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Longitudinal TSPO expression in tau transgenic P301S mice predicts increased tau accumulation and deteriorated spatial learning

BACKGROUND: P301S tau transgenic mice show age-dependent accumulation of neurofibrillary tangles in the brainstem, hippocampus, and neocortex, leading to neuronal loss and cognitive deterioration. However, there is hitherto only sparse documentation of the role of neuroinflammation in tau mouse mode...

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Detalles Bibliográficos
Autores principales:	Eckenweber, Florian, Medina-Luque, Jose, Blume, Tanja, Sacher, Christian, Biechele, Gloria, Wind, Karin, Deussing, Maximilian, Briel, Nils, Lindner, Simon, Boening, Guido, von Ungern-Sternberg, Barbara, Unterrainer, Marcus, Albert, Nathalie L., Zwergal, Andreas, Levin, Johannes, Bartenstein, Peter, Cumming, Paul, Rominger, Axel, Höglinger, Günter U., Herms, Jochen, Brendel, Matthias
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7358201/ https://www.ncbi.nlm.nih.gov/pubmed/32660586 http://dx.doi.org/10.1186/s12974-020-01883-5

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