Specific protein-protein interactions limit the cutaneous iontophoretic transport of interferon beta-1B and a poly-ARG interferon beta-1B analogue

The first objective was to investigate the transdermal iontophoresis of interferon beta 1b (IFN); the second was to determine whether the addition of 10 Arg residues at the N-terminus, creating a highly charged poly-Arg analogue (Arg(10)-IFN), increased delivery. Cumulative permeation of IFN and Arg...

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Detalles Bibliográficos
Autores principales: Dubey, S., Perozzo, R., Scapozza, L., Kalia, Y.N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7358383/
https://www.ncbi.nlm.nih.gov/pubmed/32685921
http://dx.doi.org/10.1016/j.ijpx.2020.100051

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7358383/
https://www.ncbi.nlm.nih.gov/pubmed/32685921
http://dx.doi.org/10.1016/j.ijpx.2020.100051

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