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Impact of Improvement in Walking Speed on Hospitalization and Mortality in Females with Cardiovascular Disease

Cardiovascular disease (CVD) is the principal cause of death in women. Walking speed (WS) is strongly related with mortality and CVD. The rate of all-cause hospitalization or death was assessed in 290 female outpatients with CVD after participation in a cardiac rehabilitation/secondary prevention pr...

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Autores principales: Grazzi, Giovanni, Mazzoni, Gianni, Myers, Jonathan, Caruso, Lorenzo, Sassone, Biagio, Pasanisi, Giovanni, Guerzoni, Franco, Napoli, Nicola, Pizzolato, Matteo, Zerbini, Valentina, Franchi, Michele, Masotti, Sabrina, Mandini, Simona, Raisi, Andrea, Chiaranda, Giorgio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7357156/
https://www.ncbi.nlm.nih.gov/pubmed/32517001
http://dx.doi.org/10.3390/jcm9061755
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author Grazzi, Giovanni
Mazzoni, Gianni
Myers, Jonathan
Caruso, Lorenzo
Sassone, Biagio
Pasanisi, Giovanni
Guerzoni, Franco
Napoli, Nicola
Pizzolato, Matteo
Zerbini, Valentina
Franchi, Michele
Masotti, Sabrina
Mandini, Simona
Raisi, Andrea
Chiaranda, Giorgio
author_facet Grazzi, Giovanni
Mazzoni, Gianni
Myers, Jonathan
Caruso, Lorenzo
Sassone, Biagio
Pasanisi, Giovanni
Guerzoni, Franco
Napoli, Nicola
Pizzolato, Matteo
Zerbini, Valentina
Franchi, Michele
Masotti, Sabrina
Mandini, Simona
Raisi, Andrea
Chiaranda, Giorgio
author_sort Grazzi, Giovanni
collection PubMed
description Cardiovascular disease (CVD) is the principal cause of death in women. Walking speed (WS) is strongly related with mortality and CVD. The rate of all-cause hospitalization or death was assessed in 290 female outpatients with CVD after participation in a cardiac rehabilitation/secondary prevention program (CR/SP) and associated with the WS maintained during a moderate 1 km treadmill-walk. Three-year mortality rates were 57%, 44%, and 29% for the slow (2.1 ± 0.4 km/h), moderate (3.1 ± 0.3 km/h), and fast (4.3 ± 0.6 km/h) walkers, respectively, with adjusted hazard ratios (HRs) of 0.78 (p = 0.24) and 0.55 (p = 0.03) for moderate and fast walkers compared to the slow walkers. In addition, hospitalization or death was examined four to six years after enrollment as a function of the change in the WS of 176 patients re-assessed during the third year after baseline. The rates of hospitalization or death were higher across tertiles of reduced WS, with 35%, 50%, and 53% for the high (1.5 ± 0.3 km/h), intermediate (0.7 ± 0.2 km/h), and low tertiles (0.2 ± 0.2 km/h). Adjusted HRs were 0.79 (p = 0.38) for the intermediate and 0.47 (p = 0.02) for the high tertile compared to the low improvement tertile. Improved walking speed was associated with a graded decrease in hospitalization or death from any cause in women undergoing CR/SP.
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spelling pubmed-73571562020-07-23 Impact of Improvement in Walking Speed on Hospitalization and Mortality in Females with Cardiovascular Disease Grazzi, Giovanni Mazzoni, Gianni Myers, Jonathan Caruso, Lorenzo Sassone, Biagio Pasanisi, Giovanni Guerzoni, Franco Napoli, Nicola Pizzolato, Matteo Zerbini, Valentina Franchi, Michele Masotti, Sabrina Mandini, Simona Raisi, Andrea Chiaranda, Giorgio J Clin Med Article Cardiovascular disease (CVD) is the principal cause of death in women. Walking speed (WS) is strongly related with mortality and CVD. The rate of all-cause hospitalization or death was assessed in 290 female outpatients with CVD after participation in a cardiac rehabilitation/secondary prevention program (CR/SP) and associated with the WS maintained during a moderate 1 km treadmill-walk. Three-year mortality rates were 57%, 44%, and 29% for the slow (2.1 ± 0.4 km/h), moderate (3.1 ± 0.3 km/h), and fast (4.3 ± 0.6 km/h) walkers, respectively, with adjusted hazard ratios (HRs) of 0.78 (p = 0.24) and 0.55 (p = 0.03) for moderate and fast walkers compared to the slow walkers. In addition, hospitalization or death was examined four to six years after enrollment as a function of the change in the WS of 176 patients re-assessed during the third year after baseline. The rates of hospitalization or death were higher across tertiles of reduced WS, with 35%, 50%, and 53% for the high (1.5 ± 0.3 km/h), intermediate (0.7 ± 0.2 km/h), and low tertiles (0.2 ± 0.2 km/h). Adjusted HRs were 0.79 (p = 0.38) for the intermediate and 0.47 (p = 0.02) for the high tertile compared to the low improvement tertile. Improved walking speed was associated with a graded decrease in hospitalization or death from any cause in women undergoing CR/SP. MDPI 2020-06-05 /pmc/articles/PMC7357156/ /pubmed/32517001 http://dx.doi.org/10.3390/jcm9061755 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Grazzi, Giovanni
Mazzoni, Gianni
Myers, Jonathan
Caruso, Lorenzo
Sassone, Biagio
Pasanisi, Giovanni
Guerzoni, Franco
Napoli, Nicola
Pizzolato, Matteo
Zerbini, Valentina
Franchi, Michele
Masotti, Sabrina
Mandini, Simona
Raisi, Andrea
Chiaranda, Giorgio
Impact of Improvement in Walking Speed on Hospitalization and Mortality in Females with Cardiovascular Disease
title Impact of Improvement in Walking Speed on Hospitalization and Mortality in Females with Cardiovascular Disease
title_full Impact of Improvement in Walking Speed on Hospitalization and Mortality in Females with Cardiovascular Disease
title_fullStr Impact of Improvement in Walking Speed on Hospitalization and Mortality in Females with Cardiovascular Disease
title_full_unstemmed Impact of Improvement in Walking Speed on Hospitalization and Mortality in Females with Cardiovascular Disease
title_short Impact of Improvement in Walking Speed on Hospitalization and Mortality in Females with Cardiovascular Disease
title_sort impact of improvement in walking speed on hospitalization and mortality in females with cardiovascular disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7357156/
https://www.ncbi.nlm.nih.gov/pubmed/32517001
http://dx.doi.org/10.3390/jcm9061755
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