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Mechanisms of RNA N(6)-Methyladenosine in Hepatocellular Carcinoma: From the Perspectives of Etiology

N6-Methyladenosine (m(6)A) is the most common RNA internal modification in eukaryotic cells. Its regulatory effects at the post-transcriptional level on both messenger RNAs (mRNAs) and noncoding RNAs have been widely studied; these include alternative splicing, stability, translation efficiency, nuc...

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Autores principales: Lu, Jiahua, Qian, Junjie, Yin, Shengyong, Zhou, Lin, Zheng, Shusen, Zhang, Wu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7358598/
https://www.ncbi.nlm.nih.gov/pubmed/32733807
http://dx.doi.org/10.3389/fonc.2020.01105
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author Lu, Jiahua
Qian, Junjie
Yin, Shengyong
Zhou, Lin
Zheng, Shusen
Zhang, Wu
author_facet Lu, Jiahua
Qian, Junjie
Yin, Shengyong
Zhou, Lin
Zheng, Shusen
Zhang, Wu
author_sort Lu, Jiahua
collection PubMed
description N6-Methyladenosine (m(6)A) is the most common RNA internal modification in eukaryotic cells. Its regulatory effects at the post-transcriptional level on both messenger RNAs (mRNAs) and noncoding RNAs have been widely studied; these include alternative splicing, stability, translation efficiency, nucleus export, and degradation. m(6)A modification is implicated in a series of physiological and pathological activities, such as embryonic stem cell differentiation, immunoregulation, adipogenesis, and cancer development. Recently, the significance of m(6)A methylation has been identified in both viral hepatitis and non-alcohol fatty liver disease (NAFLD), which are major risk factors in the development of hepatocellular carcinoma (HCC). Given the high incidence and mortality rate of HCC worldwide, it is of great importance to elucidate the mechanisms underlying HCC initiation and progression. m(6)A as an emerging research focus has great potential to facilitate the understanding of HCC, particularly from an etiological perspective. Thus, in this review, we summarize recent progress in understanding m(6)A modification related to viral hepatitis, NAFLD, and HCC, including their mechanisms and clinical applications.
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spelling pubmed-73585982020-07-29 Mechanisms of RNA N(6)-Methyladenosine in Hepatocellular Carcinoma: From the Perspectives of Etiology Lu, Jiahua Qian, Junjie Yin, Shengyong Zhou, Lin Zheng, Shusen Zhang, Wu Front Oncol Oncology N6-Methyladenosine (m(6)A) is the most common RNA internal modification in eukaryotic cells. Its regulatory effects at the post-transcriptional level on both messenger RNAs (mRNAs) and noncoding RNAs have been widely studied; these include alternative splicing, stability, translation efficiency, nucleus export, and degradation. m(6)A modification is implicated in a series of physiological and pathological activities, such as embryonic stem cell differentiation, immunoregulation, adipogenesis, and cancer development. Recently, the significance of m(6)A methylation has been identified in both viral hepatitis and non-alcohol fatty liver disease (NAFLD), which are major risk factors in the development of hepatocellular carcinoma (HCC). Given the high incidence and mortality rate of HCC worldwide, it is of great importance to elucidate the mechanisms underlying HCC initiation and progression. m(6)A as an emerging research focus has great potential to facilitate the understanding of HCC, particularly from an etiological perspective. Thus, in this review, we summarize recent progress in understanding m(6)A modification related to viral hepatitis, NAFLD, and HCC, including their mechanisms and clinical applications. Frontiers Media S.A. 2020-07-07 /pmc/articles/PMC7358598/ /pubmed/32733807 http://dx.doi.org/10.3389/fonc.2020.01105 Text en Copyright © 2020 Lu, Qian, Yin, Zhou, Zheng and Zhang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Lu, Jiahua
Qian, Junjie
Yin, Shengyong
Zhou, Lin
Zheng, Shusen
Zhang, Wu
Mechanisms of RNA N(6)-Methyladenosine in Hepatocellular Carcinoma: From the Perspectives of Etiology
title Mechanisms of RNA N(6)-Methyladenosine in Hepatocellular Carcinoma: From the Perspectives of Etiology
title_full Mechanisms of RNA N(6)-Methyladenosine in Hepatocellular Carcinoma: From the Perspectives of Etiology
title_fullStr Mechanisms of RNA N(6)-Methyladenosine in Hepatocellular Carcinoma: From the Perspectives of Etiology
title_full_unstemmed Mechanisms of RNA N(6)-Methyladenosine in Hepatocellular Carcinoma: From the Perspectives of Etiology
title_short Mechanisms of RNA N(6)-Methyladenosine in Hepatocellular Carcinoma: From the Perspectives of Etiology
title_sort mechanisms of rna n(6)-methyladenosine in hepatocellular carcinoma: from the perspectives of etiology
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7358598/
https://www.ncbi.nlm.nih.gov/pubmed/32733807
http://dx.doi.org/10.3389/fonc.2020.01105
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