Caffeic Acid Phenethyl Ester Ameliorates Calcification by Inhibiting Activation of the AKT/NF-κB/NLRP3 Inflammasome Pathway in Human Aortic Valve Interstitial Cells

Calcific aortic valve disease (CAVD) occurs via a pathophysiological process that includes inflammation-induced osteoblastic differentiation of aortic valvular interstitial cells (AVICs). Here, we investigated the role of the anti-inflammatory compound caffeic acid phenethyl ester (CAPE) in inhibiti...

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Detalles Bibliográficos
Autores principales: Liu, Ming, Li, Fei, Huang, Yuming, Zhou, Tingwen, Chen, Si, Li, Geng, Shi, Jiawei, Dong, Nianguo, Xu, Kang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7358518/
https://www.ncbi.nlm.nih.gov/pubmed/32733235
http://dx.doi.org/10.3389/fphar.2020.00826

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