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Investigation of the cumulative number of chromosome aberrations induced by three consecutive CT examinations in eight patients
In our previous study, we found that chromosomes were damaged by the radiation exposure from a single computed tomography (CT) examination, based on an increased number of dicentric chromosomes (Dics) formed in peripheral blood lymphocytes after a CT examination. We then investigated whether a cumul...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7357232/ https://www.ncbi.nlm.nih.gov/pubmed/31665444 http://dx.doi.org/10.1093/jrr/rrz068 |
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author | Abe, Yu Noji, Hideyoshi Miura, Tomisato Sugai, Misaki Kurosu, Yumiko Ujiie, Risa Tsuyama, Naohiro Yanagi, Aki Yanai, Yukari Ohba, Takashi Ishikawa, Tetsuo Kamiya, Kenji Yoshida, Mitsuaki A Sakai, Akia |
author_facet | Abe, Yu Noji, Hideyoshi Miura, Tomisato Sugai, Misaki Kurosu, Yumiko Ujiie, Risa Tsuyama, Naohiro Yanagi, Aki Yanai, Yukari Ohba, Takashi Ishikawa, Tetsuo Kamiya, Kenji Yoshida, Mitsuaki A Sakai, Akia |
author_sort | Abe, Yu |
collection | PubMed |
description | In our previous study, we found that chromosomes were damaged by the radiation exposure from a single computed tomography (CT) examination, based on an increased number of dicentric chromosomes (Dics) formed in peripheral blood lymphocytes after a CT examination. We then investigated whether a cumulative increase in the frequency of Dics and chromosome translocations (Trs) formation could be observed during three consecutive CT examinations performed over the course of 3–4 years, using lymphocytes in peripheral bloods of eight patients (five males and three females; age range 27–77 years; mean age, 64 years). The effective radiation dose per CT examination estimated from the computational dosimetry system was 22.0–73.5 mSv, and the average dose per case was 40.5 mSv. The frequency of Dics formation significantly increased after a CT examination and tended to decrease before the next examination. Unlike Dics analysis, we found no significant increase in the frequency of Trs formation before and after the CT examination, and we observed no tendency for the frequency to decrease before the next CT examination. The frequency of Trs formation was higher than that of Dics formation regardless of CT examination. Furthermore, neither analysis of Dics nor Trs showed a cumulative increase in the frequency of formation following three consecutive CT examinations. |
format | Online Article Text |
id | pubmed-7357232 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-73572322020-07-16 Investigation of the cumulative number of chromosome aberrations induced by three consecutive CT examinations in eight patients Abe, Yu Noji, Hideyoshi Miura, Tomisato Sugai, Misaki Kurosu, Yumiko Ujiie, Risa Tsuyama, Naohiro Yanagi, Aki Yanai, Yukari Ohba, Takashi Ishikawa, Tetsuo Kamiya, Kenji Yoshida, Mitsuaki A Sakai, Akia J Radiat Res Regular Paper In our previous study, we found that chromosomes were damaged by the radiation exposure from a single computed tomography (CT) examination, based on an increased number of dicentric chromosomes (Dics) formed in peripheral blood lymphocytes after a CT examination. We then investigated whether a cumulative increase in the frequency of Dics and chromosome translocations (Trs) formation could be observed during three consecutive CT examinations performed over the course of 3–4 years, using lymphocytes in peripheral bloods of eight patients (five males and three females; age range 27–77 years; mean age, 64 years). The effective radiation dose per CT examination estimated from the computational dosimetry system was 22.0–73.5 mSv, and the average dose per case was 40.5 mSv. The frequency of Dics formation significantly increased after a CT examination and tended to decrease before the next examination. Unlike Dics analysis, we found no significant increase in the frequency of Trs formation before and after the CT examination, and we observed no tendency for the frequency to decrease before the next CT examination. The frequency of Trs formation was higher than that of Dics formation regardless of CT examination. Furthermore, neither analysis of Dics nor Trs showed a cumulative increase in the frequency of formation following three consecutive CT examinations. Oxford University Press 2019-11 2019-10-28 /pmc/articles/PMC7357232/ /pubmed/31665444 http://dx.doi.org/10.1093/jrr/rrz068 Text en © The Author(s) 2019. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Radiation Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Regular Paper Abe, Yu Noji, Hideyoshi Miura, Tomisato Sugai, Misaki Kurosu, Yumiko Ujiie, Risa Tsuyama, Naohiro Yanagi, Aki Yanai, Yukari Ohba, Takashi Ishikawa, Tetsuo Kamiya, Kenji Yoshida, Mitsuaki A Sakai, Akia Investigation of the cumulative number of chromosome aberrations induced by three consecutive CT examinations in eight patients |
title | Investigation of the cumulative number of chromosome aberrations induced by three consecutive CT examinations in eight patients |
title_full | Investigation of the cumulative number of chromosome aberrations induced by three consecutive CT examinations in eight patients |
title_fullStr | Investigation of the cumulative number of chromosome aberrations induced by three consecutive CT examinations in eight patients |
title_full_unstemmed | Investigation of the cumulative number of chromosome aberrations induced by three consecutive CT examinations in eight patients |
title_short | Investigation of the cumulative number of chromosome aberrations induced by three consecutive CT examinations in eight patients |
title_sort | investigation of the cumulative number of chromosome aberrations induced by three consecutive ct examinations in eight patients |
topic | Regular Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7357232/ https://www.ncbi.nlm.nih.gov/pubmed/31665444 http://dx.doi.org/10.1093/jrr/rrz068 |
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