Cargando…
When Does the IC(50) Accurately Assess the Blocking Potency of a Drug?
[Image: see text] Preclinical assessment of drug-induced proarrhythmicity is typically evaluated by the potency of the drug to block the potassium human ether-à-go-go-related gene (hERG) channels, which is currently quantified by the IC(50). However, channel block depends on the experimental conditi...
| Autores principales: | , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2020
|
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7357848/ https://www.ncbi.nlm.nih.gov/pubmed/32105478 http://dx.doi.org/10.1021/acs.jcim.9b01085 |