The renin–angiotensin–aldosterone system: Role in pathogenesis and potential therapeutic target in COVID‐19

Coronavirus disease 2019 (COVID‐19), caused by the SARS‐CoV‐2 novel coronavirus, has spread worldwide causing high fatality rates. Neither a vaccine nor specific therapeutic approaches are available, hindering the fight against this disease and making better understanding of its pathogenesis essenti...

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Autores principales: Braga, Cássia L., Silva‐Aguiar, Rodrigo P., Battaglini, Denise, Peruchetti, Diogo B., Robba, Chiara, Pelosi, Paolo, Rocco, Patricia R. M., Caruso‐Neves, Celso, Silva, Pedro L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7357286/
https://www.ncbi.nlm.nih.gov/pubmed/32658389
http://dx.doi.org/10.1002/prp2.623
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author Braga, Cássia L.
Silva‐Aguiar, Rodrigo P.
Battaglini, Denise
Peruchetti, Diogo B.
Robba, Chiara
Pelosi, Paolo
Rocco, Patricia R. M.
Caruso‐Neves, Celso
Silva, Pedro L.
author_facet Braga, Cássia L.
Silva‐Aguiar, Rodrigo P.
Battaglini, Denise
Peruchetti, Diogo B.
Robba, Chiara
Pelosi, Paolo
Rocco, Patricia R. M.
Caruso‐Neves, Celso
Silva, Pedro L.
author_sort Braga, Cássia L.
collection PubMed
description Coronavirus disease 2019 (COVID‐19), caused by the SARS‐CoV‐2 novel coronavirus, has spread worldwide causing high fatality rates. Neither a vaccine nor specific therapeutic approaches are available, hindering the fight against this disease and making better understanding of its pathogenesis essential. Despite similarities between SARS‐CoV‐2 and SARS‐CoV, the former has unique characteristics which represent a great challenge to physicians. The mechanism of COVID‐19 infection and pathogenesis is still poorly understood. In the present review, we highlight possible pathways involved in the pathogenesis of COVID‐19 and potential therapeutic targets, focusing on the role of the renin–angiotensin–aldosterone system.
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spelling pubmed-73572862020-07-17 The renin–angiotensin–aldosterone system: Role in pathogenesis and potential therapeutic target in COVID‐19 Braga, Cássia L. Silva‐Aguiar, Rodrigo P. Battaglini, Denise Peruchetti, Diogo B. Robba, Chiara Pelosi, Paolo Rocco, Patricia R. M. Caruso‐Neves, Celso Silva, Pedro L. Pharmacol Res Perspect Reviews Coronavirus disease 2019 (COVID‐19), caused by the SARS‐CoV‐2 novel coronavirus, has spread worldwide causing high fatality rates. Neither a vaccine nor specific therapeutic approaches are available, hindering the fight against this disease and making better understanding of its pathogenesis essential. Despite similarities between SARS‐CoV‐2 and SARS‐CoV, the former has unique characteristics which represent a great challenge to physicians. The mechanism of COVID‐19 infection and pathogenesis is still poorly understood. In the present review, we highlight possible pathways involved in the pathogenesis of COVID‐19 and potential therapeutic targets, focusing on the role of the renin–angiotensin–aldosterone system. John Wiley and Sons Inc. 2020-07-13 /pmc/articles/PMC7357286/ /pubmed/32658389 http://dx.doi.org/10.1002/prp2.623 Text en © 2020 The Authors. Pharmacology Research & Perspectives published by John Wiley & Sons Ltd, British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Braga, Cássia L.
Silva‐Aguiar, Rodrigo P.
Battaglini, Denise
Peruchetti, Diogo B.
Robba, Chiara
Pelosi, Paolo
Rocco, Patricia R. M.
Caruso‐Neves, Celso
Silva, Pedro L.
The renin–angiotensin–aldosterone system: Role in pathogenesis and potential therapeutic target in COVID‐19
title The renin–angiotensin–aldosterone system: Role in pathogenesis and potential therapeutic target in COVID‐19
title_full The renin–angiotensin–aldosterone system: Role in pathogenesis and potential therapeutic target in COVID‐19
title_fullStr The renin–angiotensin–aldosterone system: Role in pathogenesis and potential therapeutic target in COVID‐19
title_full_unstemmed The renin–angiotensin–aldosterone system: Role in pathogenesis and potential therapeutic target in COVID‐19
title_short The renin–angiotensin–aldosterone system: Role in pathogenesis and potential therapeutic target in COVID‐19
title_sort renin–angiotensin–aldosterone system: role in pathogenesis and potential therapeutic target in covid‐19
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7357286/
https://www.ncbi.nlm.nih.gov/pubmed/32658389
http://dx.doi.org/10.1002/prp2.623
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