Advances in the Study of Structural Modification and Biological Activities of Anoplin

Anoplin is an amphipathic, α-helical bioactive peptide from wasp venom. In recent years, pharmaceutical and organic chemists discovered that anoplin and its derivatives showed multiple pharmacological activities in antibacterial, antitumor, antifungal, and antimalarial activities. Owing to the simpl...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Ye, Huang, Rui, Jin, Jin-Mei, Zhang, Li-Jun, Zhang, Hong, Chen, Hong-Zhuan, Chen, Li-Li, Luan, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7358703/
https://www.ncbi.nlm.nih.gov/pubmed/32733845
http://dx.doi.org/10.3389/fchem.2020.00519
_version_ 1783558897427021824
author Wu, Ye
Huang, Rui
Jin, Jin-Mei
Zhang, Li-Jun
Zhang, Hong
Chen, Hong-Zhuan
Chen, Li-Li
Luan, Xin
author_facet Wu, Ye
Huang, Rui
Jin, Jin-Mei
Zhang, Li-Jun
Zhang, Hong
Chen, Hong-Zhuan
Chen, Li-Li
Luan, Xin
author_sort Wu, Ye
collection PubMed
description Anoplin is an amphipathic, α-helical bioactive peptide from wasp venom. In recent years, pharmaceutical and organic chemists discovered that anoplin and its derivatives showed multiple pharmacological activities in antibacterial, antitumor, antifungal, and antimalarial activities. Owing to the simple and unique structure and diverse biological activities, anoplin has attracted considerable research interests. This review highlights the advances in structural modification, biological activities, and the outlook of anoplin in order to provide a basis for new drug design and delivery.
format Online
Article
Text
id pubmed-7358703
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-73587032020-07-29 Advances in the Study of Structural Modification and Biological Activities of Anoplin Wu, Ye Huang, Rui Jin, Jin-Mei Zhang, Li-Jun Zhang, Hong Chen, Hong-Zhuan Chen, Li-Li Luan, Xin Front Chem Chemistry Anoplin is an amphipathic, α-helical bioactive peptide from wasp venom. In recent years, pharmaceutical and organic chemists discovered that anoplin and its derivatives showed multiple pharmacological activities in antibacterial, antitumor, antifungal, and antimalarial activities. Owing to the simple and unique structure and diverse biological activities, anoplin has attracted considerable research interests. This review highlights the advances in structural modification, biological activities, and the outlook of anoplin in order to provide a basis for new drug design and delivery. Frontiers Media S.A. 2020-07-07 /pmc/articles/PMC7358703/ /pubmed/32733845 http://dx.doi.org/10.3389/fchem.2020.00519 Text en Copyright © 2020 Wu, Huang, Jin, Zhang, Zhang, Chen, Chen and Luan. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Wu, Ye
Huang, Rui
Jin, Jin-Mei
Zhang, Li-Jun
Zhang, Hong
Chen, Hong-Zhuan
Chen, Li-Li
Luan, Xin
Advances in the Study of Structural Modification and Biological Activities of Anoplin
title Advances in the Study of Structural Modification and Biological Activities of Anoplin
title_full Advances in the Study of Structural Modification and Biological Activities of Anoplin
title_fullStr Advances in the Study of Structural Modification and Biological Activities of Anoplin
title_full_unstemmed Advances in the Study of Structural Modification and Biological Activities of Anoplin
title_short Advances in the Study of Structural Modification and Biological Activities of Anoplin
title_sort advances in the study of structural modification and biological activities of anoplin
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7358703/
https://www.ncbi.nlm.nih.gov/pubmed/32733845
http://dx.doi.org/10.3389/fchem.2020.00519
work_keys_str_mv AT wuye advancesinthestudyofstructuralmodificationandbiologicalactivitiesofanoplin
AT huangrui advancesinthestudyofstructuralmodificationandbiologicalactivitiesofanoplin
AT jinjinmei advancesinthestudyofstructuralmodificationandbiologicalactivitiesofanoplin
AT zhanglijun advancesinthestudyofstructuralmodificationandbiologicalactivitiesofanoplin
AT zhanghong advancesinthestudyofstructuralmodificationandbiologicalactivitiesofanoplin
AT chenhongzhuan advancesinthestudyofstructuralmodificationandbiologicalactivitiesofanoplin
AT chenlili advancesinthestudyofstructuralmodificationandbiologicalactivitiesofanoplin
AT luanxin advancesinthestudyofstructuralmodificationandbiologicalactivitiesofanoplin

Ejemplares similares