Quantitative Visualization of Lanthanum Accumulation in Lanthanum Carbonate-Administered Human Stomach Tissues Using Mass Spectrometry Imaging

Platinum, a transition metal that is widely used in anti-cancer agents, also results in the development of nephropathy due to severe adverse reactions caused by platinum-induced nephrotoxicity. Reports on imaging with metals other than platinum remain are limited, even in preclinical studies. Furthe...

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Autores principales: Shimma, Shuichi, Makino, Yoshiki, Kojima, Kazuto, Hirata, Takafumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Mass Spectrometry Society of Japan 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7358108/
https://www.ncbi.nlm.nih.gov/pubmed/32754422
http://dx.doi.org/10.5702/massspectrometry.A0086
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author Shimma, Shuichi
Makino, Yoshiki
Kojima, Kazuto
Hirata, Takafumi
author_facet Shimma, Shuichi
Makino, Yoshiki
Kojima, Kazuto
Hirata, Takafumi
author_sort Shimma, Shuichi
collection PubMed
description Platinum, a transition metal that is widely used in anti-cancer agents, also results in the development of nephropathy due to severe adverse reactions caused by platinum-induced nephrotoxicity. Reports on imaging with metals other than platinum remain are limited, even in preclinical studies. Furthermore, most of these are case reports, and the relationship between the distribution of the metal and clinical observations in human samples is not well understood. Here we report on visualizing lanthanum ((139)La), a component of Fosrenol, which is usually used for the treatment of hyperphosphatemia. Gastric inflammation, also known as hemorrhagic gastritis, is the main adverse event caused by Fosrenol. To conduct this study, (139)La was visualized in gastric biopsy samples obtained from a patient using quantitative laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS). We also compared the distribution of (139)La in tissue and histochemical results. The areas where (139)La accumulated corresponded to the macrophage-positive areas observed in immunohistochemistry studies using an anti-CD68 antibody. In contrast, we observed a debris-like crystal morphology in hematoxylin and eosin staining tissues. The debris was also associated with (139)La accumulation. The abnormal accumulation of (139)La crystals caused the observed inflammation. This phenomenon was previously characterized, but this is the first report in which (139)La distribution and histochemical results are compared using LA-ICP-MS.
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spelling pubmed-73581082020-08-03 Quantitative Visualization of Lanthanum Accumulation in Lanthanum Carbonate-Administered Human Stomach Tissues Using Mass Spectrometry Imaging Shimma, Shuichi Makino, Yoshiki Kojima, Kazuto Hirata, Takafumi Mass Spectrom (Tokyo) Original Article Platinum, a transition metal that is widely used in anti-cancer agents, also results in the development of nephropathy due to severe adverse reactions caused by platinum-induced nephrotoxicity. Reports on imaging with metals other than platinum remain are limited, even in preclinical studies. Furthermore, most of these are case reports, and the relationship between the distribution of the metal and clinical observations in human samples is not well understood. Here we report on visualizing lanthanum ((139)La), a component of Fosrenol, which is usually used for the treatment of hyperphosphatemia. Gastric inflammation, also known as hemorrhagic gastritis, is the main adverse event caused by Fosrenol. To conduct this study, (139)La was visualized in gastric biopsy samples obtained from a patient using quantitative laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS). We also compared the distribution of (139)La in tissue and histochemical results. The areas where (139)La accumulated corresponded to the macrophage-positive areas observed in immunohistochemistry studies using an anti-CD68 antibody. In contrast, we observed a debris-like crystal morphology in hematoxylin and eosin staining tissues. The debris was also associated with (139)La accumulation. The abnormal accumulation of (139)La crystals caused the observed inflammation. This phenomenon was previously characterized, but this is the first report in which (139)La distribution and histochemical results are compared using LA-ICP-MS. The Mass Spectrometry Society of Japan 2020 2020-07-13 /pmc/articles/PMC7358108/ /pubmed/32754422 http://dx.doi.org/10.5702/massspectrometry.A0086 Text en Copyright © 2020 Shuichi Shimma, Yoshiki Makino, Kazuto Kojima, and Takafumi Hirata. http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the terms of Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Article
Shimma, Shuichi
Makino, Yoshiki
Kojima, Kazuto
Hirata, Takafumi
Quantitative Visualization of Lanthanum Accumulation in Lanthanum Carbonate-Administered Human Stomach Tissues Using Mass Spectrometry Imaging
title Quantitative Visualization of Lanthanum Accumulation in Lanthanum Carbonate-Administered Human Stomach Tissues Using Mass Spectrometry Imaging
title_full Quantitative Visualization of Lanthanum Accumulation in Lanthanum Carbonate-Administered Human Stomach Tissues Using Mass Spectrometry Imaging
title_fullStr Quantitative Visualization of Lanthanum Accumulation in Lanthanum Carbonate-Administered Human Stomach Tissues Using Mass Spectrometry Imaging
title_full_unstemmed Quantitative Visualization of Lanthanum Accumulation in Lanthanum Carbonate-Administered Human Stomach Tissues Using Mass Spectrometry Imaging
title_short Quantitative Visualization of Lanthanum Accumulation in Lanthanum Carbonate-Administered Human Stomach Tissues Using Mass Spectrometry Imaging
title_sort quantitative visualization of lanthanum accumulation in lanthanum carbonate-administered human stomach tissues using mass spectrometry imaging
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7358108/
https://www.ncbi.nlm.nih.gov/pubmed/32754422
http://dx.doi.org/10.5702/massspectrometry.A0086
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