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Functional and cognitive outcomes after COVID-19 delirium

PURPOSE: To ascertain delirium prevalence and outcomes in COVID-19. METHODS: We conducted a point-prevalence study in a cohort of COVID-19 inpatients at University College Hospital. Delirium was defined by DSM-IV criteria. The primary outcome was all-cause mortality at 4 weeks; secondary outcomes we...

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Autores principales: Mcloughlin, Benjamin C., Miles, Amy, Webb, Thomas E., Knopp, Paul, Eyres, Clodagh, Fabbri, Ambra, Humphries, Fiona, Davis, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7358317/
https://www.ncbi.nlm.nih.gov/pubmed/32666303
http://dx.doi.org/10.1007/s41999-020-00353-8
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author Mcloughlin, Benjamin C.
Miles, Amy
Webb, Thomas E.
Knopp, Paul
Eyres, Clodagh
Fabbri, Ambra
Humphries, Fiona
Davis, Daniel
author_facet Mcloughlin, Benjamin C.
Miles, Amy
Webb, Thomas E.
Knopp, Paul
Eyres, Clodagh
Fabbri, Ambra
Humphries, Fiona
Davis, Daniel
author_sort Mcloughlin, Benjamin C.
collection PubMed
description PURPOSE: To ascertain delirium prevalence and outcomes in COVID-19. METHODS: We conducted a point-prevalence study in a cohort of COVID-19 inpatients at University College Hospital. Delirium was defined by DSM-IV criteria. The primary outcome was all-cause mortality at 4 weeks; secondary outcomes were physical and cognitive function. RESULTS: In 71 patients (mean age 61, 75% men), 31 (42%) had delirium, of which only 12 (39%) had been recognised by the clinical team. At 4 weeks, 20 (28%) had died, 26 (36%) were interviewed by telephone and 21 (30%) remained as inpatients. Physical function was substantially worse in people after delirium − 50 out of 166 points (95% CI − 83 to − 17, p = 0.01). Mean cognitive scores at follow-up were similar and delirium was not associated with mortality in this sample. CONCLUSIONS: Our findings indicate that delirium is common, yet under-recognised. Delirium is associated with functional impairments in the medium term. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s41999-020-00353-8) contains supplementary material, which is available to authorized users.
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spelling pubmed-73583172020-07-14 Functional and cognitive outcomes after COVID-19 delirium Mcloughlin, Benjamin C. Miles, Amy Webb, Thomas E. Knopp, Paul Eyres, Clodagh Fabbri, Ambra Humphries, Fiona Davis, Daniel Eur Geriatr Med Brief Report PURPOSE: To ascertain delirium prevalence and outcomes in COVID-19. METHODS: We conducted a point-prevalence study in a cohort of COVID-19 inpatients at University College Hospital. Delirium was defined by DSM-IV criteria. The primary outcome was all-cause mortality at 4 weeks; secondary outcomes were physical and cognitive function. RESULTS: In 71 patients (mean age 61, 75% men), 31 (42%) had delirium, of which only 12 (39%) had been recognised by the clinical team. At 4 weeks, 20 (28%) had died, 26 (36%) were interviewed by telephone and 21 (30%) remained as inpatients. Physical function was substantially worse in people after delirium − 50 out of 166 points (95% CI − 83 to − 17, p = 0.01). Mean cognitive scores at follow-up were similar and delirium was not associated with mortality in this sample. CONCLUSIONS: Our findings indicate that delirium is common, yet under-recognised. Delirium is associated with functional impairments in the medium term. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s41999-020-00353-8) contains supplementary material, which is available to authorized users. Springer International Publishing 2020-07-14 2020 /pmc/articles/PMC7358317/ /pubmed/32666303 http://dx.doi.org/10.1007/s41999-020-00353-8 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Brief Report
Mcloughlin, Benjamin C.
Miles, Amy
Webb, Thomas E.
Knopp, Paul
Eyres, Clodagh
Fabbri, Ambra
Humphries, Fiona
Davis, Daniel
Functional and cognitive outcomes after COVID-19 delirium
title Functional and cognitive outcomes after COVID-19 delirium
title_full Functional and cognitive outcomes after COVID-19 delirium
title_fullStr Functional and cognitive outcomes after COVID-19 delirium
title_full_unstemmed Functional and cognitive outcomes after COVID-19 delirium
title_short Functional and cognitive outcomes after COVID-19 delirium
title_sort functional and cognitive outcomes after covid-19 delirium
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7358317/
https://www.ncbi.nlm.nih.gov/pubmed/32666303
http://dx.doi.org/10.1007/s41999-020-00353-8
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