Cargando…

急性白血病患者化疗后骨髓抑制期血浆凝血因子XIII水平及其对出血事件的影响

OBJECTIVE: To explore the relationship between plasma coagulation factor XIII (FXIII) and bleeding events. METHODS: A total of 55 cases of acute leukemia (AL) at the myelosuppression phase after chemotherapy hospitalized in our hospital from August 2017 to March 2018 were enrolled, with 35 normal co...

Descripción completa

Detalles Bibliográficos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Editorial office of Chinese Journal of Hematology 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7357909/
https://www.ncbi.nlm.nih.gov/pubmed/32023756
http://dx.doi.org/10.3760/cma.j.issn.0253-2727.2020.01.011
_version_ 1783558752336609280
collection PubMed
description OBJECTIVE: To explore the relationship between plasma coagulation factor XIII (FXIII) and bleeding events. METHODS: A total of 55 cases of acute leukemia (AL) at the myelosuppression phase after chemotherapy hospitalized in our hospital from August 2017 to March 2018 were enrolled, with 35 normal controls. The concentration of plasma coagulation factor XIII (FXIII) was detected by ELISA to determine the relationship between the plasma FXIII levels in AL patients at the myelosuppression phase after chemotherapy with bleeding events. RESULTS: The level of FXIII in AL patients at the myelosuppression phase after chemotherapy was significantly lower than that in controls (P<0.001). The level of FXIII was inversely related with the bleeding severity (the Spearman correlation coefficient -0.761). Given the diagnosis cut-off point of FXIII concentration as 103.9 µg/L, the sensitivity of diagnosing bleeding in AL patients at the myelosuppression phase after chemotherapy was 0.939, and the specificity 0.909. CONCLUSION: AL patients at the myelosuppression phase after chemotherapy had low level of plasma FXIII, and patients with lower plasma FXIII associated with higher incidence and severity of bleeding. FXIII level was an independent influencing factor of bleeding in AL patients at the myelosuppression phase after chemotherapy.
format Online
Article
Text
id pubmed-7357909
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Editorial office of Chinese Journal of Hematology
record_format MEDLINE/PubMed
spelling pubmed-73579092020-07-16 急性白血病患者化疗后骨髓抑制期血浆凝血因子XIII水平及其对出血事件的影响 Zhonghua Xue Ye Xue Za Zhi 论著 OBJECTIVE: To explore the relationship between plasma coagulation factor XIII (FXIII) and bleeding events. METHODS: A total of 55 cases of acute leukemia (AL) at the myelosuppression phase after chemotherapy hospitalized in our hospital from August 2017 to March 2018 were enrolled, with 35 normal controls. The concentration of plasma coagulation factor XIII (FXIII) was detected by ELISA to determine the relationship between the plasma FXIII levels in AL patients at the myelosuppression phase after chemotherapy with bleeding events. RESULTS: The level of FXIII in AL patients at the myelosuppression phase after chemotherapy was significantly lower than that in controls (P<0.001). The level of FXIII was inversely related with the bleeding severity (the Spearman correlation coefficient -0.761). Given the diagnosis cut-off point of FXIII concentration as 103.9 µg/L, the sensitivity of diagnosing bleeding in AL patients at the myelosuppression phase after chemotherapy was 0.939, and the specificity 0.909. CONCLUSION: AL patients at the myelosuppression phase after chemotherapy had low level of plasma FXIII, and patients with lower plasma FXIII associated with higher incidence and severity of bleeding. FXIII level was an independent influencing factor of bleeding in AL patients at the myelosuppression phase after chemotherapy. Editorial office of Chinese Journal of Hematology 2020-01 /pmc/articles/PMC7357909/ /pubmed/32023756 http://dx.doi.org/10.3760/cma.j.issn.0253-2727.2020.01.011 Text en 2020年版权归中华医学会所有 http://creativecommons.org/licenses/by-nc-sa/3.0/ This work is licensed under a Creative Commons Attribution 3.0 License (CC-BY-NC). The Copyright own by Publisher. Without authorization, shall not reprint, except this publication article, shall not use this publication format design. Unless otherwise stated, all articles published in this journal do not represent the views of the Chinese Medical Association or the editorial board of this journal.
spellingShingle 论著
急性白血病患者化疗后骨髓抑制期血浆凝血因子XIII水平及其对出血事件的影响
title 急性白血病患者化疗后骨髓抑制期血浆凝血因子XIII水平及其对出血事件的影响
title_full 急性白血病患者化疗后骨髓抑制期血浆凝血因子XIII水平及其对出血事件的影响
title_fullStr 急性白血病患者化疗后骨髓抑制期血浆凝血因子XIII水平及其对出血事件的影响
title_full_unstemmed 急性白血病患者化疗后骨髓抑制期血浆凝血因子XIII水平及其对出血事件的影响
title_short 急性白血病患者化疗后骨髓抑制期血浆凝血因子XIII水平及其对出血事件的影响
title_sort 急性白血病患者化疗后骨髓抑制期血浆凝血因子xiii水平及其对出血事件的影响
topic 论著
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7357909/
https://www.ncbi.nlm.nih.gov/pubmed/32023756
http://dx.doi.org/10.3760/cma.j.issn.0253-2727.2020.01.011
work_keys_str_mv AT jíxìngbáixuèbìnghuànzhěhuàliáohòugǔsuǐyìzhìqīxuèjiāngníngxuèyīnzixiiishuǐpíngjíqíduìchūxuèshìjiàndeyǐngxiǎng
AT jíxìngbáixuèbìnghuànzhěhuàliáohòugǔsuǐyìzhìqīxuèjiāngníngxuèyīnzixiiishuǐpíngjíqíduìchūxuèshìjiàndeyǐngxiǎng
AT jíxìngbáixuèbìnghuànzhěhuàliáohòugǔsuǐyìzhìqīxuèjiāngníngxuèyīnzixiiishuǐpíngjíqíduìchūxuèshìjiàndeyǐngxiǎng
AT jíxìngbáixuèbìnghuànzhěhuàliáohòugǔsuǐyìzhìqīxuèjiāngníngxuèyīnzixiiishuǐpíngjíqíduìchūxuèshìjiàndeyǐngxiǎng