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Growth Factors in Regeneration and Regenerative Medicine: “the Cure and the Cause”
The potential rapid advance of regenerative medicine was obstructed by findings that stimulation of human body regeneration is a much tougher mission than expected after the first cultures of stem and progenitor cells were established. In this mini review, we focus on the ambiguous role of growth fa...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7358447/ https://www.ncbi.nlm.nih.gov/pubmed/32733378 http://dx.doi.org/10.3389/fendo.2020.00384 |
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author | Kulebyakin, Konstantin Yu. Nimiritsky, Peter P. Makarevich, Pavel I. |
author_facet | Kulebyakin, Konstantin Yu. Nimiritsky, Peter P. Makarevich, Pavel I. |
author_sort | Kulebyakin, Konstantin Yu. |
collection | PubMed |
description | The potential rapid advance of regenerative medicine was obstructed by findings that stimulation of human body regeneration is a much tougher mission than expected after the first cultures of stem and progenitor cells were established. In this mini review, we focus on the ambiguous role of growth factors in regeneration, discuss their evolutionary importance, and highlight them as the “cure and the cause” for successful or failed attempts to drive human body regeneration. We draw the reader's attention to evolutionary changes that occurred in growth factors and their receptor tyrosine kinases (RTKs) and how they established and shaped response to injury in metazoans. Discussing the well-known pleiotropy of growth factors, we propose an evolutionary rationale for their functioning in this specific way and focus on growth factors and RTKs as an amazing system that defines the multicellular nature of animals and highlight their participation in regeneration. We pinpoint potential bottlenecks in their application for human tissue regeneration and show their role in fibrosis/regeneration balance. This communication invites the reader to re-evaluate the functions of growth factors as keepers of natively existing communications between elements of tissue, which makes them a fundamental component of a successful regenerative strategy. Finally, we draw attention to the epigenetic landscape that may facilitate or block regeneration and give a brief insight into how it may define the outcome of injury. |
format | Online Article Text |
id | pubmed-7358447 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-73584472020-07-29 Growth Factors in Regeneration and Regenerative Medicine: “the Cure and the Cause” Kulebyakin, Konstantin Yu. Nimiritsky, Peter P. Makarevich, Pavel I. Front Endocrinol (Lausanne) Endocrinology The potential rapid advance of regenerative medicine was obstructed by findings that stimulation of human body regeneration is a much tougher mission than expected after the first cultures of stem and progenitor cells were established. In this mini review, we focus on the ambiguous role of growth factors in regeneration, discuss their evolutionary importance, and highlight them as the “cure and the cause” for successful or failed attempts to drive human body regeneration. We draw the reader's attention to evolutionary changes that occurred in growth factors and their receptor tyrosine kinases (RTKs) and how they established and shaped response to injury in metazoans. Discussing the well-known pleiotropy of growth factors, we propose an evolutionary rationale for their functioning in this specific way and focus on growth factors and RTKs as an amazing system that defines the multicellular nature of animals and highlight their participation in regeneration. We pinpoint potential bottlenecks in their application for human tissue regeneration and show their role in fibrosis/regeneration balance. This communication invites the reader to re-evaluate the functions of growth factors as keepers of natively existing communications between elements of tissue, which makes them a fundamental component of a successful regenerative strategy. Finally, we draw attention to the epigenetic landscape that may facilitate or block regeneration and give a brief insight into how it may define the outcome of injury. Frontiers Media S.A. 2020-07-07 /pmc/articles/PMC7358447/ /pubmed/32733378 http://dx.doi.org/10.3389/fendo.2020.00384 Text en Copyright © 2020 Kulebyakin, Nimiritsky and Makarevich. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Kulebyakin, Konstantin Yu. Nimiritsky, Peter P. Makarevich, Pavel I. Growth Factors in Regeneration and Regenerative Medicine: “the Cure and the Cause” |
title | Growth Factors in Regeneration and Regenerative Medicine: “the Cure and the Cause” |
title_full | Growth Factors in Regeneration and Regenerative Medicine: “the Cure and the Cause” |
title_fullStr | Growth Factors in Regeneration and Regenerative Medicine: “the Cure and the Cause” |
title_full_unstemmed | Growth Factors in Regeneration and Regenerative Medicine: “the Cure and the Cause” |
title_short | Growth Factors in Regeneration and Regenerative Medicine: “the Cure and the Cause” |
title_sort | growth factors in regeneration and regenerative medicine: “the cure and the cause” |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7358447/ https://www.ncbi.nlm.nih.gov/pubmed/32733378 http://dx.doi.org/10.3389/fendo.2020.00384 |
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