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Functional and cognitive outcomes after COVID-19 delirium
PURPOSE: To ascertain delirium prevalence and outcomes in COVID-19. METHODS: We conducted a point-prevalence study in a cohort of COVID-19 inpatients at University College Hospital. Delirium was defined by DSM-IV criteria. The primary outcome was all-cause mortality at 4 weeks; secondary outcomes we...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7358317/ https://www.ncbi.nlm.nih.gov/pubmed/32666303 http://dx.doi.org/10.1007/s41999-020-00353-8 |
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author | Mcloughlin, Benjamin C. Miles, Amy Webb, Thomas E. Knopp, Paul Eyres, Clodagh Fabbri, Ambra Humphries, Fiona Davis, Daniel |
author_facet | Mcloughlin, Benjamin C. Miles, Amy Webb, Thomas E. Knopp, Paul Eyres, Clodagh Fabbri, Ambra Humphries, Fiona Davis, Daniel |
author_sort | Mcloughlin, Benjamin C. |
collection | PubMed |
description | PURPOSE: To ascertain delirium prevalence and outcomes in COVID-19. METHODS: We conducted a point-prevalence study in a cohort of COVID-19 inpatients at University College Hospital. Delirium was defined by DSM-IV criteria. The primary outcome was all-cause mortality at 4 weeks; secondary outcomes were physical and cognitive function. RESULTS: In 71 patients (mean age 61, 75% men), 31 (42%) had delirium, of which only 12 (39%) had been recognised by the clinical team. At 4 weeks, 20 (28%) had died, 26 (36%) were interviewed by telephone and 21 (30%) remained as inpatients. Physical function was substantially worse in people after delirium − 50 out of 166 points (95% CI − 83 to − 17, p = 0.01). Mean cognitive scores at follow-up were similar and delirium was not associated with mortality in this sample. CONCLUSIONS: Our findings indicate that delirium is common, yet under-recognised. Delirium is associated with functional impairments in the medium term. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s41999-020-00353-8) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-7358317 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-73583172020-07-14 Functional and cognitive outcomes after COVID-19 delirium Mcloughlin, Benjamin C. Miles, Amy Webb, Thomas E. Knopp, Paul Eyres, Clodagh Fabbri, Ambra Humphries, Fiona Davis, Daniel Eur Geriatr Med Brief Report PURPOSE: To ascertain delirium prevalence and outcomes in COVID-19. METHODS: We conducted a point-prevalence study in a cohort of COVID-19 inpatients at University College Hospital. Delirium was defined by DSM-IV criteria. The primary outcome was all-cause mortality at 4 weeks; secondary outcomes were physical and cognitive function. RESULTS: In 71 patients (mean age 61, 75% men), 31 (42%) had delirium, of which only 12 (39%) had been recognised by the clinical team. At 4 weeks, 20 (28%) had died, 26 (36%) were interviewed by telephone and 21 (30%) remained as inpatients. Physical function was substantially worse in people after delirium − 50 out of 166 points (95% CI − 83 to − 17, p = 0.01). Mean cognitive scores at follow-up were similar and delirium was not associated with mortality in this sample. CONCLUSIONS: Our findings indicate that delirium is common, yet under-recognised. Delirium is associated with functional impairments in the medium term. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s41999-020-00353-8) contains supplementary material, which is available to authorized users. Springer International Publishing 2020-07-14 2020 /pmc/articles/PMC7358317/ /pubmed/32666303 http://dx.doi.org/10.1007/s41999-020-00353-8 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Brief Report Mcloughlin, Benjamin C. Miles, Amy Webb, Thomas E. Knopp, Paul Eyres, Clodagh Fabbri, Ambra Humphries, Fiona Davis, Daniel Functional and cognitive outcomes after COVID-19 delirium |
title | Functional and cognitive outcomes after COVID-19 delirium |
title_full | Functional and cognitive outcomes after COVID-19 delirium |
title_fullStr | Functional and cognitive outcomes after COVID-19 delirium |
title_full_unstemmed | Functional and cognitive outcomes after COVID-19 delirium |
title_short | Functional and cognitive outcomes after COVID-19 delirium |
title_sort | functional and cognitive outcomes after covid-19 delirium |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7358317/ https://www.ncbi.nlm.nih.gov/pubmed/32666303 http://dx.doi.org/10.1007/s41999-020-00353-8 |
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