Contact Transmission of Vaccinia to an Infant Diagnosed by Viral Culture and Metagenomic Sequencing

Targeted molecular diagnostic tests and accurate immunoassays have transformed the landscape of clinical virology, calling into question the usefulness of traditional viral culture. Here we present a case where viral culture, followed by metagenomic sequencing, was central to the diagnosis of an une...

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Autores principales: Martin, Rebekah M, Burke, Kristina, Verma, Dinesh, Xie, Heng, Langer, Janine, Schlaberg, Robert, Swaminathan, Sankar, Hanson, Kimberly E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7357282/
https://www.ncbi.nlm.nih.gov/pubmed/32685604
http://dx.doi.org/10.1093/ofid/ofaa111
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author Martin, Rebekah M
Burke, Kristina
Verma, Dinesh
Xie, Heng
Langer, Janine
Schlaberg, Robert
Swaminathan, Sankar
Hanson, Kimberly E
author_facet Martin, Rebekah M
Burke, Kristina
Verma, Dinesh
Xie, Heng
Langer, Janine
Schlaberg, Robert
Swaminathan, Sankar
Hanson, Kimberly E
author_sort Martin, Rebekah M
collection PubMed
description Targeted molecular diagnostic tests and accurate immunoassays have transformed the landscape of clinical virology, calling into question the usefulness of traditional viral culture. Here we present a case where viral culture, followed by metagenomic sequencing, was central to the diagnosis of an unexpected viral infection, with significant clinical and public health implications.
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spelling pubmed-73572822020-07-16 Contact Transmission of Vaccinia to an Infant Diagnosed by Viral Culture and Metagenomic Sequencing Martin, Rebekah M Burke, Kristina Verma, Dinesh Xie, Heng Langer, Janine Schlaberg, Robert Swaminathan, Sankar Hanson, Kimberly E Open Forum Infect Dis Brief Report Targeted molecular diagnostic tests and accurate immunoassays have transformed the landscape of clinical virology, calling into question the usefulness of traditional viral culture. Here we present a case where viral culture, followed by metagenomic sequencing, was central to the diagnosis of an unexpected viral infection, with significant clinical and public health implications. Oxford University Press 2020-03-28 /pmc/articles/PMC7357282/ /pubmed/32685604 http://dx.doi.org/10.1093/ofid/ofaa111 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
Martin, Rebekah M
Burke, Kristina
Verma, Dinesh
Xie, Heng
Langer, Janine
Schlaberg, Robert
Swaminathan, Sankar
Hanson, Kimberly E
Contact Transmission of Vaccinia to an Infant Diagnosed by Viral Culture and Metagenomic Sequencing
title Contact Transmission of Vaccinia to an Infant Diagnosed by Viral Culture and Metagenomic Sequencing
title_full Contact Transmission of Vaccinia to an Infant Diagnosed by Viral Culture and Metagenomic Sequencing
title_fullStr Contact Transmission of Vaccinia to an Infant Diagnosed by Viral Culture and Metagenomic Sequencing
title_full_unstemmed Contact Transmission of Vaccinia to an Infant Diagnosed by Viral Culture and Metagenomic Sequencing
title_short Contact Transmission of Vaccinia to an Infant Diagnosed by Viral Culture and Metagenomic Sequencing
title_sort contact transmission of vaccinia to an infant diagnosed by viral culture and metagenomic sequencing
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7357282/
https://www.ncbi.nlm.nih.gov/pubmed/32685604
http://dx.doi.org/10.1093/ofid/ofaa111
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