author_sort | Chibelean, Călin Bogdan |
collection | PubMed |
description | Considering urinary tract infections (UTIs), a significant public health problem with negligible recent research, especially on the male eastern European population, we aimed to determine the antimicrobial resistance rates of uropathogens for the most commonly used antibiotics in urological practice in our country. We conducted a multicenter retrospective study in two different teaching hospitals in Romania, analyzing urine samples from 7719 patients to determine the frequency of incriminating pathogens and their resistance to different antibiotics, in a comparative approach. We determined Escherichia coli (35.98%) to be the most common pathogen with the highest sensitivity to amikacin (S = 91.72%), meropenem (S = 97.17%) and fosfomycin (S = 86.60%) and important resistance to amoxicillin-clavulanic ac. (R = 28.03%) and levofloxacin (R = 37.69%), followed by Klebsiella spp. (22.98%) with the highest sensitivity to amikacin (S = 78.04%) and meropenem (S = 81.35%) and important resistance to amoxicillin-clavulanic ac. (R = 65.58%) and levofloxacin (R = 45.36%); the most frequent Gram-positive pathogen was Enterococcus spp. (19.73%) with the highest sensitivity for vancomycin (S = 93.75%) and fosfomycin (S = 87.5%) and considerable resistance to penicillin (R = 33.52%) and levofloxacin (R = 42.04%). The findings are an important tool in managing UTIs and should be acknowledged as reference research not only for clinicians from Romania but for all physicians treating male UTIs. |
format | Online Article Text |
id | pubmed-7357063 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-73570632020-07-23 A Clinical Perspective on the Antimicrobial Resistance Spectrum of Uropathogens in a Romanian Male Population Chibelean, Călin Bogdan Petca, Răzvan-Cosmin Mareș, Cristian Popescu, Răzvan-Ionuț Enikő, Barabás Mehedințu, Claudia Petca, Aida Microorganisms Article Considering urinary tract infections (UTIs), a significant public health problem with negligible recent research, especially on the male eastern European population, we aimed to determine the antimicrobial resistance rates of uropathogens for the most commonly used antibiotics in urological practice in our country. We conducted a multicenter retrospective study in two different teaching hospitals in Romania, analyzing urine samples from 7719 patients to determine the frequency of incriminating pathogens and their resistance to different antibiotics, in a comparative approach. We determined Escherichia coli (35.98%) to be the most common pathogen with the highest sensitivity to amikacin (S = 91.72%), meropenem (S = 97.17%) and fosfomycin (S = 86.60%) and important resistance to amoxicillin-clavulanic ac. (R = 28.03%) and levofloxacin (R = 37.69%), followed by Klebsiella spp. (22.98%) with the highest sensitivity to amikacin (S = 78.04%) and meropenem (S = 81.35%) and important resistance to amoxicillin-clavulanic ac. (R = 65.58%) and levofloxacin (R = 45.36%); the most frequent Gram-positive pathogen was Enterococcus spp. (19.73%) with the highest sensitivity for vancomycin (S = 93.75%) and fosfomycin (S = 87.5%) and considerable resistance to penicillin (R = 33.52%) and levofloxacin (R = 42.04%). The findings are an important tool in managing UTIs and should be acknowledged as reference research not only for clinicians from Romania but for all physicians treating male UTIs. MDPI 2020-06-05 /pmc/articles/PMC7357063/ /pubmed/32516902 http://dx.doi.org/10.3390/microorganisms8060848 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Chibelean, Călin Bogdan Petca, Răzvan-Cosmin Mareș, Cristian Popescu, Răzvan-Ionuț Enikő, Barabás Mehedințu, Claudia Petca, Aida A Clinical Perspective on the Antimicrobial Resistance Spectrum of Uropathogens in a Romanian Male Population |
title | A Clinical Perspective on the Antimicrobial Resistance Spectrum of Uropathogens in a Romanian Male Population |
title_full | A Clinical Perspective on the Antimicrobial Resistance Spectrum of Uropathogens in a Romanian Male Population |
title_fullStr | A Clinical Perspective on the Antimicrobial Resistance Spectrum of Uropathogens in a Romanian Male Population |
title_full_unstemmed | A Clinical Perspective on the Antimicrobial Resistance Spectrum of Uropathogens in a Romanian Male Population |
title_short | A Clinical Perspective on the Antimicrobial Resistance Spectrum of Uropathogens in a Romanian Male Population |
title_sort | clinical perspective on the antimicrobial resistance spectrum of uropathogens in a romanian male population |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7357063/ https://www.ncbi.nlm.nih.gov/pubmed/32516902 http://dx.doi.org/10.3390/microorganisms8060848 |
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