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Investigation of the cumulative number of chromosome aberrations induced by three consecutive CT examinations in eight patients

In our previous study, we found that chromosomes were damaged by the radiation exposure from a single computed tomography (CT) examination, based on an increased number of dicentric chromosomes (Dics) formed in peripheral blood lymphocytes after a CT examination. We then investigated whether a cumul...

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Autores principales: Abe, Yu, Noji, Hideyoshi, Miura, Tomisato, Sugai, Misaki, Kurosu, Yumiko, Ujiie, Risa, Tsuyama, Naohiro, Yanagi, Aki, Yanai, Yukari, Ohba, Takashi, Ishikawa, Tetsuo, Kamiya, Kenji, Yoshida, Mitsuaki A, Sakai, Akia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7357232/
https://www.ncbi.nlm.nih.gov/pubmed/31665444
http://dx.doi.org/10.1093/jrr/rrz068
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author Abe, Yu
Noji, Hideyoshi
Miura, Tomisato
Sugai, Misaki
Kurosu, Yumiko
Ujiie, Risa
Tsuyama, Naohiro
Yanagi, Aki
Yanai, Yukari
Ohba, Takashi
Ishikawa, Tetsuo
Kamiya, Kenji
Yoshida, Mitsuaki A
Sakai, Akia
author_facet Abe, Yu
Noji, Hideyoshi
Miura, Tomisato
Sugai, Misaki
Kurosu, Yumiko
Ujiie, Risa
Tsuyama, Naohiro
Yanagi, Aki
Yanai, Yukari
Ohba, Takashi
Ishikawa, Tetsuo
Kamiya, Kenji
Yoshida, Mitsuaki A
Sakai, Akia
author_sort Abe, Yu
collection PubMed
description In our previous study, we found that chromosomes were damaged by the radiation exposure from a single computed tomography (CT) examination, based on an increased number of dicentric chromosomes (Dics) formed in peripheral blood lymphocytes after a CT examination. We then investigated whether a cumulative increase in the frequency of Dics and chromosome translocations (Trs) formation could be observed during three consecutive CT examinations performed over the course of 3–4 years, using lymphocytes in peripheral bloods of eight patients (five males and three females; age range 27–77 years; mean age, 64 years). The effective radiation dose per CT examination estimated from the computational dosimetry system was 22.0–73.5 mSv, and the average dose per case was 40.5 mSv. The frequency of Dics formation significantly increased after a CT examination and tended to decrease before the next examination. Unlike Dics analysis, we found no significant increase in the frequency of Trs formation before and after the CT examination, and we observed no tendency for the frequency to decrease before the next CT examination. The frequency of Trs formation was higher than that of Dics formation regardless of CT examination. Furthermore, neither analysis of Dics nor Trs showed a cumulative increase in the frequency of formation following three consecutive CT examinations.
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spelling pubmed-73572322020-07-16 Investigation of the cumulative number of chromosome aberrations induced by three consecutive CT examinations in eight patients Abe, Yu Noji, Hideyoshi Miura, Tomisato Sugai, Misaki Kurosu, Yumiko Ujiie, Risa Tsuyama, Naohiro Yanagi, Aki Yanai, Yukari Ohba, Takashi Ishikawa, Tetsuo Kamiya, Kenji Yoshida, Mitsuaki A Sakai, Akia J Radiat Res Regular Paper In our previous study, we found that chromosomes were damaged by the radiation exposure from a single computed tomography (CT) examination, based on an increased number of dicentric chromosomes (Dics) formed in peripheral blood lymphocytes after a CT examination. We then investigated whether a cumulative increase in the frequency of Dics and chromosome translocations (Trs) formation could be observed during three consecutive CT examinations performed over the course of 3–4 years, using lymphocytes in peripheral bloods of eight patients (five males and three females; age range 27–77 years; mean age, 64 years). The effective radiation dose per CT examination estimated from the computational dosimetry system was 22.0–73.5 mSv, and the average dose per case was 40.5 mSv. The frequency of Dics formation significantly increased after a CT examination and tended to decrease before the next examination. Unlike Dics analysis, we found no significant increase in the frequency of Trs formation before and after the CT examination, and we observed no tendency for the frequency to decrease before the next CT examination. The frequency of Trs formation was higher than that of Dics formation regardless of CT examination. Furthermore, neither analysis of Dics nor Trs showed a cumulative increase in the frequency of formation following three consecutive CT examinations. Oxford University Press 2019-11 2019-10-28 /pmc/articles/PMC7357232/ /pubmed/31665444 http://dx.doi.org/10.1093/jrr/rrz068 Text en © The Author(s) 2019. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Radiation Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Regular Paper
Abe, Yu
Noji, Hideyoshi
Miura, Tomisato
Sugai, Misaki
Kurosu, Yumiko
Ujiie, Risa
Tsuyama, Naohiro
Yanagi, Aki
Yanai, Yukari
Ohba, Takashi
Ishikawa, Tetsuo
Kamiya, Kenji
Yoshida, Mitsuaki A
Sakai, Akia
Investigation of the cumulative number of chromosome aberrations induced by three consecutive CT examinations in eight patients
title Investigation of the cumulative number of chromosome aberrations induced by three consecutive CT examinations in eight patients
title_full Investigation of the cumulative number of chromosome aberrations induced by three consecutive CT examinations in eight patients
title_fullStr Investigation of the cumulative number of chromosome aberrations induced by three consecutive CT examinations in eight patients
title_full_unstemmed Investigation of the cumulative number of chromosome aberrations induced by three consecutive CT examinations in eight patients
title_short Investigation of the cumulative number of chromosome aberrations induced by three consecutive CT examinations in eight patients
title_sort investigation of the cumulative number of chromosome aberrations induced by three consecutive ct examinations in eight patients
topic Regular Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7357232/
https://www.ncbi.nlm.nih.gov/pubmed/31665444
http://dx.doi.org/10.1093/jrr/rrz068
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