Recombinant protein targeting and opsonizing spike glycoprotein for enhancing SARS-CoV-2 phagocytosis

The present hypothesis suggests an innovative therapeutic strategy to cease Covid 19 infection. It is based on the inhibition of Spike glycoprotein and ACE-2 receptor interaction that provides the entry of virus in human host cells, by targeting the S protein with a recombinant molecule made of the...

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Detalles Bibliográficos
Autor principal: Khattabi, Latifa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2020
Materias:
Letter to Editors
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7358758/
https://www.ncbi.nlm.nih.gov/pubmed/32721804
http://dx.doi.org/10.1016/j.mehy.2020.110108
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author Khattabi, Latifa
author_facet Khattabi, Latifa
author_sort Khattabi, Latifa
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description The present hypothesis suggests an innovative therapeutic strategy to cease Covid 19 infection. It is based on the inhibition of Spike glycoprotein and ACE-2 receptor interaction that provides the entry of virus in human host cells, by targeting the S protein with a recombinant molecule made of the ACE-2 receptor ectodomain and an opsonin, the formed complex would enhance its phagocytosis.
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spelling pubmed-73587582020-07-14 Recombinant protein targeting and opsonizing spike glycoprotein for enhancing SARS-CoV-2 phagocytosis Khattabi, Latifa Med Hypotheses Letter to Editors The present hypothesis suggests an innovative therapeutic strategy to cease Covid 19 infection. It is based on the inhibition of Spike glycoprotein and ACE-2 receptor interaction that provides the entry of virus in human host cells, by targeting the S protein with a recombinant molecule made of the ACE-2 receptor ectodomain and an opsonin, the formed complex would enhance its phagocytosis. Elsevier Ltd. 2020-10 2020-07-14 /pmc/articles/PMC7358758/ /pubmed/32721804 http://dx.doi.org/10.1016/j.mehy.2020.110108 Text en © 2020 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Letter to Editors
Khattabi, Latifa
Recombinant protein targeting and opsonizing spike glycoprotein for enhancing SARS-CoV-2 phagocytosis
title Recombinant protein targeting and opsonizing spike glycoprotein for enhancing SARS-CoV-2 phagocytosis
title_full Recombinant protein targeting and opsonizing spike glycoprotein for enhancing SARS-CoV-2 phagocytosis
title_fullStr Recombinant protein targeting and opsonizing spike glycoprotein for enhancing SARS-CoV-2 phagocytosis
title_full_unstemmed Recombinant protein targeting and opsonizing spike glycoprotein for enhancing SARS-CoV-2 phagocytosis
title_short Recombinant protein targeting and opsonizing spike glycoprotein for enhancing SARS-CoV-2 phagocytosis
title_sort recombinant protein targeting and opsonizing spike glycoprotein for enhancing sars-cov-2 phagocytosis
topic Letter to Editors
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7358758/
https://www.ncbi.nlm.nih.gov/pubmed/32721804
http://dx.doi.org/10.1016/j.mehy.2020.110108
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